A case of failed eradication of cystic fibrosis-related sinus colonisation by Pseudomonas aeruginosa

Hdl Handle:
http://hdl.handle.net/10147/579430
Title:
A case of failed eradication of cystic fibrosis-related sinus colonisation by Pseudomonas aeruginosa
Authors:
Linnane, Barry; Kearse, Linda; O’ Connell, Nuala H; Fenton, John; Kiernan, Miranda G; Dunne, Colum P
Citation:
BMC Pulmonary Medicine. 2015 Oct 06;15(1):114
Issue Date:
6-Oct-2015
URI:
http://dx.doi.org/10.1186/s12890-015-0113-0; http://hdl.handle.net/10147/579430
Abstract:
Abstract Background Pseudomonas aeruginosa is a pathogen associated with cystic fibrosis that has potential to decrease lung function and cause respiratory failure. Paranasal sinuses are increasingly recognised as potential reservoirs for intermittent colonisation by P. aeruginosa. This case documents investigation and outcome of P. aeruginosa recurrence in a male paediatric patient over an eight year period. Case presentation A 12 year old Irish male paediatric cystic fibrosis patient experienced intermittent culturing of P. aeruginosa from the oropharyngeal region, indicating chronic infection of the sinuses despite absence of symptoms, retaining good lung function, and normal bronchoscopy and bronchoalveloar lavage. However, P. aeruginosa was isolated from a sinus wash-out and was identified as a unique strain of P. aeruginosa that was also cultured from cough swabs. Despite treatment, successful eradication from the paranasal sinuses was not achieved. Conclusions Few reports have addressed the paranasal sinuses as a reservoir for lung infection in cystic fibrosis patients despite increased recognition of the need to investigate this niche. In this case, attempts at eradication of P. aeruginosa present in paranasal sinuses including oral and nebulised antimicrobials proved unsuccessful. However, detection of P. aeruginosa in the paranasal sinuses instigated antimicrobial treatment which may have contributed to prevention of migration to the lower airways. Our outcome provides additional insight and may indicate utility of nasal lavage or nasal endoscopy in paediatric cystic fibrosis patients’ annual review clinic visits.
Language:
en
Keywords:
CYSTIC FIBROSIS; LUNG DISEASE

Full metadata record

DC FieldValue Language
dc.contributor.authorLinnane, Barryen
dc.contributor.authorKearse, Lindaen
dc.contributor.authorO’ Connell, Nuala Hen
dc.contributor.authorFenton, Johnen
dc.contributor.authorKiernan, Miranda Gen
dc.contributor.authorDunne, Colum Pen
dc.date.accessioned2015-10-07T08:58:54Zen
dc.date.available2015-10-07T08:58:54Zen
dc.date.issued2015-10-06en
dc.identifier.citationBMC Pulmonary Medicine. 2015 Oct 06;15(1):114en
dc.identifier.urihttp://dx.doi.org/10.1186/s12890-015-0113-0en
dc.identifier.urihttp://hdl.handle.net/10147/579430en
dc.description.abstractAbstract Background Pseudomonas aeruginosa is a pathogen associated with cystic fibrosis that has potential to decrease lung function and cause respiratory failure. Paranasal sinuses are increasingly recognised as potential reservoirs for intermittent colonisation by P. aeruginosa. This case documents investigation and outcome of P. aeruginosa recurrence in a male paediatric patient over an eight year period. Case presentation A 12 year old Irish male paediatric cystic fibrosis patient experienced intermittent culturing of P. aeruginosa from the oropharyngeal region, indicating chronic infection of the sinuses despite absence of symptoms, retaining good lung function, and normal bronchoscopy and bronchoalveloar lavage. However, P. aeruginosa was isolated from a sinus wash-out and was identified as a unique strain of P. aeruginosa that was also cultured from cough swabs. Despite treatment, successful eradication from the paranasal sinuses was not achieved. Conclusions Few reports have addressed the paranasal sinuses as a reservoir for lung infection in cystic fibrosis patients despite increased recognition of the need to investigate this niche. In this case, attempts at eradication of P. aeruginosa present in paranasal sinuses including oral and nebulised antimicrobials proved unsuccessful. However, detection of P. aeruginosa in the paranasal sinuses instigated antimicrobial treatment which may have contributed to prevention of migration to the lower airways. Our outcome provides additional insight and may indicate utility of nasal lavage or nasal endoscopy in paediatric cystic fibrosis patients’ annual review clinic visits.en
dc.language.isoenen
dc.subjectCYSTIC FIBROSISen
dc.subjectLUNG DISEASEen
dc.titleA case of failed eradication of cystic fibrosis-related sinus colonisation by Pseudomonas aeruginosaen
dc.language.rfc3066enen
dc.rights.holderLinnane et al.en
dc.date.updated2015-10-06T16:03:44Zen
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