Hdl Handle:
http://hdl.handle.net/10147/575036
Title:
The way forward for the refractory asthmatic
Authors:
Kooblall, M; Moloney, E; Lane, SJ
Publisher:
Irish Medical Journal
Journal:
Irish Medical Journal
Issue Date:
Jul-2015
URI:
http://hdl.handle.net/10147/575036
Abstract:
Ireland has the fourth highest prevalence of asthma in the world. 7.1% of 18+ population and 18.9% of 13-15 year olds have asthma. 38.5% of 13-15 year olds reported wheezing. More than 1 person a week dies from asthma and 29% of asthma patients miss school or work. 1 Despite very safe and effective treatment 5-10% of patients with bronchial asthma do not respond well to their treatment. This group of patients are labelled as refractory asthmatics. Besides compliance, presence of psychogenic and trigger factors and comorbid illness, steroid insensitiveness or resistance may play a significant role in the poorly controlled/responding asthmatics. Type I Steroid resistance is due to lack of binding affinity of steroids to glucocorticoid receptors and may respond to higher doses of steroids while type II steroid resistance is because of reduced number of cells with glucocorticoid receptors, which is very rare and do not respond to even higher doses of systemic steroids and these cases require alternative/novel therapies. 2
Item Type:
Article
Language:
en
Keywords:
ASTHMA

Full metadata record

DC FieldValue Language
dc.contributor.authorKooblall, Men
dc.contributor.authorMoloney, Een
dc.contributor.authorLane, SJen
dc.date.accessioned2015-08-18T11:41:42Zen
dc.date.available2015-08-18T11:41:42Zen
dc.date.issued2015-07en
dc.identifier.urihttp://hdl.handle.net/10147/575036en
dc.description.abstractIreland has the fourth highest prevalence of asthma in the world. 7.1% of 18+ population and 18.9% of 13-15 year olds have asthma. 38.5% of 13-15 year olds reported wheezing. More than 1 person a week dies from asthma and 29% of asthma patients miss school or work. 1 Despite very safe and effective treatment 5-10% of patients with bronchial asthma do not respond well to their treatment. This group of patients are labelled as refractory asthmatics. Besides compliance, presence of psychogenic and trigger factors and comorbid illness, steroid insensitiveness or resistance may play a significant role in the poorly controlled/responding asthmatics. Type I Steroid resistance is due to lack of binding affinity of steroids to glucocorticoid receptors and may respond to higher doses of steroids while type II steroid resistance is because of reduced number of cells with glucocorticoid receptors, which is very rare and do not respond to even higher doses of systemic steroids and these cases require alternative/novel therapies. 2en
dc.language.isoenen
dc.publisherIrish Medical Journalen
dc.subjectASTHMAen
dc.titleThe way forward for the refractory asthmaticen
dc.typeArticleen
dc.identifier.journalIrish Medical Journalen
dc.description.fundingNo fundingen
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen
All Items in Lenus, The Irish Health Repository are protected by copyright, with all rights reserved, unless otherwise indicated.