Pagets disease of bone: progress towards remission and prevention

Hdl Handle:
http://hdl.handle.net/10147/597127
Title:
Pagets disease of bone: progress towards remission and prevention
Authors:
Healy, GM; Woods, C; Heffernan, E; McKenna, MJ
Publisher:
Irish Medical Journal
Journal:
Irish Medical Journal
Issue Date:
Dec-2015
URI:
http://hdl.handle.net/10147/597127
Item Type:
Article
Language:
en
Description:
Paget s disease of bone is a focal disorder of bone remodelling leading to areas of enlarged weakened bone manifesting with chronic pain, bone deformity, and fracture. Predominantly a disease of older adults, its prevalence is strongly linked to European ancestry. Pre-disposing factors include exposure to viruses such as measles and mutations in the SQSTM1 gene. PDB is diagnosed on plain radiograph, the extent of disease is delineated by radionuclide bone imaging, the degree of activity is quantified biochemically, and it is treated with a nitrogen-containing bisphosphonate, most effectively by a single intravenous infusion of zoledronate 5mg. Lifelong specialist follow-up is advocated because some patients require repeated infusions. Current clinical research is focusing on genetic factors in order to identify patients suitable for prevention.
Keywords:
PAIN MANAGEMENT
Local subject classification:
BONE DISEASE; CHRONIC PAIN

Full metadata record

DC FieldValue Language
dc.contributor.authorHealy, GMen
dc.contributor.authorWoods, Cen
dc.contributor.authorHeffernan, Een
dc.contributor.authorMcKenna, MJen
dc.date.accessioned2016-02-24T14:43:14Zen
dc.date.available2016-02-24T14:43:14Zen
dc.date.issued2015-12en
dc.identifier.urihttp://hdl.handle.net/10147/597127en
dc.descriptionPaget s disease of bone is a focal disorder of bone remodelling leading to areas of enlarged weakened bone manifesting with chronic pain, bone deformity, and fracture. Predominantly a disease of older adults, its prevalence is strongly linked to European ancestry. Pre-disposing factors include exposure to viruses such as measles and mutations in the SQSTM1 gene. PDB is diagnosed on plain radiograph, the extent of disease is delineated by radionuclide bone imaging, the degree of activity is quantified biochemically, and it is treated with a nitrogen-containing bisphosphonate, most effectively by a single intravenous infusion of zoledronate 5mg. Lifelong specialist follow-up is advocated because some patients require repeated infusions. Current clinical research is focusing on genetic factors in order to identify patients suitable for prevention.en
dc.language.isoenen
dc.publisherIrish Medical Journalen
dc.subjectPAIN MANAGEMENTen
dc.subject.otherBONE DISEASEen
dc.subject.otherCHRONIC PAINen
dc.titlePagets disease of bone: progress towards remission and preventionen
dc.typeArticleen
dc.identifier.journalIrish Medical Journalen
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