A rare case of BRCA2-associated breast cancer in pregnancy

Hdl Handle:
http://hdl.handle.net/10147/575013
Title:
A rare case of BRCA2-associated breast cancer in pregnancy
Authors:
Leidhin, C N; Heeney, A; Connolly, C; Swan, N; Foster, A; Geraghty, J
Publisher:
Irish Medical Journal
Journal:
Irish Medical Journal
Issue Date:
Jul-2015
URI:
http://hdl.handle.net/10147/575013
Abstract:
A 30-year old woman was referred to our department with symptomatic breast cancer at 35 weeks gestation. Genetic testing revealed a pathogenic BRCA2 mutation. Labour was induced at 38 weeks. Mastectomy and axillary clearance were performed with a view to adjuvant chemotherapy, radiation and hormonal therapy. Multidisciplinary involvement is crucial for management of BRCA-associated breast cancer, especially in the context of pregnancy. Bilateral mastectomy may be indicated given the increased risk of ipsilateral and contralateral breast cancers. Tamoxifen may lower contralateral breast cancer risk in those in whom risk-reducing surgery is not performed.
Item Type:
Article
Language:
en
Keywords:
BREAST CANCER; PREGNANCY

Full metadata record

DC FieldValue Language
dc.contributor.authorLeidhin, C Nen
dc.contributor.authorHeeney, Aen
dc.contributor.authorConnolly, Cen
dc.contributor.authorSwan, Nen
dc.contributor.authorFoster, Aen
dc.contributor.authorGeraghty, Jen
dc.date.accessioned2015-08-18T11:23:10Zen
dc.date.available2015-08-18T11:23:10Zen
dc.date.issued2015-07en
dc.identifier.urihttp://hdl.handle.net/10147/575013en
dc.description.abstractA 30-year old woman was referred to our department with symptomatic breast cancer at 35 weeks gestation. Genetic testing revealed a pathogenic BRCA2 mutation. Labour was induced at 38 weeks. Mastectomy and axillary clearance were performed with a view to adjuvant chemotherapy, radiation and hormonal therapy. Multidisciplinary involvement is crucial for management of BRCA-associated breast cancer, especially in the context of pregnancy. Bilateral mastectomy may be indicated given the increased risk of ipsilateral and contralateral breast cancers. Tamoxifen may lower contralateral breast cancer risk in those in whom risk-reducing surgery is not performed.en
dc.language.isoenen
dc.publisherIrish Medical Journalen
dc.subjectBREAST CANCERen
dc.subjectPREGNANCYen
dc.titleA rare case of BRCA2-associated breast cancer in pregnancyen
dc.typeArticleen
dc.identifier.journalIrish Medical Journalen
dc.description.fundingNo fundingen
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen
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