Sustained virologic response following HCV eradication in two brothers with X-linked agammaglobulinaemia.

Hdl Handle:
http://hdl.handle.net/10147/94023
Title:
Sustained virologic response following HCV eradication in two brothers with X-linked agammaglobulinaemia.
Authors:
Houlihan, Diarmaid D; Storan, Eoin R; Lee, John M
Affiliation:
Department of Gastroenterology, University College Hospital Galway, Newcastle Road, Galway, Ireland. diarmaidhoulihan@hotmail.com
Citation:
Sustained virologic response following HCV eradication in two brothers with X-linked agammaglobulinaemia. 2009, 15 (31):3944-6 World J. Gastroenterol.
Journal:
World journal of gastroenterology : WJG
Issue Date:
21-Aug-2009
URI:
http://hdl.handle.net/10147/94023
PubMed ID:
19701978
Abstract:
X-linked agammaglobulinaemia (XLA) is a humoral immunodeficiency syndrome characterized from childhood by the absence of circulating B lymphocytes, absent or reduced levels of serum immunoglobulin and recurrent bacterial infections. For many affected patients, regular treatment with immunoglobulin is life saving. Hepatitis C viral (HCV) infection acquired through contaminated blood products is widely described in this patient cohort. The natural history of HCV infection in patients with XLA tends to follow a more rapid and aggressive course compared to immunocompetent individuals. Furthermore, standard anti-viral therapy appears to be less efficacious in this patient cohort. Here we report the cases of two brothers with XLA who contracted HCV through contaminated blood products. They were treated with a six month course of Interferon alpha-2b and Ribavirin. We report a sustained virologic response five years after completing treatment.
Language:
en
MeSH:
Adult; Agammaglobulinemia; Antiviral Agents; Comorbidity; Drug Contamination; Genetic Diseases, X-Linked; Hepatitis C; Humans; Interferon Alfa-2b; Male; Recurrence; Ribavirin; Siblings
ISSN:
1007-9327

Full metadata record

DC FieldValue Language
dc.contributor.authorHoulihan, Diarmaid Den
dc.contributor.authorStoran, Eoin Ren
dc.contributor.authorLee, John Men
dc.date.accessioned2010-03-10T10:10:25Z-
dc.date.available2010-03-10T10:10:25Z-
dc.date.issued2009-08-21-
dc.identifier.citationSustained virologic response following HCV eradication in two brothers with X-linked agammaglobulinaemia. 2009, 15 (31):3944-6 World J. Gastroenterol.en
dc.identifier.issn1007-9327-
dc.identifier.pmid19701978-
dc.identifier.urihttp://hdl.handle.net/10147/94023-
dc.description.abstractX-linked agammaglobulinaemia (XLA) is a humoral immunodeficiency syndrome characterized from childhood by the absence of circulating B lymphocytes, absent or reduced levels of serum immunoglobulin and recurrent bacterial infections. For many affected patients, regular treatment with immunoglobulin is life saving. Hepatitis C viral (HCV) infection acquired through contaminated blood products is widely described in this patient cohort. The natural history of HCV infection in patients with XLA tends to follow a more rapid and aggressive course compared to immunocompetent individuals. Furthermore, standard anti-viral therapy appears to be less efficacious in this patient cohort. Here we report the cases of two brothers with XLA who contracted HCV through contaminated blood products. They were treated with a six month course of Interferon alpha-2b and Ribavirin. We report a sustained virologic response five years after completing treatment.-
dc.language.isoenen
dc.subject.meshAdult-
dc.subject.meshAgammaglobulinemia-
dc.subject.meshAntiviral Agents-
dc.subject.meshComorbidity-
dc.subject.meshDrug Contamination-
dc.subject.meshGenetic Diseases, X-Linked-
dc.subject.meshHepatitis C-
dc.subject.meshHumans-
dc.subject.meshInterferon Alfa-2b-
dc.subject.meshMale-
dc.subject.meshRecurrence-
dc.subject.meshRibavirin-
dc.subject.meshSiblings-
dc.titleSustained virologic response following HCV eradication in two brothers with X-linked agammaglobulinaemia.en
dc.contributor.departmentDepartment of Gastroenterology, University College Hospital Galway, Newcastle Road, Galway, Ireland. diarmaidhoulihan@hotmail.comen
dc.identifier.journalWorld journal of gastroenterology : WJGen

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