Postnatal MRI brain in infants treated for Twin–Twin Transfusion Syndrome

Hdl Handle:
http://hdl.handle.net/10147/578544
Title:
Postnatal MRI brain in infants treated for Twin–Twin Transfusion Syndrome
Authors:
Boyle, M; Lyons, A; Ryan, S; Malone, F; Foran, A; Ryan, S
Publisher:
Irish Medical Journal
Journal:
Irish Medical Journal
Issue Date:
Sep-2015
URI:
http://hdl.handle.net/10147/578544
Abstract:
Untreated twin-twin transfusion syndrome (TTTS) is associated with significant mortality and neurological impairment. Fetoscopic laser surgery (FLS) is the treatment of choice. We sought to assess intracranial abnormalities in TTTS twins following treatment. In this prospective, blinded study MRI scans were performed on 3 groups; (1) monochorionic diamniotic (MCDA) twins with TTTS who had undergone FLS (n=10), (2) MCDA twins without TTTS (n=8) and (3) dichorionic twins (n=8). Scans were scored as either normal or abnormal. The primary outcome was a composite of abnormal MRI brain or intrauterine fetal demise. The primary outcome occurred in 6/10 (60%) of the TTTS group versus 3/8 (37.5%) in the MCDA group. The primary outcome was significantly different across all study groups [p = 0.029; X² = 7.112]. We found that twins treated for TTTS are more likely to have abnormalities on MRI brain at term than other twin groups. This group merits term-corrected MRI as part of their postnatal assessment
Item Type:
Article
Language:
en
Keywords:
MAGNETIC RESONANCE IMAGING; NEONATAL MEDICINE; PAEDIATRICS

Full metadata record

DC FieldValue Language
dc.contributor.authorBoyle, Men
dc.contributor.authorLyons, Aen
dc.contributor.authorRyan, Sen
dc.contributor.authorMalone, Fen
dc.contributor.authorForan, Aen
dc.contributor.authorRyan, Sen
dc.date.accessioned2015-09-21T15:04:43Zen
dc.date.available2015-09-21T15:04:43Zen
dc.date.issued2015-09en
dc.identifier.urihttp://hdl.handle.net/10147/578544en
dc.description.abstractUntreated twin-twin transfusion syndrome (TTTS) is associated with significant mortality and neurological impairment. Fetoscopic laser surgery (FLS) is the treatment of choice. We sought to assess intracranial abnormalities in TTTS twins following treatment. In this prospective, blinded study MRI scans were performed on 3 groups; (1) monochorionic diamniotic (MCDA) twins with TTTS who had undergone FLS (n=10), (2) MCDA twins without TTTS (n=8) and (3) dichorionic twins (n=8). Scans were scored as either normal or abnormal. The primary outcome was a composite of abnormal MRI brain or intrauterine fetal demise. The primary outcome occurred in 6/10 (60%) of the TTTS group versus 3/8 (37.5%) in the MCDA group. The primary outcome was significantly different across all study groups [p = 0.029; X² = 7.112]. We found that twins treated for TTTS are more likely to have abnormalities on MRI brain at term than other twin groups. This group merits term-corrected MRI as part of their postnatal assessmenten
dc.language.isoenen
dc.publisherIrish Medical Journalen
dc.subjectMAGNETIC RESONANCE IMAGINGen
dc.subjectNEONATAL MEDICINEen
dc.subjectPAEDIATRICSen
dc.titlePostnatal MRI brain in infants treated for Twin–Twin Transfusion Syndromeen
dc.typeArticleen
dc.identifier.journalIrish Medical Journalen
dc.description.fundingNo fundingen
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen
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