Effects of ZNF804A on auditory P300 response in schizophrenia.

Hdl Handle:
http://hdl.handle.net/10147/567069
Title:
Effects of ZNF804A on auditory P300 response in schizophrenia.
Authors:
O'Donoghue, T; Morris, D W; Fahey, C; Da Costa, A; Moore, S; Cummings, E; Leicht, G; Karch, S; Hoerold, D; Tropea, D; Foxe, J J; Gill, M; Corvin, A; Donohoe, G
Citation:
Effects of ZNF804A on auditory P300 response in schizophrenia. 2014, 4:e345 Transl Psychiatry
Publisher:
Nature Publishing Group
Journal:
Translational psychiatry
Issue Date:
Jan-2014
URI:
http://hdl.handle.net/10147/567069
DOI:
10.1038/tp.2013.115
PubMed ID:
24424391
Additional Links:
http://www.nature.com/tp/journal/v4/n1/full/tp2013115a.html
Abstract:
The common variant rs1344706 within the zinc-finger protein gene ZNF804A has been strongly implicated in schizophrenia (SZ) susceptibility by a series of recent genetic association studies. Although associated with a pattern of altered neural connectivity, evidence that increased risk is mediated by an effect on cognitive deficits associated with the disorder has been equivocal. This study investigated whether the same ZNF804A risk allele was associated with variation in the P300 auditory-evoked response, a cognitively relevant putative endophenotype for SZ. We compared P300 responses in carriers and noncarriers of the ZNF804A risk allele genotype groups in Irish patients and controls (n=97). P300 response was observed to vary according to genotype in this sample, such that risk allele carriers showed relatively higher P300 response compared with noncarriers. This finding accords with behavioural data reported by our group and others. It is also consistent with the idea that ZNF804A may have an impact on cortical efficiency, reflected in the higher levels of activations required to achieve comparable behavioural accuracy on the task used.
Item Type:
Article
Language:
en
Keywords:
SCHIZOPHRENIA; GENETICS
MeSH:
Adult; Electroencephalography; Endophenotypes; Event-Related Potentials, P300; Evoked Potentials, Auditory; Female; Genotype; Humans; Kruppel-Like Transcription Factors; Male; Middle Aged; Polymorphism, Single Nucleotide; Schizophrenia
ISSN:
2158-3188

Full metadata record

DC FieldValue Language
dc.contributor.authorO'Donoghue, Ten
dc.contributor.authorMorris, D Wen
dc.contributor.authorFahey, Cen
dc.contributor.authorDa Costa, Aen
dc.contributor.authorMoore, Sen
dc.contributor.authorCummings, Een
dc.contributor.authorLeicht, Gen
dc.contributor.authorKarch, Sen
dc.contributor.authorHoerold, Den
dc.contributor.authorTropea, Den
dc.contributor.authorFoxe, J Jen
dc.contributor.authorGill, Men
dc.contributor.authorCorvin, Aen
dc.contributor.authorDonohoe, Gen
dc.date.accessioned2015-08-17T09:21:09Zen
dc.date.available2015-08-17T09:21:09Zen
dc.date.issued2014-01en
dc.identifier.citationEffects of ZNF804A on auditory P300 response in schizophrenia. 2014, 4:e345 Transl Psychiatryen
dc.identifier.issn2158-3188en
dc.identifier.pmid24424391en
dc.identifier.doi10.1038/tp.2013.115en
dc.identifier.urihttp://hdl.handle.net/10147/567069en
dc.description.abstractThe common variant rs1344706 within the zinc-finger protein gene ZNF804A has been strongly implicated in schizophrenia (SZ) susceptibility by a series of recent genetic association studies. Although associated with a pattern of altered neural connectivity, evidence that increased risk is mediated by an effect on cognitive deficits associated with the disorder has been equivocal. This study investigated whether the same ZNF804A risk allele was associated with variation in the P300 auditory-evoked response, a cognitively relevant putative endophenotype for SZ. We compared P300 responses in carriers and noncarriers of the ZNF804A risk allele genotype groups in Irish patients and controls (n=97). P300 response was observed to vary according to genotype in this sample, such that risk allele carriers showed relatively higher P300 response compared with noncarriers. This finding accords with behavioural data reported by our group and others. It is also consistent with the idea that ZNF804A may have an impact on cortical efficiency, reflected in the higher levels of activations required to achieve comparable behavioural accuracy on the task used.en
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.relation.urlhttp://www.nature.com/tp/journal/v4/n1/full/tp2013115a.htmlen
dc.rightsArchived with thanks to Translational psychiatryen
dc.subjectSCHIZOPHRENIAen
dc.subjectGENETICSen
dc.subject.meshAdulten
dc.subject.meshElectroencephalographyen
dc.subject.meshEndophenotypesen
dc.subject.meshEvent-Related Potentials, P300en
dc.subject.meshEvoked Potentials, Auditoryen
dc.subject.meshFemaleen
dc.subject.meshGenotypeen
dc.subject.meshHumansen
dc.subject.meshKruppel-Like Transcription Factorsen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshPolymorphism, Single Nucleotideen
dc.subject.meshSchizophreniaen
dc.titleEffects of ZNF804A on auditory P300 response in schizophrenia.en
dc.typeArticleen
dc.identifier.journalTranslational psychiatryen
dc.description.fundingNo fundingen
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen

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