Cylindroma of the breast: a case report and review of the literature

Hdl Handle:
http://hdl.handle.net/10147/574999
Title:
Cylindroma of the breast: a case report and review of the literature
Authors:
Mahmoud, Amr; Hill, David H; O'Sullivan, Martin J; Bennett, Michael W
Citation:
Diagnostic Pathology. 2009 Sep 02;4(1):30
Issue Date:
2-Sep-2009
URI:
http://dx.doi.org/10.1186/1746-1596-4-30; http://hdl.handle.net/10147/574999
Abstract:
Abstract Cylindroma of the breast is a very rare lesion which is morphological and immunophenotypically identical to benign dermal cylindroma. We report a breast cylindroma in a previously healthy 62 year old female detected through a national breast screening program. The patient had no significant family or past medical history, and specifically no history of breast or skin diseases. The tumor consisted of well circumscribed islands of epithelial cells surrounded by a dense membrane material, and focally containing hyaline globules. At low power the islands of tumour cells formed a "jig-saw" pattern, which is typical of cylindroma, but was present within normal breast parenchyma and no had direct connection with the overlying skin. Two distinct cell populations, smaller peripheral basaloid cells and larger central cells with vesicular chromatin, were highlighted by immunohistochemistry for p63 and cytokeratin-7 respectively. Immunohistochemistry for ER, PR, and Her2/neu was negative in tumour cells. We discuss the nine previously reported cases and the distinction of breast cylindroma from adenoid cystic carcinoma, the main differential diagnosis.
Language:
en
Keywords:
BREAST CANCER; SCREENING

Full metadata record

DC FieldValue Language
dc.contributor.authorMahmoud, Amren
dc.contributor.authorHill, David Hen
dc.contributor.authorO'Sullivan, Martin Jen
dc.contributor.authorBennett, Michael Wen
dc.date.accessioned2015-08-18T09:58:56Zen
dc.date.available2015-08-18T09:58:56Zen
dc.date.issued2009-09-02en
dc.identifier.citationDiagnostic Pathology. 2009 Sep 02;4(1):30en
dc.identifier.urihttp://dx.doi.org/10.1186/1746-1596-4-30en
dc.identifier.urihttp://hdl.handle.net/10147/574999en
dc.description.abstractAbstract Cylindroma of the breast is a very rare lesion which is morphological and immunophenotypically identical to benign dermal cylindroma. We report a breast cylindroma in a previously healthy 62 year old female detected through a national breast screening program. The patient had no significant family or past medical history, and specifically no history of breast or skin diseases. The tumor consisted of well circumscribed islands of epithelial cells surrounded by a dense membrane material, and focally containing hyaline globules. At low power the islands of tumour cells formed a "jig-saw" pattern, which is typical of cylindroma, but was present within normal breast parenchyma and no had direct connection with the overlying skin. Two distinct cell populations, smaller peripheral basaloid cells and larger central cells with vesicular chromatin, were highlighted by immunohistochemistry for p63 and cytokeratin-7 respectively. Immunohistochemistry for ER, PR, and Her2/neu was negative in tumour cells. We discuss the nine previously reported cases and the distinction of breast cylindroma from adenoid cystic carcinoma, the main differential diagnosis.en
dc.language.isoenen
dc.subjectBREAST CANCERen
dc.subjectSCREENINGen
dc.titleCylindroma of the breast: a case report and review of the literatureen
dc.language.rfc3066enen
dc.rights.holderMahmoud et al.en
dc.date.updated2015-08-14T13:18:36Zen
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