Visual sensory processing deficits in patients with bipolar disorder revealed through high-density electrical mapping.

Hdl Handle:
http://hdl.handle.net/10147/93846
Title:
Visual sensory processing deficits in patients with bipolar disorder revealed through high-density electrical mapping.
Authors:
Yeap, Sherlyn; Kelly, Simon P; Reilly, Richard B; Thakore, Jogin H; Foxe, John J
Affiliation:
The Cognitive Neurophysiology Laboratory, St. Vincent's Hospital, Richmond Road, Fairview, Dublin, Republic of Ireland.
Citation:
Visual sensory processing deficits in patients with bipolar disorder revealed through high-density electrical mapping. 2009, 34 (6):459-64 J Psychiatry Neurosci
Journal:
Journal of psychiatry & neuroscience : JPN
Issue Date:
Nov-2009
URI:
http://hdl.handle.net/10147/93846
PubMed ID:
19949722
Abstract:
BACKGROUND: Etiological commonalities are apparent between bipolar disorder and schizophrenia. For example, it is becoming clear that both populations show similar electrophysiological deficits in the auditory domain. Recent studies have also shown robust visual sensory processing deficits in patients with schizophrenia using the event-related potential technique, but this has not been formally tested in those with bipolar disorder. Our goal here was to assess whether early visual sensory processing in patients with bipolar disorder, as indexed by decreased amplitude of the P1 component of the visual evoked potential (VEP), would show a similar deficit to that seen in those with schizophrenia. Since the P1 deficit has already been established as an endophenotype in schizophrenia, a finding of commonality between disorders would raise the possibility that it represents a measure of common genetic liability. METHODS: We visually presented isolated-check stimuli to euthymic patients with a diagnosis of bipolar disorder and age-matched healthy controls within a simple go/no-go task and recorded VEPs using high-density (72-channel) electroencephalography. RESULTS: The P1 VEP amplitude was substantially reduced in patients with bipolar disorder, with an effect size of f = 0.56 (large according to Cohen's criteria). LIMITATIONS: Our sample size was relatively small and as such, did not allow for an examination of potential relations between the physiologic measures and clinical measures. CONCLUSION: This reduction in P1 amplitude among patients with bipolar disorder represents a dysfunction in early visual processing that is highly similar to that found repeatedly in patients with schizophrenia and their healthy first-degree relatives. Since the P1 deficit has been related to susceptibility genes for schizophrenia, our results raise the possibility that the deficit may in fact be more broadly related to the development of psychosis and that it merits further investigation as a candidate endophenotype for bipolar disorder.
Language:
en
MeSH:
Adult; Bipolar Disorder; Brain Mapping; Electroencephalography; Electrophysiology; Female; Humans; Male; Middle Aged; Photic Stimulation; Psychiatric Status Rating Scales; Psychomotor Performance; Visual Perception; Young Adult
ISSN:
1488-2434

Full metadata record

DC FieldValue Language
dc.contributor.authorYeap, Sherlynen
dc.contributor.authorKelly, Simon Pen
dc.contributor.authorReilly, Richard Ben
dc.contributor.authorThakore, Jogin Hen
dc.contributor.authorFoxe, John Jen
dc.date.accessioned2010-03-08T13:10:13Z-
dc.date.available2010-03-08T13:10:13Z-
dc.date.issued2009-11-
dc.identifier.citationVisual sensory processing deficits in patients with bipolar disorder revealed through high-density electrical mapping. 2009, 34 (6):459-64 J Psychiatry Neuroscien
dc.identifier.issn1488-2434-
dc.identifier.pmid19949722-
dc.identifier.urihttp://hdl.handle.net/10147/93846-
dc.description.abstractBACKGROUND: Etiological commonalities are apparent between bipolar disorder and schizophrenia. For example, it is becoming clear that both populations show similar electrophysiological deficits in the auditory domain. Recent studies have also shown robust visual sensory processing deficits in patients with schizophrenia using the event-related potential technique, but this has not been formally tested in those with bipolar disorder. Our goal here was to assess whether early visual sensory processing in patients with bipolar disorder, as indexed by decreased amplitude of the P1 component of the visual evoked potential (VEP), would show a similar deficit to that seen in those with schizophrenia. Since the P1 deficit has already been established as an endophenotype in schizophrenia, a finding of commonality between disorders would raise the possibility that it represents a measure of common genetic liability. METHODS: We visually presented isolated-check stimuli to euthymic patients with a diagnosis of bipolar disorder and age-matched healthy controls within a simple go/no-go task and recorded VEPs using high-density (72-channel) electroencephalography. RESULTS: The P1 VEP amplitude was substantially reduced in patients with bipolar disorder, with an effect size of f = 0.56 (large according to Cohen's criteria). LIMITATIONS: Our sample size was relatively small and as such, did not allow for an examination of potential relations between the physiologic measures and clinical measures. CONCLUSION: This reduction in P1 amplitude among patients with bipolar disorder represents a dysfunction in early visual processing that is highly similar to that found repeatedly in patients with schizophrenia and their healthy first-degree relatives. Since the P1 deficit has been related to susceptibility genes for schizophrenia, our results raise the possibility that the deficit may in fact be more broadly related to the development of psychosis and that it merits further investigation as a candidate endophenotype for bipolar disorder.-
dc.language.isoenen
dc.subject.meshAdult-
dc.subject.meshBipolar Disorder-
dc.subject.meshBrain Mapping-
dc.subject.meshElectroencephalography-
dc.subject.meshElectrophysiology-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshPhotic Stimulation-
dc.subject.meshPsychiatric Status Rating Scales-
dc.subject.meshPsychomotor Performance-
dc.subject.meshVisual Perception-
dc.subject.meshYoung Adult-
dc.titleVisual sensory processing deficits in patients with bipolar disorder revealed through high-density electrical mapping.en
dc.contributor.departmentThe Cognitive Neurophysiology Laboratory, St. Vincent's Hospital, Richmond Road, Fairview, Dublin, Republic of Ireland.en
dc.identifier.journalJournal of psychiatry & neuroscience : JPNen

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