Stereotactic Radiotherapy in the Management of Epilepsy

Hdl Handle:
http://hdl.handle.net/10147/583460
Title:
Stereotactic Radiotherapy in the Management of Epilepsy
Authors:
Vernimmen, Frederik; Samuji, MS Mat
Citation:
Stereotactic Radiotherapy in the Management of Epilepsy 2014, 01 (02) International Journal of Neurorehabilitation
Publisher:
International Journal of Neurorehabilitation
Journal:
International Journal of Neurorehabilitation
Issue Date:
2014
URI:
http://hdl.handle.net/10147/583460
DOI:
10.4172/2376-0281.1000118
Additional Links:
http://www.omicsgroup.org/journals/stereotactic-radiotherapy-in-the-management-of-epilepsy-2376-0281-1000118.php?aid=32019
Abstract:
Although the main stay of epileptic therapy is pharmacological certain forms of epilepsy such as temporal lobe epilepsy and epilepsy associated with benign diseases of the brain can also be successfully managed surgically. A neurosurgical procedure has the advantage of an immediate therapeutic result. When surgery is not possible, therapeutic irradiation is an option, but there is always a latent time between the radiation and the improvement in the epilepsy. This radiation is under the form of photon radiation produced by Cobalt sources in a Gamma knife® or by Linear accelerators. Special beam collimation techniques produce a sharp beam allowing for a high dose to be delivered to the target without side effects on the normal surrounding brain. The desired therapeutic effect comes from the late radiation effects, and hence is not immediate. The absorption in tissue of photon radiation is such that there is always an exit dose, and this contributes to radiation side effects on normal tissue. Particle radiation beams such as a proton beam have a dose absorption advantage over photons because there is a lower entry dose and no exit dose. This has the potential to treat the brain with a lower risk of side effects, and a lower integral dose. Presently radiation dose selection is aimed at causing tissue destruction in the target volume. Dose schedules that do not cause tissue necrosis but have a neurophysiologic therapeutic effect are presently under investigation. New irradiation technologies such as micro photon beams using synchrotron radiation and mini proton beams are been studied especially for their potential in epilepsy therapy. These technologies could greatly improve the therapeutic ratio as they cause no damage to brain tissue. If proven to have a therapeutic effect these new developments would expand the role of radiation in managing epilepsy.
Item Type:
Article
Language:
en
Keywords:
EPILEPSY; SURGERY
ISSN:
23760281

Full metadata record

DC FieldValue Language
dc.contributor.authorVernimmen, Frederiken
dc.contributor.authorSamuji, MS Maten
dc.date.accessioned2015-12-09T10:03:51Zen
dc.date.available2015-12-09T10:03:51Zen
dc.date.issued2014en
dc.identifier.citationStereotactic Radiotherapy in the Management of Epilepsy 2014, 01 (02) International Journal of Neurorehabilitationen
dc.identifier.issn23760281en
dc.identifier.doi10.4172/2376-0281.1000118en
dc.identifier.urihttp://hdl.handle.net/10147/583460en
dc.description.abstractAlthough the main stay of epileptic therapy is pharmacological certain forms of epilepsy such as temporal lobe epilepsy and epilepsy associated with benign diseases of the brain can also be successfully managed surgically. A neurosurgical procedure has the advantage of an immediate therapeutic result. When surgery is not possible, therapeutic irradiation is an option, but there is always a latent time between the radiation and the improvement in the epilepsy. This radiation is under the form of photon radiation produced by Cobalt sources in a Gamma knife® or by Linear accelerators. Special beam collimation techniques produce a sharp beam allowing for a high dose to be delivered to the target without side effects on the normal surrounding brain. The desired therapeutic effect comes from the late radiation effects, and hence is not immediate. The absorption in tissue of photon radiation is such that there is always an exit dose, and this contributes to radiation side effects on normal tissue. Particle radiation beams such as a proton beam have a dose absorption advantage over photons because there is a lower entry dose and no exit dose. This has the potential to treat the brain with a lower risk of side effects, and a lower integral dose. Presently radiation dose selection is aimed at causing tissue destruction in the target volume. Dose schedules that do not cause tissue necrosis but have a neurophysiologic therapeutic effect are presently under investigation. New irradiation technologies such as micro photon beams using synchrotron radiation and mini proton beams are been studied especially for their potential in epilepsy therapy. These technologies could greatly improve the therapeutic ratio as they cause no damage to brain tissue. If proven to have a therapeutic effect these new developments would expand the role of radiation in managing epilepsy.en
dc.language.isoenen
dc.publisherInternational Journal of Neurorehabilitationen
dc.relation.urlhttp://www.omicsgroup.org/journals/stereotactic-radiotherapy-in-the-management-of-epilepsy-2376-0281-1000118.php?aid=32019en
dc.rightsArchived with thanks to International Journal of Neurorehabilitationen
dc.subjectEPILEPSYen
dc.subjectSURGERYen
dc.titleStereotactic Radiotherapy in the Management of Epilepsyen
dc.typeArticleen
dc.identifier.journalInternational Journal of Neurorehabilitationen
dc.description.fundingNo fundingen
dc.description.provinceMunsteren
dc.description.peer-reviewpeer-reviewen
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