Gestational Age at Birth and 'Body-Mind' Health at 5 Years of Age: A Population Based Cohort Study.
Authors
Cronin, Frances MSegurado, Ricardo
McAuliffe, Fionnuala M
Kelleher, Cecily C
Tremblay, Richard E
Issue Date
2016Keywords
NEONATEPREMATURE BIRTH
WELLBEING
HEALTH STATUS
MeSH
Child DevelopmentChild, Preschool
Female
Follow-Up Studies
Gestational Age
Humans
Infant
Infant, Newborn
Male
Mental Health
Metadata
Show full item recordCitation
Gestational Age at Birth and 'Body-Mind' Health at 5 Years of Age: A Population Based Cohort Study. 2016, 11 (3):e0151222 PLoS ONEJournal
PloS oneDOI
10.1371/journal.pone.0151222PubMed ID
26975048Abstract
Numerous studies have identified the effects of prematurity on the neonate's physical health, however few studies have explored the effects of prematurity on both the physical and mental health of the child as they develop. Secondary analysis of data from the Millennium Cohort Study, a longitudinal study of infants (n = 18 818, born 2000-2002 in the United Kingdom) was performed. Effects of gestational age at birth on health outcomes at 5 years were measured using parental rating of their children's general health and severity of behavior problems. The association between parent's general health ratings and behavior problem ratings was low: 86% of those reporting serious behavior problems (5% of the sample, n = 764) rated their child as being in excellent, very good, or good health. Still, a gradient of increasing risk of poorer outcome with decreasing gestational age was observed for a composite health measure (poor/fair health and/or serious behavior problems), suggesting an association with prematurity for this composite assessment of health status. The greatest contribution to the childhood composite health measure at 5 years was for children born at 32-36 weeks gestation: population attributable fractions for having poor outcomes was 3.4% (Bonferroni-adjusted 95% confidence interval 1.1%-6.2%), compared to 1% (0.2-2.3) for birth at less than 32 weeks. Results suggest that preterm children, by school entry, are not only at high risk of physical health problems, but also of behavioral health problems. The recognition of, and response to comprehensive health and well-being outcomes related to prematurity are important in order to correctly plan and deliver adequate paediatric health services and policies.Item Type
ArticleLanguage
enISSN
1932-6203Sponsors
Funder:HRA_PHS/2011/35ae974a485f413a2113503eed53cd6c53
10.1371/journal.pone.0151222
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