Gold nanoparticles in stereotactic radiosurgery for cerebral arteriovenous malformations

Hdl Handle:
http://hdl.handle.net/10147/583458
Title:
Gold nanoparticles in stereotactic radiosurgery for cerebral arteriovenous malformations
Authors:
Vernimmen, Frederik; Shmatov, Mikhail L.
Citation:
Gold Nanoparticles in Stereotactic Radiosurgery for Cerebral Arteriovenous Malformations 2015, 06 (03):204 Journal of Biomaterials and Nanobiotechnology
Publisher:
Journal of Biomaterials and Nanobiotechnology
Journal:
Journal of Biomaterials and Nanobiotechnology
Issue Date:
Jul-2015
URI:
http://hdl.handle.net/10147/583458
DOI:
10.4236/jbnb.2015.63019
Additional Links:
http://www.scirp.org/journal/PaperDownload.aspx?DOI=10.4236/jbnb.2015.63019
Abstract:
Objective of the study: To explore the potential for therapeutic gain with gold nanoparticles in arteriovenous malformation radiosurgery based on their interaction with photons and protons. Study methods: Radiation dose enhancement resulting from the interaction of gold nanoparticles with irradiation ranging from kilovoltage to megavoltage photons and protons was researched in the literature. The role of angiogenesis and its regulation via vascular endothelial growth factors and cell membrane receptors, especially for endothelial cells in arteriovenous malformations, was investigated as a way for selective arteriovenous malformation deposition. Results: Radiation dose enhancement with gold nanoparticles is described in the literature but has so far only been investigated for its potential in treating malignancies. Because of the high atomic number of gold (Z = 79), dose enhancement occurs with photons mainly based on secondary photon and Auger electron production and the dose enhancement factor is the highest for irradiation with kilo voltage photons. Dose enhancement happens with megavoltage photons also but to a lesser extend and is mainly due to the ionization of gold by secondary photons and electrons generated by the megavoltage photons passing through tissue. The range of the secondary photo electrons emitted by gold is sufficient to cover the entire endothelial cell content. Protons interact with the production of Auger electrons which have a very short range, insufficient to cover the entire contents of endothelial cells, but sufficient to cause a high cell membrane dose for membrane located gold nanoparticles (AuNPs). Arteriovenous malformations are dynamic entities with angiogenesis taking place. This is reflected by a different expression of angiogenic receptors on the membrane of arteriovenous malformation endothelial cells compared to normal brain blood vessels, thereby opening the opportunity for selective deposition of such particles. For the use in proton therapy a new definition for the dose enhancement factor describing the local effect of nanoparticles is proposed. Conclusion: The concept of nanoparticle enhanced radiosurgery for arteriovenous malfor-
Item Type:
Article
Language:
en
Keywords:
SURGERY; RADIOTHERAPY
ISSN:
2158-7027; 2158-7043

Full metadata record

DC FieldValue Language
dc.contributor.authorVernimmen, Frederiken
dc.contributor.authorShmatov, Mikhail L.en
dc.date.accessioned2015-12-09T09:49:48Zen
dc.date.available2015-12-09T09:49:48Zen
dc.date.issued2015-07en
dc.identifier.citationGold Nanoparticles in Stereotactic Radiosurgery for Cerebral Arteriovenous Malformations 2015, 06 (03):204 Journal of Biomaterials and Nanobiotechnologyen
dc.identifier.issn2158-7027en
dc.identifier.issn2158-7043en
dc.identifier.doi10.4236/jbnb.2015.63019en
dc.identifier.urihttp://hdl.handle.net/10147/583458en
dc.description.abstractObjective of the study: To explore the potential for therapeutic gain with gold nanoparticles in arteriovenous malformation radiosurgery based on their interaction with photons and protons. Study methods: Radiation dose enhancement resulting from the interaction of gold nanoparticles with irradiation ranging from kilovoltage to megavoltage photons and protons was researched in the literature. The role of angiogenesis and its regulation via vascular endothelial growth factors and cell membrane receptors, especially for endothelial cells in arteriovenous malformations, was investigated as a way for selective arteriovenous malformation deposition. Results: Radiation dose enhancement with gold nanoparticles is described in the literature but has so far only been investigated for its potential in treating malignancies. Because of the high atomic number of gold (Z = 79), dose enhancement occurs with photons mainly based on secondary photon and Auger electron production and the dose enhancement factor is the highest for irradiation with kilo voltage photons. Dose enhancement happens with megavoltage photons also but to a lesser extend and is mainly due to the ionization of gold by secondary photons and electrons generated by the megavoltage photons passing through tissue. The range of the secondary photo electrons emitted by gold is sufficient to cover the entire endothelial cell content. Protons interact with the production of Auger electrons which have a very short range, insufficient to cover the entire contents of endothelial cells, but sufficient to cause a high cell membrane dose for membrane located gold nanoparticles (AuNPs). Arteriovenous malformations are dynamic entities with angiogenesis taking place. This is reflected by a different expression of angiogenic receptors on the membrane of arteriovenous malformation endothelial cells compared to normal brain blood vessels, thereby opening the opportunity for selective deposition of such particles. For the use in proton therapy a new definition for the dose enhancement factor describing the local effect of nanoparticles is proposed. Conclusion: The concept of nanoparticle enhanced radiosurgery for arteriovenous malfor-en
dc.language.isoenen
dc.publisherJournal of Biomaterials and Nanobiotechnologyen
dc.relation.urlhttp://www.scirp.org/journal/PaperDownload.aspx?DOI=10.4236/jbnb.2015.63019en
dc.rightsArchived with thanks to Journal of Biomaterials and Nanobiotechnologyen
dc.subjectSURGERYen
dc.subjectRADIOTHERAPYen
dc.titleGold nanoparticles in stereotactic radiosurgery for cerebral arteriovenous malformationsen
dc.typeArticleen
dc.identifier.journalJournal of Biomaterials and Nanobiotechnologyen
dc.description.fundingNo fundingen
dc.description.provinceMunsteren
dc.description.peer-reviewpeer-reviewen
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