Tight junctions: a barrier to the initiation and progression of breast cancer?

Hdl Handle:
http://hdl.handle.net/10147/93822
Title:
Tight junctions: a barrier to the initiation and progression of breast cancer?
Authors:
Brennan, Kieran; Offiah, Gozie; McSherry, Elaine A; Hopkins, Ann M
Affiliation:
Department of Surgery, Royal College of Surgeons in Ireland, Dublin, Ireland.
Citation:
Tight junctions: a barrier to the initiation and progression of breast cancer? 2010, 2010:460607 J. Biomed. Biotechnol.
Journal:
Journal of biomedicine & biotechnology
Issue Date:
2010
URI:
http://hdl.handle.net/10147/93822
DOI:
10.1155/2010/460607
PubMed ID:
19920867
Abstract:
Breast cancer is a complex and heterogeneous disease that arises from epithelial cells lining the breast ducts and lobules. Correct adhesion between adjacent epithelial cells is important in determining the normal structure and function of epithelial tissues, and there is accumulating evidence that dysregulated cell-cell adhesion is associated with many cancers. This review will focus on one cell-cell adhesion complex, the tight junction (TJ), and summarize recent evidence that TJs may participate in breast cancer development or progression. We will first outline the protein composition of TJs and discuss the functions of the TJ complex. Secondly we will examine how alterations in these functions might facilitate breast cancer initiation or progression; by focussing on the regulatory influence of TJs on cell polarity, cell fate and cell migration. Finally we will outline how pharmacological targeting of TJ proteins may be useful in limiting breast cancer progression. Overall we hope to illustrate that the relationship between TJ alterations and breast cancer is a complex one; but that this area offers promise in uncovering fundamental mechanisms linked to breast cancer progression.
Language:
en
MeSH:
Breast Neoplasms; Cell Adhesion; Disease Progression; Female; Humans; Precancerous Conditions; Tight Junctions
ISSN:
1110-7251

Full metadata record

DC FieldValue Language
dc.contributor.authorBrennan, Kieranen
dc.contributor.authorOffiah, Gozieen
dc.contributor.authorMcSherry, Elaine Aen
dc.contributor.authorHopkins, Ann Men
dc.date.accessioned2010-03-08T13:09:17Z-
dc.date.available2010-03-08T13:09:17Z-
dc.date.issued2010-
dc.identifier.citationTight junctions: a barrier to the initiation and progression of breast cancer? 2010, 2010:460607 J. Biomed. Biotechnol.en
dc.identifier.issn1110-7251-
dc.identifier.pmid19920867-
dc.identifier.doi10.1155/2010/460607-
dc.identifier.urihttp://hdl.handle.net/10147/93822-
dc.description.abstractBreast cancer is a complex and heterogeneous disease that arises from epithelial cells lining the breast ducts and lobules. Correct adhesion between adjacent epithelial cells is important in determining the normal structure and function of epithelial tissues, and there is accumulating evidence that dysregulated cell-cell adhesion is associated with many cancers. This review will focus on one cell-cell adhesion complex, the tight junction (TJ), and summarize recent evidence that TJs may participate in breast cancer development or progression. We will first outline the protein composition of TJs and discuss the functions of the TJ complex. Secondly we will examine how alterations in these functions might facilitate breast cancer initiation or progression; by focussing on the regulatory influence of TJs on cell polarity, cell fate and cell migration. Finally we will outline how pharmacological targeting of TJ proteins may be useful in limiting breast cancer progression. Overall we hope to illustrate that the relationship between TJ alterations and breast cancer is a complex one; but that this area offers promise in uncovering fundamental mechanisms linked to breast cancer progression.-
dc.language.isoenen
dc.subject.meshBreast Neoplasms-
dc.subject.meshCell Adhesion-
dc.subject.meshDisease Progression-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshPrecancerous Conditions-
dc.subject.meshTight Junctions-
dc.titleTight junctions: a barrier to the initiation and progression of breast cancer?en
dc.contributor.departmentDepartment of Surgery, Royal College of Surgeons in Ireland, Dublin, Ireland.en
dc.identifier.journalJournal of biomedicine & biotechnologyen

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