Authors
O'Donoghue, TMorris, D W
Fahey, C
Da Costa, A
Moore, S
Cummings, E
Leicht, G
Karch, S
Hoerold, D
Tropea, D
Foxe, J J
Gill, M
Corvin, A
Donohoe, G
Issue Date
2014-01Keywords
SCHIZOPHRENIAGENETICS
MeSH
AdultElectroencephalography
Endophenotypes
Event-Related Potentials, P300
Evoked Potentials, Auditory
Female
Genotype
Humans
Kruppel-Like Transcription Factors
Male
Middle Aged
Polymorphism, Single Nucleotide
Schizophrenia
Metadata
Show full item recordCitation
Effects of ZNF804A on auditory P300 response in schizophrenia. 2014, 4:e345 Transl PsychiatryPublisher
Nature Publishing GroupJournal
Translational psychiatryDOI
10.1038/tp.2013.115PubMed ID
24424391Additional Links
http://www.nature.com/tp/journal/v4/n1/full/tp2013115a.htmlAbstract
The common variant rs1344706 within the zinc-finger protein gene ZNF804A has been strongly implicated in schizophrenia (SZ) susceptibility by a series of recent genetic association studies. Although associated with a pattern of altered neural connectivity, evidence that increased risk is mediated by an effect on cognitive deficits associated with the disorder has been equivocal. This study investigated whether the same ZNF804A risk allele was associated with variation in the P300 auditory-evoked response, a cognitively relevant putative endophenotype for SZ. We compared P300 responses in carriers and noncarriers of the ZNF804A risk allele genotype groups in Irish patients and controls (n=97). P300 response was observed to vary according to genotype in this sample, such that risk allele carriers showed relatively higher P300 response compared with noncarriers. This finding accords with behavioural data reported by our group and others. It is also consistent with the idea that ZNF804A may have an impact on cortical efficiency, reflected in the higher levels of activations required to achieve comparable behavioural accuracy on the task used.Item Type
ArticleLanguage
enISSN
2158-3188ae974a485f413a2113503eed53cd6c53
10.1038/tp.2013.115
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