Which organ is responsible for the pathogenesis of obesity

Hdl Handle:
http://hdl.handle.net/10147/620588
Title:
Which organ is responsible for the pathogenesis of obesity
Authors:
Melvin, A; le Roux, CW; Docherty, NG
Publisher:
Irish Medical Journal
Journal:
Irish Medical Journal
Issue Date:
Apr-2016
URI:
http://hdl.handle.net/10147/620588
Additional Links:
http://www.imj.ie
Item Type:
Article
Language:
en
Description:
Obesity is associated with significant complications and healthcare costs, but our ability to treat obesity has been limited by our understanding of its pathogenesis. We surveyed diabetologists and obesity related health care professionals asking them which organ they believed to be responsible for the pathogenesis of obesity. Participants favoured a central nervous system (CNS) aetiology. The response echoes evidence from genome wide association studies identifying a link between obesity and CNS loci. Our most successful obesity therapies involve the manipulation of subcortical area of the brain involved in energy balance. Future success in the management of obesity will be determined by our ability to define the pathogenesis of the disease in individual cases, moving from a “one size fits all” to more focused interventions
Keywords:
OBESITY

Full metadata record

DC FieldValue Language
dc.contributor.authorMelvin, Aen
dc.contributor.authorle Roux, CWen
dc.contributor.authorDocherty, NGen
dc.date.accessioned2016-09-21T11:02:33Z-
dc.date.available2016-09-21T11:02:33Z-
dc.date.issued2016-04-
dc.identifier.urihttp://hdl.handle.net/10147/620588-
dc.descriptionObesity is associated with significant complications and healthcare costs, but our ability to treat obesity has been limited by our understanding of its pathogenesis. We surveyed diabetologists and obesity related health care professionals asking them which organ they believed to be responsible for the pathogenesis of obesity. Participants favoured a central nervous system (CNS) aetiology. The response echoes evidence from genome wide association studies identifying a link between obesity and CNS loci. Our most successful obesity therapies involve the manipulation of subcortical area of the brain involved in energy balance. Future success in the management of obesity will be determined by our ability to define the pathogenesis of the disease in individual cases, moving from a “one size fits all” to more focused interventionsen
dc.language.isoenen
dc.publisherIrish Medical Journalen
dc.relation.urlhttp://www.imj.ieen
dc.subjectOBESITYen
dc.titleWhich organ is responsible for the pathogenesis of obesityen
dc.typeArticleen
dc.identifier.journalIrish Medical Journalen
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