LC3B globular structures correlate with survival in esophageal adenocarcinoma.

Hdl Handle:
http://hdl.handle.net/10147/620600
Title:
LC3B globular structures correlate with survival in esophageal adenocarcinoma.
Authors:
El-Mashed, Shereen; O'Donovan, Tracey R; Kay, Elaine W; Abdallah, Ayat R; Cathcart, Mary-Clare; O'Sullivan, Jacintha; O'Grady, Anthony; Reynolds, John; O'Reilly, Seamus; O'Sullivan, Gerald C; McKenna, Sharon L
Citation:
LC3B globular structures correlate with survival in esophageal adenocarcinoma. 2015, 15:582 BMC Cancer
Journal:
BMC cancer
Issue Date:
2015
URI:
http://hdl.handle.net/10147/620600
DOI:
10.1186/s12885-015-1574-5
PubMed ID:
26265176
Additional Links:
http://bmccancer.biomedcentral.com/articles/10.1186/s12885-015-1574-5
Abstract:
Esophageal adenocarcinoma has the fastest growing incidence of any solid tumor in the Western world. Prognosis remains poor with overall five-year survival rates under 25 %. Only a limited number of patients benefit from chemotherapy and there are no biomarkers that can predict outcome. Previous studies have indicated that induction of autophagy can influence various aspects of tumor cell biology, including chemosensitivity. The objective of this study was to assess whether expression of the autophagy marker (LC3B) correlated with patient outcome.
Item Type:
Article
Language:
en
Keywords:
CANCER, OESOPAHGEAL
MeSH:
Autophagy; Biomarkers, Tumor; Cell Line, Tumor; Esophageal Neoplasms; Humans; Microtubule-Associated Proteins; Prognosis; Retrospective Studies; Survival Analysis
ISSN:
1471-2407
Sponsors:
This work was funded by the Egyptian Education Bureau. We are also grateful to the Higher Education Authority of Ireland and Breakthrough Cancer Research for financial support.

Full metadata record

DC FieldValue Language
dc.contributor.authorEl-Mashed, Shereenen
dc.contributor.authorO'Donovan, Tracey Ren
dc.contributor.authorKay, Elaine Wen
dc.contributor.authorAbdallah, Ayat Ren
dc.contributor.authorCathcart, Mary-Clareen
dc.contributor.authorO'Sullivan, Jacinthaen
dc.contributor.authorO'Grady, Anthonyen
dc.contributor.authorReynolds, Johnen
dc.contributor.authorO'Reilly, Seamusen
dc.contributor.authorO'Sullivan, Gerald Cen
dc.contributor.authorMcKenna, Sharon Len
dc.date.accessioned2016-09-20T11:55:59Z-
dc.date.available2016-09-20T11:55:59Z-
dc.date.issued2015-
dc.identifier.citationLC3B globular structures correlate with survival in esophageal adenocarcinoma. 2015, 15:582 BMC Canceren
dc.identifier.issn1471-2407-
dc.identifier.pmid26265176-
dc.identifier.doi10.1186/s12885-015-1574-5-
dc.identifier.urihttp://hdl.handle.net/10147/620600-
dc.description.abstractEsophageal adenocarcinoma has the fastest growing incidence of any solid tumor in the Western world. Prognosis remains poor with overall five-year survival rates under 25 %. Only a limited number of patients benefit from chemotherapy and there are no biomarkers that can predict outcome. Previous studies have indicated that induction of autophagy can influence various aspects of tumor cell biology, including chemosensitivity. The objective of this study was to assess whether expression of the autophagy marker (LC3B) correlated with patient outcome.en
dc.description.sponsorshipThis work was funded by the Egyptian Education Bureau. We are also grateful to the Higher Education Authority of Ireland and Breakthrough Cancer Research for financial support.en
dc.language.isoenen
dc.relation.urlhttp://bmccancer.biomedcentral.com/articles/10.1186/s12885-015-1574-5en
dc.rightsArchived with thanks to BMC canceren
dc.subjectCANCER, OESOPAHGEALen
dc.subject.meshAutophagy-
dc.subject.meshBiomarkers, Tumor-
dc.subject.meshCell Line, Tumor-
dc.subject.meshEsophageal Neoplasms-
dc.subject.meshHumans-
dc.subject.meshMicrotubule-Associated Proteins-
dc.subject.meshPrognosis-
dc.subject.meshRetrospective Studies-
dc.subject.meshSurvival Analysis-
dc.titleLC3B globular structures correlate with survival in esophageal adenocarcinoma.en
dc.typeArticleen
dc.identifier.journalBMC canceren
dc.description.fundingOtheren
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen

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