The effect of menopause and hysterectomy on systemic vascular endothelial growth factor in women undergoing surgery for breast cancer

Hdl Handle:
http://hdl.handle.net/10147/574404
Title:
The effect of menopause and hysterectomy on systemic vascular endothelial growth factor in women undergoing surgery for breast cancer
Authors:
Lowery, Aoife J; Sweeney, Karl J; Molloy, Alan P; Hennessy, Emer; Curran, Catherine; Kerin, Michael J
Citation:
BMC Cancer. 2008 Sep 30;8(1):279
Issue Date:
30-Sep-2008
URI:
http://dx.doi.org/10.1186/1471-2407-8-279; http://hdl.handle.net/10147/574404
Abstract:
Abstract Background Vascular endothelial growth factor (VEGF) is a potent angiogenic cytokine produced physiologically by the uterus. Pathological secretion by tumours promotes growth and metastasis. High circulating VEGF levels potentially have a deleterious effect on breast cancer by promoting disease progression. The aims of this study were to investigate circulating VEGF levels in breast cancer patients and assess the effect of menopause or hysterectomy on systemic VEGF. Methods Patients undergoing primary surgery for breast cancer and controls matched for age, menopausal and hysterectomy status were prospectively recruited. Serum VEGF, FSH, LH, estrogen, progesterone and platelet levels were measured. Serum VEGF was corrected for platelet load (sVEGFp) to provide a biologically relevant measurement of circulating VEGF. SVEGFp levels were analyzed with respect to tumor characteristics, menopausal status and hysterectomy status. Results Two hundred women were included in the study; 89 breast cancer patients and 111 controls. SVEGFp levels were significantly higher in breast cancer patients compared to controls (p = 0.0001), but were not associated with clinico-pathological tumor characteristics. Systemic VEGF levels reduced significantly in the breast cancer patients following tumor excision (p = 0.018). The highest systemic VEGF levels were observed in postmenopausal breast cancer patients. Postmenopausal women who had had a previous hysterectomy had significantly higher VEGF levels than those with an intact postmenopausal uterus (p = 0.001). Conclusion This study identifies an intact postmenopausal uterus as a potential means of reducing circulating levels of VEGF which could confer a protective effect against breast cancer metastatic potential.
Language:
en
Keywords:
BREAST CANCER; MENOPAUSE; HYSTERECTOMY

Full metadata record

DC FieldValue Language
dc.contributor.authorLowery, Aoife Jen
dc.contributor.authorSweeney, Karl Jen
dc.contributor.authorMolloy, Alan Pen
dc.contributor.authorHennessy, Emeren
dc.contributor.authorCurran, Catherineen
dc.contributor.authorKerin, Michael Jen
dc.date.accessioned2015-08-17T13:15:33Zen
dc.date.available2015-08-17T13:15:33Zen
dc.date.issued2008-09-30en
dc.identifier.citationBMC Cancer. 2008 Sep 30;8(1):279en
dc.identifier.urihttp://dx.doi.org/10.1186/1471-2407-8-279en
dc.identifier.urihttp://hdl.handle.net/10147/574404en
dc.description.abstractAbstract Background Vascular endothelial growth factor (VEGF) is a potent angiogenic cytokine produced physiologically by the uterus. Pathological secretion by tumours promotes growth and metastasis. High circulating VEGF levels potentially have a deleterious effect on breast cancer by promoting disease progression. The aims of this study were to investigate circulating VEGF levels in breast cancer patients and assess the effect of menopause or hysterectomy on systemic VEGF. Methods Patients undergoing primary surgery for breast cancer and controls matched for age, menopausal and hysterectomy status were prospectively recruited. Serum VEGF, FSH, LH, estrogen, progesterone and platelet levels were measured. Serum VEGF was corrected for platelet load (sVEGFp) to provide a biologically relevant measurement of circulating VEGF. SVEGFp levels were analyzed with respect to tumor characteristics, menopausal status and hysterectomy status. Results Two hundred women were included in the study; 89 breast cancer patients and 111 controls. SVEGFp levels were significantly higher in breast cancer patients compared to controls (p = 0.0001), but were not associated with clinico-pathological tumor characteristics. Systemic VEGF levels reduced significantly in the breast cancer patients following tumor excision (p = 0.018). The highest systemic VEGF levels were observed in postmenopausal breast cancer patients. Postmenopausal women who had had a previous hysterectomy had significantly higher VEGF levels than those with an intact postmenopausal uterus (p = 0.001). Conclusion This study identifies an intact postmenopausal uterus as a potential means of reducing circulating levels of VEGF which could confer a protective effect against breast cancer metastatic potential.en
dc.language.isoenen
dc.subjectBREAST CANCERen
dc.subjectMENOPAUSEen
dc.subjectHYSTERECTOMYen
dc.titleThe effect of menopause and hysterectomy on systemic vascular endothelial growth factor in women undergoing surgery for breast canceren
dc.language.rfc3066enen
dc.rights.holderLowery et al.en
dc.date.updated2015-08-14T13:24:12Zen
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