Nodular fasciitis: A pseudomalignant clonal neoplasm characterized by USP gene rearrangements and spontaneous regression
Authors
Hennebry, JenniferMulholland, Douglas
Tchrakian, Nairi
Martin Gillham, Charles
Julian Beddy, Peter
Mai O'Donnell, Dearbhaile
Eibhlín McMenamin, Máirín
Issue Date
2017-01Keywords
NEOPLASMSNODULAR FACIITIS
Metadata
Show full item recordCitation
Nodular fasciitis: A pseudomalignant clonal neoplasm characterized by USP gene rearrangements and spontaneous regression 2017, 8 (01):80 International Journal of Case Reports and ImagesPublisher
Edorium JournalsJournal
International Journal of Case Reports and ImagesDOI
10.5348/ijcri-201713-CR-10752Additional Links
http://www.ijcasereportsandimages.com/archive/2017/001-2017-ijcri/CR-10752-01-2017-hennebry/ijcri-1075201201752-hennebry-full-text.phpAbstract
Introduction: Nodular fasciitis (NF) is a rapidly growing, self-limited, myofibroblastic neoplasm that typically arises in subcutaneous tissues of young adults and regresses spontaneously. Nodular fasciitis mimics sarcoma on clinical, radiological, and histological grounds and is usually, diagnosed following excision. Case Report: A 26-year-old female presented at surveillance computed tomography (CT) scan one year post-treatment for stage 1c ovarian dysgerminoma with a 4 cm axillary soft tissue mass, radiologically suspicious for metastasis with subclavian vein invasion. Histopathology of core biopsies favored NF, confirmed by detection of USP6 gene rearrangements by FISH analysis. This case describes an unusual relatively deep NF, suspicious for metastasis on CT scan with confirmed spontaneous regression over two years. Conclusion: Nodular fasciitis should be considered in the differential diagnosis of rapidly growing enhancing soft tissue masses. Molecular cytogenetic testing of USP6 gene rearrangements allows definitive diagnosis on core biopsies in challenging cases, permitting a conservative approach and avoiding potentially radical and unnecessary surgery.Item Type
ArticleLanguage
enISSN
0976-3198ae974a485f413a2113503eed53cd6c53
10.5348/ijcri-201713-CR-10752