Expression of multidrug resistance markers ABCB1 (MDR-1/P-gp) and ABCC1 (MRP-1) in renal cell carcinoma.

Hdl Handle:
http://hdl.handle.net/10147/94205
Title:
Expression of multidrug resistance markers ABCB1 (MDR-1/P-gp) and ABCC1 (MRP-1) in renal cell carcinoma.
Authors:
Walsh, Naomi; Larkin, Annemarie; Kennedy, Susan; Connolly, Lisa; Ballot, Jo; Ooi, Wei; Gullo, Giuseppe; Crown, John; Clynes, Martin; O'Driscoll, Lorraine
Affiliation:
National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland. naomi.walsh@dcu.ie
Citation:
Expression of multidrug resistance markers ABCB1 (MDR-1/P-gp) and ABCC1 (MRP-1) in renal cell carcinoma. 2009, 9:6 BMC Urol
Journal:
BMC urology
Issue Date:
2009
URI:
http://hdl.handle.net/10147/94205
DOI:
10.1186/1471-2490-9-6
PubMed ID:
19552816
Abstract:
BACKGROUND: Renal cell carcinoma patients respond poorly to conventional chemotherapy, this unresponsiveness may be attributable to multidrug resistance (MDR). The mechanisms of MDR in renal cancer are not fully understood and the specific contribution of ABC transporter proteins which have been implicated in the chemoresistance of various cancers has not been fully defined in this disease. METHODS: In this retrospective study the expression of two of these transporter efflux pumps, namely MDR-1 P-gp (ABCB1) and MRP-1 (ABCC1) were studied by immunohistochemistry in archival material from 95 renal cell carcinoma patients. RESULTS: In the first study investigating MDR-1 P-gp and MRP-1 protein expression patterns in renal cell carcinoma patients, high levels of expression of both efflux pumps are observed with 100% of tumours studied showing MDR-1 P-gp and MRP-1 positivity. CONCLUSION: Although these findings do not prove a causal role, the high frequency of tumours expressing these efflux pumps suggests that they may be important contributors to the chemoresistance of this tumour type.
Language:
en
MeSH:
Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Renal Cell; Female; Gene Expression Regulation, Neoplastic; Humans; Kidney Neoplasms; Male; Middle Aged; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; P-Glycoprotein; Tumor Cells, Cultured; Tumor Markers, Biological
ISSN:
1471-2490

Full metadata record

DC FieldValue Language
dc.contributor.authorWalsh, Naomien
dc.contributor.authorLarkin, Annemarieen
dc.contributor.authorKennedy, Susanen
dc.contributor.authorConnolly, Lisaen
dc.contributor.authorBallot, Joen
dc.contributor.authorOoi, Weien
dc.contributor.authorGullo, Giuseppeen
dc.contributor.authorCrown, Johnen
dc.contributor.authorClynes, Martinen
dc.contributor.authorO'Driscoll, Lorraineen
dc.date.accessioned2010-03-12T15:43:02Z-
dc.date.available2010-03-12T15:43:02Z-
dc.date.issued2009-
dc.identifier.citationExpression of multidrug resistance markers ABCB1 (MDR-1/P-gp) and ABCC1 (MRP-1) in renal cell carcinoma. 2009, 9:6 BMC Urolen
dc.identifier.issn1471-2490-
dc.identifier.pmid19552816-
dc.identifier.doi10.1186/1471-2490-9-6-
dc.identifier.urihttp://hdl.handle.net/10147/94205-
dc.description.abstractBACKGROUND: Renal cell carcinoma patients respond poorly to conventional chemotherapy, this unresponsiveness may be attributable to multidrug resistance (MDR). The mechanisms of MDR in renal cancer are not fully understood and the specific contribution of ABC transporter proteins which have been implicated in the chemoresistance of various cancers has not been fully defined in this disease. METHODS: In this retrospective study the expression of two of these transporter efflux pumps, namely MDR-1 P-gp (ABCB1) and MRP-1 (ABCC1) were studied by immunohistochemistry in archival material from 95 renal cell carcinoma patients. RESULTS: In the first study investigating MDR-1 P-gp and MRP-1 protein expression patterns in renal cell carcinoma patients, high levels of expression of both efflux pumps are observed with 100% of tumours studied showing MDR-1 P-gp and MRP-1 positivity. CONCLUSION: Although these findings do not prove a causal role, the high frequency of tumours expressing these efflux pumps suggests that they may be important contributors to the chemoresistance of this tumour type.-
dc.language.isoenen
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshAntineoplastic Agents-
dc.subject.meshCarcinoma, Renal Cell-
dc.subject.meshFemale-
dc.subject.meshGene Expression Regulation, Neoplastic-
dc.subject.meshHumans-
dc.subject.meshKidney Neoplasms-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshMultidrug Resistance-Associated Proteins-
dc.subject.meshNeoplasm Proteins-
dc.subject.meshP-Glycoprotein-
dc.subject.meshTumor Cells, Cultured-
dc.subject.meshTumor Markers, Biological-
dc.titleExpression of multidrug resistance markers ABCB1 (MDR-1/P-gp) and ABCC1 (MRP-1) in renal cell carcinoma.en
dc.contributor.departmentNational Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland. naomi.walsh@dcu.ieen
dc.identifier.journalBMC urologyen

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