Application of neurite orientation dispersion and density imaging (NODDI) to a tau pathology model of Alzheimer's disease.

Hdl Handle:
http://hdl.handle.net/10147/583447
Title:
Application of neurite orientation dispersion and density imaging (NODDI) to a tau pathology model of Alzheimer's disease.
Authors:
Colgan, N; Siow, B; O'Callaghan, J M; Harrison, I F; Wells, J A; Holmes, H E; Ismail, O; Richardson, S; Alexander, D C; Collins, E C; Fisher, E M; Johnson, R; Schwarz, A J; Ahmed, Z; O'Neill, M J; Murray, T K; Zhang, H; Lythgoe, M F
Citation:
Application of neurite orientation dispersion and density imaging (NODDI) to a tau pathology model of Alzheimer's disease. 2015, 125:739-744 Neuroimage
Publisher:
NeuroImage
Journal:
NeuroImage
Issue Date:
23-Oct-2015
URI:
http://hdl.handle.net/10147/583447
DOI:
10.1016/j.neuroimage.2015.10.043
PubMed ID:
26505297
Abstract:
Increased hyperphosphorylated tau and the formation of intracellular neurofibrillary tangles are associated with the loss of neurons and cognitive decline in Alzheimer's disease, and related neurodegenerative conditions. We applied two diffusion models, diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI), to in vivo diffusion magnetic resonance images (dMRI) of a mouse model of human tauopathy (rTg4510) at 8.5months of age. In grey matter regions with the highest degree of tau burden, microstructural indices provided by both NODDI and DTI discriminated the rTg4510 (TG) animals from wild type (WT) controls; however only the neurite density index (NDI) (the volume fraction that comprises axons or dendrites) from the NODDI model correlated with the histological measurements of the levels of hyperphosphorylated tau protein. Reductions in diffusion directionality were observed when implementing both models in the white matter region of the corpus callosum, with lower fractional anisotropy (DTI) and higher orientation dispersion (NODDI) observed in the TG animals. In comparison to DTI, histological measures of tau pathology were more closely correlated with NODDI parameters in this region. This in vivo dMRI study demonstrates that NODDI identifies potential tissue sources contributing to DTI indices and NODDI may provide greater specificity to pathology in Alzheimer's disease.
Item Type:
Article
Language:
en
Keywords:
ALZHEIMER'S DISEASE; NEUROLOGY
ISSN:
1095-9572

Full metadata record

DC FieldValue Language
dc.contributor.authorColgan, Nen
dc.contributor.authorSiow, Ben
dc.contributor.authorO'Callaghan, J Men
dc.contributor.authorHarrison, I Fen
dc.contributor.authorWells, J Aen
dc.contributor.authorHolmes, H Een
dc.contributor.authorIsmail, Oen
dc.contributor.authorRichardson, Sen
dc.contributor.authorAlexander, D Cen
dc.contributor.authorCollins, E Cen
dc.contributor.authorFisher, E Men
dc.contributor.authorJohnson, Ren
dc.contributor.authorSchwarz, A Jen
dc.contributor.authorAhmed, Zen
dc.contributor.authorO'Neill, M Jen
dc.contributor.authorMurray, T Ken
dc.contributor.authorZhang, Hen
dc.contributor.authorLythgoe, M Fen
dc.date.accessioned2015-12-09T10:40:02Zen
dc.date.available2015-12-09T10:40:02Zen
dc.date.issued2015-10-23en
dc.identifier.citationApplication of neurite orientation dispersion and density imaging (NODDI) to a tau pathology model of Alzheimer's disease. 2015, 125:739-744 Neuroimageen
dc.identifier.issn1095-9572en
dc.identifier.pmid26505297en
dc.identifier.doi10.1016/j.neuroimage.2015.10.043en
dc.identifier.urihttp://hdl.handle.net/10147/583447en
dc.description.abstractIncreased hyperphosphorylated tau and the formation of intracellular neurofibrillary tangles are associated with the loss of neurons and cognitive decline in Alzheimer's disease, and related neurodegenerative conditions. We applied two diffusion models, diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI), to in vivo diffusion magnetic resonance images (dMRI) of a mouse model of human tauopathy (rTg4510) at 8.5months of age. In grey matter regions with the highest degree of tau burden, microstructural indices provided by both NODDI and DTI discriminated the rTg4510 (TG) animals from wild type (WT) controls; however only the neurite density index (NDI) (the volume fraction that comprises axons or dendrites) from the NODDI model correlated with the histological measurements of the levels of hyperphosphorylated tau protein. Reductions in diffusion directionality were observed when implementing both models in the white matter region of the corpus callosum, with lower fractional anisotropy (DTI) and higher orientation dispersion (NODDI) observed in the TG animals. In comparison to DTI, histological measures of tau pathology were more closely correlated with NODDI parameters in this region. This in vivo dMRI study demonstrates that NODDI identifies potential tissue sources contributing to DTI indices and NODDI may provide greater specificity to pathology in Alzheimer's disease.en
dc.languageENGen
dc.language.isoenen
dc.publisherNeuroImageen
dc.rightsArchived with thanks to NeuroImageen
dc.subjectALZHEIMER'S DISEASEen
dc.subjectNEUROLOGYen
dc.titleApplication of neurite orientation dispersion and density imaging (NODDI) to a tau pathology model of Alzheimer's disease.en
dc.typeArticleen
dc.identifier.journalNeuroImageen
dc.description.fundingNo fundingen
dc.description.provinceConnachten
dc.description.peer-reviewpeer-reviewen

Related articles on PubMed

All Items in Lenus, The Irish Health Repository are protected by copyright, with all rights reserved, unless otherwise indicated.