Changing paradigms for oropharynx cancer: swinging of pendulum back towards surgery

Hdl Handle:
http://hdl.handle.net/10147/575005
Title:
Changing paradigms for oropharynx cancer: swinging of pendulum back towards surgery
Authors:
Sheahan, P
Publisher:
Irish Medical Journal
Journal:
Irish Medical Journal
Issue Date:
Jul-2015
URI:
http://hdl.handle.net/10147/575005
Abstract:
The oropharynx, extending from the soft palate to the level of the epiglottis, and containing the palatine tonsils and base of tongue (BOT), is a common site for Head and Neck cancer. Squamous cell carcinoma (SCC) comprises the overwhelming majority of cases. Traditional aetiological factors for oropharynx SCC (OPSCC) are smoking and alcohol consumption. In recent years, human papilloma virus (HPV) type 16 has emerged as the major cause of an ever increasing number of cases 1 . Over the last two decades, there has been a dramatic surge in the incidence of OPSCC. Figures obtained by the Irish National Cancer Registry show an increase from 50 cases per year in 1994 to over 100 cases per year in 2012. This recent rise in OPSCC incidence is almost exclusively related to an increase in HPV related cancers. In the United States, between 1988 and 2004, HPV related OPSCC showed a 225% increase, while HPV-negative OP SCC showed a 50% decline, attributed to decreased prevalence of smoking 1 .
Item Type:
Article
Language:
en
Keywords:
CANCER; SURGERY

Full metadata record

DC FieldValue Language
dc.contributor.authorSheahan, Pen
dc.date.accessioned2015-08-18T10:56:41Zen
dc.date.available2015-08-18T10:56:41Zen
dc.date.issued2015-07en
dc.identifier.urihttp://hdl.handle.net/10147/575005en
dc.description.abstractThe oropharynx, extending from the soft palate to the level of the epiglottis, and containing the palatine tonsils and base of tongue (BOT), is a common site for Head and Neck cancer. Squamous cell carcinoma (SCC) comprises the overwhelming majority of cases. Traditional aetiological factors for oropharynx SCC (OPSCC) are smoking and alcohol consumption. In recent years, human papilloma virus (HPV) type 16 has emerged as the major cause of an ever increasing number of cases 1 . Over the last two decades, there has been a dramatic surge in the incidence of OPSCC. Figures obtained by the Irish National Cancer Registry show an increase from 50 cases per year in 1994 to over 100 cases per year in 2012. This recent rise in OPSCC incidence is almost exclusively related to an increase in HPV related cancers. In the United States, between 1988 and 2004, HPV related OPSCC showed a 225% increase, while HPV-negative OP SCC showed a 50% decline, attributed to decreased prevalence of smoking 1 .en
dc.language.isoenen
dc.publisherIrish Medical Journalen
dc.subjectCANCERen
dc.subjectSURGERYen
dc.titleChanging paradigms for oropharynx cancer: swinging of pendulum back towards surgeryen
dc.typeArticleen
dc.identifier.journalIrish Medical Journalen
dc.description.fundingNo fundingen
dc.description.provinceMunsteren
dc.description.peer-reviewpeer-reviewen
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