The management of acute parathyroid crisis secondary to parathyroid carcinoma: a case report.

Hdl Handle:
http://hdl.handle.net/10147/93873
Title:
The management of acute parathyroid crisis secondary to parathyroid carcinoma: a case report.
Authors:
Rock, Kathy; Fattah, Nariman; O'Malley, Diarmuid; McDermott, Enda
Affiliation:
Surgical Professorial Unit, Saint Vincent's University Hospital, Dublin 4, Ireland. kathyrock2@hotmail.com.
Citation:
The management of acute parathyroid crisis secondary to parathyroid carcinoma: a case report. 2010, 4 (1):28 J Med Case Reports
Journal:
Journal of medical case reports
Issue Date:
2010
URI:
http://hdl.handle.net/10147/93873
DOI:
10.1186/1752-1947-4-28
PubMed ID:
20181049
Abstract:
ABSTRACT: INTRODUCTION: Hypercalcaemic hyperparathyroid crisis is a rare but life-threatening complication of primary hyperparathyroidism. Parathyroid carcinoma is a rare malignancy with an incidence of 0.5% to 4% of all reported cases of primary hyperparathyroidism. CASE PRESENTATION: We report the case of a 60-year-old Caucasian man with hypercalcaemic hyperparathyroid crisis associated with parathyroid carcinoma. He presented with a classic hypercalcaemic syndrome and his serum calcium and parathyroid hormone levels were at 4.65 mmol/L and 1743 ng/L, respectively. He initially presented with a two-week history of weakness and lethargy and a one-week history of vomiting, polyuria and polydipsia. An emergency left thyroid lobectomy and left lower parathyroidectomy were performed. There was a prompt decrease in his parathyroid hormone level immediately after surgery. Histology revealed that our patient had a 4-cm parathyroid carcinoma. CONCLUSION: In patients with parathyroid carcinoma, the optimal surgical treatment is en bloc resection with ipsilateral thyroid lobectomy and removal of any enlarged or abnormal lymph nodes. Surgery is the only curative treatment. In our patient, prompt surgical intervention proved successful. At six months the patient is well with no evidence of disease recurrence. This case highlights the importance of considering a hyperparathyroid storm in the context of a parathyroid carcinoma. Parathyroid carcinoma is a rare entity and our knowledge is mainly derived from case reports and retrospective studies. This case report increases awareness of this serious and life-threatening complication. This report also illustrates how prompt and appropriate management provides the best outcome for the patient.
Language:
en
ISSN:
1752-1947

Full metadata record

DC FieldValue Language
dc.contributor.authorRock, Kathyen
dc.contributor.authorFattah, Narimanen
dc.contributor.authorO'Malley, Diarmuiden
dc.contributor.authorMcDermott, Endaen
dc.date.accessioned2010-03-08T13:15:23Z-
dc.date.available2010-03-08T13:15:23Z-
dc.date.issued2010-
dc.identifier.citationThe management of acute parathyroid crisis secondary to parathyroid carcinoma: a case report. 2010, 4 (1):28 J Med Case Reportsen
dc.identifier.issn1752-1947-
dc.identifier.pmid20181049-
dc.identifier.doi10.1186/1752-1947-4-28-
dc.identifier.urihttp://hdl.handle.net/10147/93873-
dc.description.abstractABSTRACT: INTRODUCTION: Hypercalcaemic hyperparathyroid crisis is a rare but life-threatening complication of primary hyperparathyroidism. Parathyroid carcinoma is a rare malignancy with an incidence of 0.5% to 4% of all reported cases of primary hyperparathyroidism. CASE PRESENTATION: We report the case of a 60-year-old Caucasian man with hypercalcaemic hyperparathyroid crisis associated with parathyroid carcinoma. He presented with a classic hypercalcaemic syndrome and his serum calcium and parathyroid hormone levels were at 4.65 mmol/L and 1743 ng/L, respectively. He initially presented with a two-week history of weakness and lethargy and a one-week history of vomiting, polyuria and polydipsia. An emergency left thyroid lobectomy and left lower parathyroidectomy were performed. There was a prompt decrease in his parathyroid hormone level immediately after surgery. Histology revealed that our patient had a 4-cm parathyroid carcinoma. CONCLUSION: In patients with parathyroid carcinoma, the optimal surgical treatment is en bloc resection with ipsilateral thyroid lobectomy and removal of any enlarged or abnormal lymph nodes. Surgery is the only curative treatment. In our patient, prompt surgical intervention proved successful. At six months the patient is well with no evidence of disease recurrence. This case highlights the importance of considering a hyperparathyroid storm in the context of a parathyroid carcinoma. Parathyroid carcinoma is a rare entity and our knowledge is mainly derived from case reports and retrospective studies. This case report increases awareness of this serious and life-threatening complication. This report also illustrates how prompt and appropriate management provides the best outcome for the patient.-
dc.language.isoenen
dc.titleThe management of acute parathyroid crisis secondary to parathyroid carcinoma: a case report.en
dc.contributor.departmentSurgical Professorial Unit, Saint Vincent's University Hospital, Dublin 4, Ireland. kathyrock2@hotmail.com.en
dc.identifier.journalJournal of medical case reportsen

Related articles on PubMed

All Items in Lenus, The Irish Health Repository are protected by copyright, with all rights reserved, unless otherwise indicated.