Influences of the colonic microbiome on the mucous gel layer in ulcerative colitis.
Authors
Lennon, GráinneBalfe, Aine
Earley, Helen
Devane, Liam A
Lavelle, Aonghus
Winter, Desmond C
Coffey, J Calvin
O'Connell, P Ronan
Issue Date
2014-04MeSH
BacteriaColitis, Ulcerative
Colon
Homeostasis
Host-Pathogen Interactions
Humans
Microbiota
Mucus
Metadata
Show full item recordCitation
Influences of the colonic microbiome on the mucous gel layer in ulcerative colitis., 5 (3):277-85 Gut MicrobesJournal
Gut microbesDOI
10.4161/gmic.28793PubMed ID
24714392Additional Links
http://www.tandfonline.com/doi/full/10.4161/gmic.28793Abstract
The colonic mucus gel layer (MGL) is a critical component of the innate immune system acting as a physical barrier to microbes, luminal insults, and toxins. Mucins are the major component of the MGL. Selected microbes have the potential to interact with, bind to, and metabolize mucins. The tolerance of the host to the presence of these microbes is critical to maintaining MGL homeostasis. In disease states such as ulcerative colitis (UC), both the mucosa associated microbes and the constituent MGL mucins have been shown to be altered. Evidence is accumulating that implicates the potential for mucin degrading bacteria to negatively impact the MGL and its stasis. These effects appear more pronounced in UC. This review is focused on the host-microbiome interactions within the setting of the MGL. Special focus is given to the mucolytic potential of microbes and their interactions in the setting of the colitic colon.Item Type
ArticleLanguage
enISSN
1949-0984ae974a485f413a2113503eed53cd6c53
10.4161/gmic.28793