A prolonged outbreak of invasive meningococcal disease in an extended Irish Traveller family across three Health Service Executive (HSE) areas in Ireland, 2010 to 2013

Hdl Handle:
http://hdl.handle.net/10147/583441
Title:
A prolonged outbreak of invasive meningococcal disease in an extended Irish Traveller family across three Health Service Executive (HSE) areas in Ireland, 2010 to 2013
Authors:
Health Service Executive (HSE); O’Connor, L; Ward, M; Bennett, D; Mulhall, R; O’Lorcain, P; Cunney, R; Cunney, R; McDermott, R; Neville, E; Heslin, J; FitzGerald, R; Meyler, K; Conlon, M; Clarke, A; Corcoran, B; Fitzpatrick, G; O’Connor, B; Flanagan, P; O’Flanagan, D; Cotter, S
Affiliation:
Health Service Executive (HSE)
Citation:
A prolonged outbreak of invasive meningococcal disease in an extended Irish Traveller family across three Health Service Executive (HSE) areas in Ireland, 2010 to 2013 2015, 20 (21):21139 Eurosurveillance
Publisher:
Eurosurveillance
Journal:
Eurosurveillance
Issue Date:
28-May-2015
URI:
http://hdl.handle.net/10147/583441
DOI:
10.2807/1560-7917.ES2015.20.21.21139
Additional Links:
http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=21139
Item Type:
Article
Language:
en
Description:
Between March 2010 and November 2013 eight laboratory-confirmed cases of serogroup B, invasive meningococcal disease (IMD) were identified in an extended Irish Traveller family across three Health Service Executive (HSE) areas of Ireland. Cases were aged between 5 and 46 months, and were either a cousin or sibling of another case. All eight cases survived. Chemoprophylaxis was given to relevant nuclear family members and close contacts on each occasion, but failed to prevent further cases. Neisseria meningitidis isolates from six cases were highly related, belonging to the ST-41/44 clonal complex, and shared the porA designation 7–2,4. In November 2013, the outbreak control team recommended that directly observed ciprofloxacin chemoprophylaxis be administered simultaneously to the extended family, and that the four component meningococcal B (4CMenB) vaccine be administered to family members aged 2 months to 23 years inclusive and relevant close contacts of the eighth case. Subsequently these recommendations were implemented at three regional clinics. Additionally pharyngeal swabs (n=112) were collected to assess carriage rates of N. meningitidis in this extended family. Pharyngeal carriage of N. meningitidis was detected in 15 (13%) family members. From the epidemiological investigation and carriage study overcrowding was the most likely risk factor identified in this outbreak. To date, the combination of directly observed ciprofloxacin chemoprophylaxis and use of 4CMenB vaccine have controlled the outbreak with no further cases diagnosed.
Keywords:
INFECTION CONTROL; IMMUNISATION; MENINGITIS; TRAVELLERS AND GYPSIES
Local subject classification:
INFECTIOUS DISEASES; PUBLIC HEALTH DEPARTMENT; HEALTH PROTECTION; HEALTH SERVICE PLANNING; HEALTH STATUS; PUBLIC INFORMATION
ISSN:
1560-7917

Full metadata record

DC FieldValue Language
dc.contributor.authorHealth Service Executive (HSE)en
dc.contributor.authorO’Connor, Len
dc.contributor.authorWard, Men
dc.contributor.authorBennett, Den
dc.contributor.authorMulhall, Ren
dc.contributor.authorO’Lorcain, Pen
dc.contributor.authorCunney, Ren
dc.contributor.authorCunney, Ren
dc.contributor.authorMcDermott, Ren
dc.contributor.authorNeville, Een
dc.contributor.authorHeslin, Jen
dc.contributor.authorFitzGerald, Ren
dc.contributor.authorMeyler, Ken
dc.contributor.authorConlon, Men
dc.contributor.authorClarke, Aen
dc.contributor.authorCorcoran, Ben
dc.contributor.authorFitzpatrick, Gen
dc.contributor.authorO’Connor, Ben
dc.contributor.authorFlanagan, Pen
dc.contributor.authorO’Flanagan, Den
dc.contributor.authorCotter, Sen
dc.date.accessioned2015-12-09T10:15:50Zen
dc.date.available2015-12-09T10:15:50Zen
dc.date.issued2015-05-28en
dc.identifier.citationA prolonged outbreak of invasive meningococcal disease in an extended Irish Traveller family across three Health Service Executive (HSE) areas in Ireland, 2010 to 2013 2015, 20 (21):21139 Eurosurveillanceen
dc.identifier.issn1560-7917en
dc.identifier.doi10.2807/1560-7917.ES2015.20.21.21139en
dc.identifier.urihttp://hdl.handle.net/10147/583441en
dc.descriptionBetween March 2010 and November 2013 eight laboratory-confirmed cases of serogroup B, invasive meningococcal disease (IMD) were identified in an extended Irish Traveller family across three Health Service Executive (HSE) areas of Ireland. Cases were aged between 5 and 46 months, and were either a cousin or sibling of another case. All eight cases survived. Chemoprophylaxis was given to relevant nuclear family members and close contacts on each occasion, but failed to prevent further cases. Neisseria meningitidis isolates from six cases were highly related, belonging to the ST-41/44 clonal complex, and shared the porA designation 7–2,4. In November 2013, the outbreak control team recommended that directly observed ciprofloxacin chemoprophylaxis be administered simultaneously to the extended family, and that the four component meningococcal B (4CMenB) vaccine be administered to family members aged 2 months to 23 years inclusive and relevant close contacts of the eighth case. Subsequently these recommendations were implemented at three regional clinics. Additionally pharyngeal swabs (n=112) were collected to assess carriage rates of N. meningitidis in this extended family. Pharyngeal carriage of N. meningitidis was detected in 15 (13%) family members. From the epidemiological investigation and carriage study overcrowding was the most likely risk factor identified in this outbreak. To date, the combination of directly observed ciprofloxacin chemoprophylaxis and use of 4CMenB vaccine have controlled the outbreak with no further cases diagnosed.en
dc.language.isoenen
dc.publisherEurosurveillanceen
dc.relation.urlhttp://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=21139en
dc.rightsArchived with thanks to Eurosurveillanceen
dc.subjectINFECTION CONTROLen
dc.subjectIMMUNISATIONen
dc.subjectMENINGITISen
dc.subjectTRAVELLERS AND GYPSIESen
dc.subject.otherINFECTIOUS DISEASESen
dc.subject.otherPUBLIC HEALTH DEPARTMENTen
dc.subject.otherHEALTH PROTECTIONen
dc.subject.otherHEALTH SERVICE PLANNINGen
dc.subject.otherHEALTH STATUSen
dc.subject.otherPUBLIC INFORMATIONen
dc.titleA prolonged outbreak of invasive meningococcal disease in an extended Irish Traveller family across three Health Service Executive (HSE) areas in Ireland, 2010 to 2013en
dc.typeArticleen
dc.contributor.departmentHealth Service Executive (HSE)en
dc.identifier.journalEurosurveillanceen
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