A case of failed eradication of cystic fibrosis-related sinus colonisation by Pseudomonas aeruginosa.

Hdl Handle:
http://hdl.handle.net/10147/583445
Title:
A case of failed eradication of cystic fibrosis-related sinus colonisation by Pseudomonas aeruginosa.
Authors:
Linnane, Barry; Kearse, Linda; O' Connell, Nuala H; Fenton, John; Kiernan, Miranda G; Dunne, Colum P
Citation:
A case of failed eradication of cystic fibrosis-related sinus colonisation by Pseudomonas aeruginosa. 2015, 15:114 BMC Pulm Med
Publisher:
BMC pulmonary medicine
Journal:
BMC pulmonary medicine
Issue Date:
Oct-2015
URI:
http://hdl.handle.net/10147/583445
DOI:
10.1186/s12890-015-0113-0
PubMed ID:
26445233
Abstract:
Pseudomonas aeruginosa is a pathogen associated with cystic fibrosis that has potential to decrease lung function and cause respiratory failure. Paranasal sinuses are increasingly recognised as potential reservoirs for intermittent colonisation by P. aeruginosa. This case documents investigation and outcome of P. aeruginosa recurrence in a male paediatric patient over an eight year period.; A 12 year old Irish male paediatric cystic fibrosis patient experienced intermittent culturing of P. aeruginosa from the oropharyngeal region, indicating chronic infection of the sinuses despite absence of symptoms, retaining good lung function, and normal bronchoscopy and bronchoalveloar lavage. However, P. aeruginosa was isolated from a sinus wash-out and was identified as a unique strain of P. aeruginosa that was also cultured from cough swabs. Despite treatment, successful eradication from the paranasal sinuses was not achieved.; Few reports have addressed the paranasal sinuses as a reservoir for lung infection in cystic fibrosis patients despite increased recognition of the need to investigate this niche. In this case, attempts at eradication of P. aeruginosa present in paranasal sinuses including oral and nebulised antimicrobials proved unsuccessful. However, detection of P. aeruginosa in the paranasal sinuses instigated antimicrobial treatment which may have contributed to prevention of migration to the lower airways. Our outcome provides additional insight and may indicate utility of nasal lavage or nasal endoscopy in paediatric cystic fibrosis patients' annual review clinic visits.
Item Type:
Article
Language:
en
Keywords:
CYSTIC FIBROSIS; INFECTION CONTROL; PULMONARY DISORDER
ISSN:
1471-2466

Full metadata record

DC FieldValue Language
dc.contributor.authorLinnane, Barryen
dc.contributor.authorKearse, Lindaen
dc.contributor.authorO' Connell, Nuala Hen
dc.contributor.authorFenton, Johnen
dc.contributor.authorKiernan, Miranda Gen
dc.contributor.authorDunne, Colum Pen
dc.date.accessioned2015-12-09T10:28:13Zen
dc.date.available2015-12-09T10:28:13Zen
dc.date.issued2015-10en
dc.identifier.citationA case of failed eradication of cystic fibrosis-related sinus colonisation by Pseudomonas aeruginosa. 2015, 15:114 BMC Pulm Meden
dc.identifier.issn1471-2466en
dc.identifier.pmid26445233en
dc.identifier.doi10.1186/s12890-015-0113-0en
dc.identifier.urihttp://hdl.handle.net/10147/583445en
dc.description.abstractPseudomonas aeruginosa is a pathogen associated with cystic fibrosis that has potential to decrease lung function and cause respiratory failure. Paranasal sinuses are increasingly recognised as potential reservoirs for intermittent colonisation by P. aeruginosa. This case documents investigation and outcome of P. aeruginosa recurrence in a male paediatric patient over an eight year period.en
dc.description.abstractA 12 year old Irish male paediatric cystic fibrosis patient experienced intermittent culturing of P. aeruginosa from the oropharyngeal region, indicating chronic infection of the sinuses despite absence of symptoms, retaining good lung function, and normal bronchoscopy and bronchoalveloar lavage. However, P. aeruginosa was isolated from a sinus wash-out and was identified as a unique strain of P. aeruginosa that was also cultured from cough swabs. Despite treatment, successful eradication from the paranasal sinuses was not achieved.en
dc.description.abstractFew reports have addressed the paranasal sinuses as a reservoir for lung infection in cystic fibrosis patients despite increased recognition of the need to investigate this niche. In this case, attempts at eradication of P. aeruginosa present in paranasal sinuses including oral and nebulised antimicrobials proved unsuccessful. However, detection of P. aeruginosa in the paranasal sinuses instigated antimicrobial treatment which may have contributed to prevention of migration to the lower airways. Our outcome provides additional insight and may indicate utility of nasal lavage or nasal endoscopy in paediatric cystic fibrosis patients' annual review clinic visits.en
dc.language.isoenen
dc.publisherBMC pulmonary medicineen
dc.rightsArchived with thanks to BMC pulmonary medicineen
dc.subjectCYSTIC FIBROSISen
dc.subjectINFECTION CONTROLen
dc.subjectPULMONARY DISORDERen
dc.titleA case of failed eradication of cystic fibrosis-related sinus colonisation by Pseudomonas aeruginosa.en
dc.typeArticleen
dc.identifier.journalBMC pulmonary medicineen

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