Phenotypic characterization of lymphocytes in HCV/HIV co-infected patients.

Hdl Handle:
http://hdl.handle.net/10147/76817
Title:
Phenotypic characterization of lymphocytes in HCV/HIV co-infected patients.
Authors:
Roe, Barbara; Coughlan, Suzie; Dean, Jonathan; Lambert, John S; Keating, Shay; Norris, Suzanne; Bergin, Colm; Hall, William W
Affiliation:
Centre for Research in Infectious Diseases, University College Dublin, Ireland.
Citation:
Phenotypic characterization of lymphocytes in HCV/HIV co-infected patients. 2009, 22 (1):39-48 Viral Immunol.
Journal:
Viral immunology
Issue Date:
Feb-2009
URI:
http://hdl.handle.net/10147/76817
DOI:
10.1089/vim.2008.0074
PubMed ID:
19210227
Abstract:
While hepatitis C virus (HCV)-specific immune responses are attenuated in HCV/HIV co-infected patients compared to those infected with HCV alone, the reasons for this remain unclear. In this study, the proportions of regulatory, naïve, and memory T cells, along with chemokine receptor expression, were measured in co-infected and mono-infected patients to determine if there is an alteration in the phenotypic profile of lymphocytes in these patients. HCV/HIV co-infected patients had increased proportions of CD4(+) naïve cells and decreased proportions of CD4(+) effector cells when compared to HCV mono-infected patients. The proportions of CD4(+) Tregs and CD4(+) CXCR3(+) T cells were also significantly lower in co-infected patients. A decrease in CD4(+) Tregs and subsequent loss of immunosuppressive function may contribute to the accelerated progression to liver disease in co-infected individuals. Dysregulation of immune responses following reduction in the proportions of CD4(+) CXCR3(+) Th-1 cells may contribute to the reduced functional capacity of HCV-specific immune responses in co-infected patients. The findings of this study provide new information on the T-cell immunophenotype in HCV/HIV co-infected patients when compared to those infected with HCV alone, and may provide insight into why cell-mediated immune responses are diminished during HCV infection.
Item Type:
Article
Language:
en
MeSH:
Adult; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Female; HIV Infections; HIV-1; Hepacivirus; Hepatitis C; Humans; Immunophenotyping; Male; Middle Aged; T-Lymphocytes; T-Lymphocytes, Regulatory; Young Adult
ISSN:
1557-8976

Full metadata record

DC FieldValue Language
dc.contributor.authorRoe, Barbara-
dc.contributor.authorCoughlan, Suzie-
dc.contributor.authorDean, Jonathan-
dc.contributor.authorLambert, John S-
dc.contributor.authorKeating, Shay-
dc.contributor.authorNorris, Suzanne-
dc.contributor.authorBergin, Colm-
dc.contributor.authorHall, William W-
dc.date.accessioned2009-08-10T14:50:18Z-
dc.date.available2009-08-10T14:50:18Z-
dc.date.issued2009-02-
dc.identifier.citationPhenotypic characterization of lymphocytes in HCV/HIV co-infected patients. 2009, 22 (1):39-48 Viral Immunol.en
dc.identifier.issn1557-8976-
dc.identifier.pmid19210227-
dc.identifier.doi10.1089/vim.2008.0074-
dc.identifier.urihttp://hdl.handle.net/10147/76817-
dc.description.abstractWhile hepatitis C virus (HCV)-specific immune responses are attenuated in HCV/HIV co-infected patients compared to those infected with HCV alone, the reasons for this remain unclear. In this study, the proportions of regulatory, naïve, and memory T cells, along with chemokine receptor expression, were measured in co-infected and mono-infected patients to determine if there is an alteration in the phenotypic profile of lymphocytes in these patients. HCV/HIV co-infected patients had increased proportions of CD4(+) naïve cells and decreased proportions of CD4(+) effector cells when compared to HCV mono-infected patients. The proportions of CD4(+) Tregs and CD4(+) CXCR3(+) T cells were also significantly lower in co-infected patients. A decrease in CD4(+) Tregs and subsequent loss of immunosuppressive function may contribute to the accelerated progression to liver disease in co-infected individuals. Dysregulation of immune responses following reduction in the proportions of CD4(+) CXCR3(+) Th-1 cells may contribute to the reduced functional capacity of HCV-specific immune responses in co-infected patients. The findings of this study provide new information on the T-cell immunophenotype in HCV/HIV co-infected patients when compared to those infected with HCV alone, and may provide insight into why cell-mediated immune responses are diminished during HCV infection.-
dc.language.isoenen
dc.subject.meshAdult-
dc.subject.meshCD4-Positive T-Lymphocytes-
dc.subject.meshCD8-Positive T-Lymphocytes-
dc.subject.meshFemale-
dc.subject.meshHIV Infections-
dc.subject.meshHIV-1-
dc.subject.meshHepacivirus-
dc.subject.meshHepatitis C-
dc.subject.meshHumans-
dc.subject.meshImmunophenotyping-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshT-Lymphocytes-
dc.subject.meshT-Lymphocytes, Regulatory-
dc.subject.meshYoung Adult-
dc.titlePhenotypic characterization of lymphocytes in HCV/HIV co-infected patients.en
dc.typeArticleen
dc.contributor.departmentCentre for Research in Infectious Diseases, University College Dublin, Ireland.en
dc.identifier.journalViral immunologyen

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