Prolonged rote learning produces delayed memory facilitation and metabolic changes in the hippocampus of the ageing human brain.

Hdl Handle:
http://hdl.handle.net/10147/93844
Title:
Prolonged rote learning produces delayed memory facilitation and metabolic changes in the hippocampus of the ageing human brain.
Authors:
Roche, Richard Ap; Mullally, Sinéad L; McNulty, Jonathan P; Hayden, Judy; Brennan, Paul; Doherty, Colin P; Fitzsimons, Mary; McMackin, Deirdre; Prendergast, Julie; Sukumaran, Sunita; Mangaoang, Maeve A; Robertson, Ian H; O'Mara, Shane M
Affiliation:
School of Psychology & Trinity College Institute of Neuroscience, University of Dublin, Trinity College, Dublin 2, Ireland. Richard.Roche@nuim.ie
Citation:
Prolonged rote learning produces delayed memory facilitation and metabolic changes in the hippocampus of the ageing human brain. 2009, 10:136 BMC Neurosci
Journal:
BMC neuroscience
Issue Date:
2009
URI:
http://hdl.handle.net/10147/93844
DOI:
10.1186/1471-2202-10-136
PubMed ID:
19930568
Abstract:
BACKGROUND: Repeated rehearsal is one method by which verbal material may be transferred from short- to long-term memory. We hypothesised that extended engagement of memory structures through prolonged rehearsal would result in enhanced efficacy of recall and also of brain structures implicated in new learning. Twenty-four normal participants aged 55-70 (mean = 60.1) engaged in six weeks of rote learning, during which they learned 500 words per week every week (prose, poetry etc.). An extensive battery of memory tests was administered on three occasions, each six weeks apart. In addition, proton magnetic resonance spectroscopy (1H-MRS) was used to measure metabolite levels in seven voxels of interest (VOIs) (including hippocampus) before and after learning. RESULTS: Results indicate a facilitation of new learning that was evident six weeks after rote learning ceased. This facilitation occurred for verbal/episodic material only, and was mirrored by a metabolic change in left posterior hippocampus, specifically an increase in NAA/(Cr+Cho) ratio. CONCLUSION: Results suggest that repeated activation of memory structures facilitates anamnesis and may promote neuronal plasticity in the ageing brain, and that compliance is a key factor in such facilitation as the effect was confined to those who engaged fully with the training.
Language:
en
MeSH:
Aged; Aging; Analysis of Variance; Female; Functional Laterality; Hippocampus; Humans; Magnetic Resonance Spectroscopy; Male; Mental Recall; Middle Aged; Neuronal Plasticity; Neuropsychological Tests; Patient Selection; Practice (Psychology); Questionnaires; Signal Processing, Computer-Assisted; Spatial Behavior; Verbal Behavior
ISSN:
1471-2202

Full metadata record

DC FieldValue Language
dc.contributor.authorRoche, Richard Apen
dc.contributor.authorMullally, Sinéad Len
dc.contributor.authorMcNulty, Jonathan Pen
dc.contributor.authorHayden, Judyen
dc.contributor.authorBrennan, Paulen
dc.contributor.authorDoherty, Colin Pen
dc.contributor.authorFitzsimons, Maryen
dc.contributor.authorMcMackin, Deirdreen
dc.contributor.authorPrendergast, Julieen
dc.contributor.authorSukumaran, Sunitaen
dc.contributor.authorMangaoang, Maeve Aen
dc.contributor.authorRobertson, Ian Hen
dc.contributor.authorO'Mara, Shane Men
dc.date.accessioned2010-03-08T13:09:39Z-
dc.date.available2010-03-08T13:09:39Z-
dc.date.issued2009-
dc.identifier.citationProlonged rote learning produces delayed memory facilitation and metabolic changes in the hippocampus of the ageing human brain. 2009, 10:136 BMC Neuroscien
dc.identifier.issn1471-2202-
dc.identifier.pmid19930568-
dc.identifier.doi10.1186/1471-2202-10-136-
dc.identifier.urihttp://hdl.handle.net/10147/93844-
dc.description.abstractBACKGROUND: Repeated rehearsal is one method by which verbal material may be transferred from short- to long-term memory. We hypothesised that extended engagement of memory structures through prolonged rehearsal would result in enhanced efficacy of recall and also of brain structures implicated in new learning. Twenty-four normal participants aged 55-70 (mean = 60.1) engaged in six weeks of rote learning, during which they learned 500 words per week every week (prose, poetry etc.). An extensive battery of memory tests was administered on three occasions, each six weeks apart. In addition, proton magnetic resonance spectroscopy (1H-MRS) was used to measure metabolite levels in seven voxels of interest (VOIs) (including hippocampus) before and after learning. RESULTS: Results indicate a facilitation of new learning that was evident six weeks after rote learning ceased. This facilitation occurred for verbal/episodic material only, and was mirrored by a metabolic change in left posterior hippocampus, specifically an increase in NAA/(Cr+Cho) ratio. CONCLUSION: Results suggest that repeated activation of memory structures facilitates anamnesis and may promote neuronal plasticity in the ageing brain, and that compliance is a key factor in such facilitation as the effect was confined to those who engaged fully with the training.-
dc.language.isoenen
dc.subject.meshAged-
dc.subject.meshAging-
dc.subject.meshAnalysis of Variance-
dc.subject.meshFemale-
dc.subject.meshFunctional Laterality-
dc.subject.meshHippocampus-
dc.subject.meshHumans-
dc.subject.meshMagnetic Resonance Spectroscopy-
dc.subject.meshMale-
dc.subject.meshMental Recall-
dc.subject.meshMiddle Aged-
dc.subject.meshNeuronal Plasticity-
dc.subject.meshNeuropsychological Tests-
dc.subject.meshPatient Selection-
dc.subject.meshPractice (Psychology)-
dc.subject.meshQuestionnaires-
dc.subject.meshSignal Processing, Computer-Assisted-
dc.subject.meshSpatial Behavior-
dc.subject.meshVerbal Behavior-
dc.titleProlonged rote learning produces delayed memory facilitation and metabolic changes in the hippocampus of the ageing human brain.en
dc.contributor.departmentSchool of Psychology & Trinity College Institute of Neuroscience, University of Dublin, Trinity College, Dublin 2, Ireland. Richard.Roche@nuim.ieen
dc.identifier.journalBMC neuroscienceen

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