Magnetic resonance myocardial perfusion imaging in the diagnosis of functionally significant obstructive coronary artery disease: a systematic review protocol

Hdl Handle:
http://hdl.handle.net/10147/574918
Title:
Magnetic resonance myocardial perfusion imaging in the diagnosis of functionally significant obstructive coronary artery disease: a systematic review protocol
Authors:
Pharithi, Rebabonye B; Meela, Martinus; Kropmans, Thomas; Ward, Frank; Conway, Michael; Newell, Michael
Citation:
Systematic Reviews. 2014 May 26;3(1):53
Issue Date:
26-May-2014
URI:
http://dx.doi.org/10.1186/2046-4053-3-53; http://hdl.handle.net/10147/574918
Abstract:
Abstract Background Cardiac magnetic resonance (CMR) myocardial perfusion imaging has been suggested as a non-invasive alternative to pressure wire guided fractional flow reserve (FFR) in detecting haemodynamically significant obstructive coronary artery disease (CAD). The objective of this systematic review is to determine the diagnostic accuracy of CMR and to compare it to FFR. Methods/design A systematic review of diagnostic test accuracy of CMR and FFR will be conducted. Relevant English-language articles published before November 2013 in Medline, PubMed, EMBASE, Google scholar, Scopus and Cochrane databases will be identified. Relevant referenced articles from those selected will also be analysed. Articles describing diagnostic studies that compared CMR to FFR in patients with known or suspected coronary artery disease will be included. Two investigators will independently screen, assess quality and extract data from the selected articles. The Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) tool will be used to assess methodological quality. STATA 13 (the xtmelogit command) software will be used to calculate bivariate random effects models and estimate pooled sensitivity and specificity with 95% confidence intervals. Forests plots and summary receiver operating characteristics curves will also be generated. Sub-group pooled analyses using image quality of CMR (in terms of magnetic flux density - Tesla) and basis of analyses (coronary arterial territory vs. patients basis) at different FFR cutoffs (≤0.75 and ≤0.8) will also be performed. Discussion This systematic review will help to determine if CMR is an adequate alternative to FFR in the diagnosis of significant and obstructive CAD. We will also be able to assess diagnostic accuracy of specific types of CMR scan at different FFR cutoffs. Systematic review registration This systematic review had been registered at PROSPERO and the registration number is CRD42013006180.
Language:
en
Keywords:
CORONARY ARTERY DISEASE; MAGNETIC RESONANCE IMAGING

Full metadata record

DC FieldValue Language
dc.contributor.authorPharithi, Rebabonye Ben
dc.contributor.authorMeela, Martinusen
dc.contributor.authorKropmans, Thomasen
dc.contributor.authorWard, Franken
dc.contributor.authorConway, Michaelen
dc.contributor.authorNewell, Michaelen
dc.date.accessioned2015-08-17T14:51:48Zen
dc.date.available2015-08-17T14:51:48Zen
dc.date.issued2014-05-26en
dc.identifier.citationSystematic Reviews. 2014 May 26;3(1):53en
dc.identifier.urihttp://dx.doi.org/10.1186/2046-4053-3-53en
dc.identifier.urihttp://hdl.handle.net/10147/574918en
dc.description.abstractAbstract Background Cardiac magnetic resonance (CMR) myocardial perfusion imaging has been suggested as a non-invasive alternative to pressure wire guided fractional flow reserve (FFR) in detecting haemodynamically significant obstructive coronary artery disease (CAD). The objective of this systematic review is to determine the diagnostic accuracy of CMR and to compare it to FFR. Methods/design A systematic review of diagnostic test accuracy of CMR and FFR will be conducted. Relevant English-language articles published before November 2013 in Medline, PubMed, EMBASE, Google scholar, Scopus and Cochrane databases will be identified. Relevant referenced articles from those selected will also be analysed. Articles describing diagnostic studies that compared CMR to FFR in patients with known or suspected coronary artery disease will be included. Two investigators will independently screen, assess quality and extract data from the selected articles. The Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) tool will be used to assess methodological quality. STATA 13 (the xtmelogit command) software will be used to calculate bivariate random effects models and estimate pooled sensitivity and specificity with 95% confidence intervals. Forests plots and summary receiver operating characteristics curves will also be generated. Sub-group pooled analyses using image quality of CMR (in terms of magnetic flux density - Tesla) and basis of analyses (coronary arterial territory vs. patients basis) at different FFR cutoffs (≤0.75 and ≤0.8) will also be performed. Discussion This systematic review will help to determine if CMR is an adequate alternative to FFR in the diagnosis of significant and obstructive CAD. We will also be able to assess diagnostic accuracy of specific types of CMR scan at different FFR cutoffs. Systematic review registration This systematic review had been registered at PROSPERO and the registration number is CRD42013006180.en
dc.language.isoenen
dc.subjectCORONARY ARTERY DISEASEen
dc.subjectMAGNETIC RESONANCE IMAGINGen
dc.titleMagnetic resonance myocardial perfusion imaging in the diagnosis of functionally significant obstructive coronary artery disease: a systematic review protocolen
dc.language.rfc3066enen
dc.rights.holderPharithi et al.; licensee BioMed Central Ltd.en
dc.date.updated2015-08-14T13:19:37Zen
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