The Impact of Immunosenescence on Pulmonary Disease.

Hdl Handle:
http://hdl.handle.net/10147/565675
Title:
The Impact of Immunosenescence on Pulmonary Disease.
Authors:
Murray, Michelle A; Chotirmall, Sanjay H
Affiliation:
1Department of Respiratory Medicine, Mater Misericordiae Hospital, Eccles Street, Dublin 7, Ireland. 2Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232.
Citation:
The Impact of Immunosenescence on Pulmonary Disease. 2015, 2015:692546 Mediators Inflamm.
Publisher:
Hindawi Publishing Corp.
Journal:
Mediators of inflammation
Issue Date:
Aug-2015
URI:
http://hdl.handle.net/10147/565675
DOI:
10.1155/2015/692546
PubMed ID:
26199462
Abstract:
The global population is aging with significant gains in life expectancy particularly in the developed world. Consequently, greater focus on understanding the processes that underlie physiological aging has occurred. Key facets of advancing age include genomic instability, telomere shortening, epigenetic changes, and declines in immune function termed immunosenescence. Immunosenescence and its associated chronic low grade systemic "inflamm-aging" contribute to the development and progression of pulmonary disease in older individuals. These physiological processes predispose to pulmonary infection and confer specific and unique clinical phenotypes observed in chronic respiratory disease including late-onset asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis. Emerging concepts of the gut and airway microbiome further complicate the interrelationship between host and microorganism particularly from an immunological perspective and especially so in the setting of immunosenescence. This review focuses on our current understanding of the aging process, immunosenescence, and how it can potentially impact on various pulmonary diseases and the human microbiome.
Item Type:
Article
Language:
en
Keywords:
POPLUATION HEALTH; GLOBAL HEALTH
ISSN:
1466-1861

Full metadata record

DC FieldValue Language
dc.contributor.authorMurray, Michelle Aen
dc.contributor.authorChotirmall, Sanjay Hen
dc.date.accessioned2015-08-06T11:53:30Zen
dc.date.available2015-08-06T11:53:30Zen
dc.date.issued2015-08en
dc.identifier.citationThe Impact of Immunosenescence on Pulmonary Disease. 2015, 2015:692546 Mediators Inflamm.en
dc.identifier.issn1466-1861en
dc.identifier.pmid26199462en
dc.identifier.doi10.1155/2015/692546en
dc.identifier.urihttp://hdl.handle.net/10147/565675en
dc.description.abstractThe global population is aging with significant gains in life expectancy particularly in the developed world. Consequently, greater focus on understanding the processes that underlie physiological aging has occurred. Key facets of advancing age include genomic instability, telomere shortening, epigenetic changes, and declines in immune function termed immunosenescence. Immunosenescence and its associated chronic low grade systemic "inflamm-aging" contribute to the development and progression of pulmonary disease in older individuals. These physiological processes predispose to pulmonary infection and confer specific and unique clinical phenotypes observed in chronic respiratory disease including late-onset asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis. Emerging concepts of the gut and airway microbiome further complicate the interrelationship between host and microorganism particularly from an immunological perspective and especially so in the setting of immunosenescence. This review focuses on our current understanding of the aging process, immunosenescence, and how it can potentially impact on various pulmonary diseases and the human microbiome.en
dc.language.isoenen
dc.publisherHindawi Publishing Corp.en
dc.rightsArchived with thanks to Mediators of inflammationen
dc.subjectPOPLUATION HEALTHen
dc.subjectGLOBAL HEALTHen
dc.titleThe Impact of Immunosenescence on Pulmonary Disease.en
dc.typeArticleen
dc.contributor.department1Department of Respiratory Medicine, Mater Misericordiae Hospital, Eccles Street, Dublin 7, Ireland. 2Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232.en
dc.identifier.journalMediators of inflammationen
dc.description.fundingNo fundingen
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen

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