Dose-related effects of vitamin D on immune responses in patients with clinically isolated syndrome and healthy control participants: study protocol for an exploratory randomized double- blind placebo-controlled trial.

Hdl Handle:
http://hdl.handle.net/10147/565674
Title:
Dose-related effects of vitamin D on immune responses in patients with clinically isolated syndrome and healthy control participants: study protocol for an exploratory randomized double- blind placebo-controlled trial.
Authors:
O'Connell, Karen; Kelly, Siobhan; Kinsella, Katie; Jordan, Sinead; Kenny, Orla; Murphy, David; Heffernan, Eric; O'Laoide, Risteard; O'Shea, Donal; McKenna, Carmel; Cassidy, Lorraine; Fletcher, Jean; Walsh, Cathal; Brady, Jennifer; McGuigan, Christopher; Tubridy, Niall; Hutchinson, Michael
Citation:
Dose-related effects of vitamin D on immune responses in patients with clinically isolated syndrome and healthy control participants: study protocol for an exploratory randomized double- blind placebo-controlled trial. 2013, 14:272 Trials
Journal:
Trials
Issue Date:
Aug-2013
URI:
http://hdl.handle.net/10147/565674
DOI:
10.1186/1745-6215-14-272
PubMed ID:
23981773
Additional Links:
http://www.trialsjournal.com/content/14/1/272
Abstract:
There is increasing evidence linking vitamin D deficiency to both susceptibility to, and severity of, multiple sclerosis (MS). Patients with the clinically isolated syndrome represent the initial presentation of a demyelinating disorder, and those with asymptomatic lesions on magnetic resonance imaging (MRI) are at risk of progression to clinically definite MS. The aims of this study are to examine the immunologic effects of vitamin D in both healthy individuals and in patients with clinically isolated syndrome, and in the latter group the effects on disease progression assessed by MRI and clinical measures.
Item Type:
Article
Language:
en
MeSH:
Biological Markers; Brain; CD4 Lymphocyte Count; Cholecalciferol; Clinical Protocols; Cytokines; Demyelinating Diseases; Disease Progression; Dose-Response Relationship, Drug; Double-Blind Method; Healthy Volunteers; Humans; Ireland; Leukocytes, Mononuclear; Magnetic Resonance Imaging; Multiple Sclerosis; Research Design; Time Factors; Treatment Outcome; Vitamin D
ISSN:
1745-6215

Full metadata record

DC FieldValue Language
dc.contributor.authorO'Connell, Karenen
dc.contributor.authorKelly, Siobhanen
dc.contributor.authorKinsella, Katieen
dc.contributor.authorJordan, Sineaden
dc.contributor.authorKenny, Orlaen
dc.contributor.authorMurphy, Daviden
dc.contributor.authorHeffernan, Ericen
dc.contributor.authorO'Laoide, Ristearden
dc.contributor.authorO'Shea, Donalen
dc.contributor.authorMcKenna, Carmelen
dc.contributor.authorCassidy, Lorraineen
dc.contributor.authorFletcher, Jeanen
dc.contributor.authorWalsh, Cathalen
dc.contributor.authorBrady, Jenniferen
dc.contributor.authorMcGuigan, Christopheren
dc.contributor.authorTubridy, Niallen
dc.contributor.authorHutchinson, Michaelen
dc.date.accessioned2015-08-06T10:41:16Zen
dc.date.available2015-08-06T10:41:16Zen
dc.date.issued2013-08en
dc.identifier.citationDose-related effects of vitamin D on immune responses in patients with clinically isolated syndrome and healthy control participants: study protocol for an exploratory randomized double- blind placebo-controlled trial. 2013, 14:272 Trialsen
dc.identifier.issn1745-6215en
dc.identifier.pmid23981773en
dc.identifier.doi10.1186/1745-6215-14-272en
dc.identifier.urihttp://hdl.handle.net/10147/565674en
dc.description.abstractThere is increasing evidence linking vitamin D deficiency to both susceptibility to, and severity of, multiple sclerosis (MS). Patients with the clinically isolated syndrome represent the initial presentation of a demyelinating disorder, and those with asymptomatic lesions on magnetic resonance imaging (MRI) are at risk of progression to clinically definite MS. The aims of this study are to examine the immunologic effects of vitamin D in both healthy individuals and in patients with clinically isolated syndrome, and in the latter group the effects on disease progression assessed by MRI and clinical measures.en
dc.language.isoenen
dc.relation.urlhttp://www.trialsjournal.com/content/14/1/272en
dc.rightsArchived with thanks to Trialsen
dc.subject.meshBiological Markersen
dc.subject.meshBrainen
dc.subject.meshCD4 Lymphocyte Counten
dc.subject.meshCholecalciferolen
dc.subject.meshClinical Protocolsen
dc.subject.meshCytokinesen
dc.subject.meshDemyelinating Diseasesen
dc.subject.meshDisease Progressionen
dc.subject.meshDose-Response Relationship, Drugen
dc.subject.meshDouble-Blind Methoden
dc.subject.meshHealthy Volunteersen
dc.subject.meshHumansen
dc.subject.meshIrelanden
dc.subject.meshLeukocytes, Mononuclearen
dc.subject.meshMagnetic Resonance Imagingen
dc.subject.meshMultiple Sclerosisen
dc.subject.meshResearch Designen
dc.subject.meshTime Factorsen
dc.subject.meshTreatment Outcomeen
dc.subject.meshVitamin Den
dc.titleDose-related effects of vitamin D on immune responses in patients with clinically isolated syndrome and healthy control participants: study protocol for an exploratory randomized double- blind placebo-controlled trial.en
dc.typeArticleen
dc.identifier.journalTrialsen
dc.description.fundingNo fundingen
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen

Related articles on PubMed

All Items in Lenus, The Irish Health Repository are protected by copyright, with all rights reserved, unless otherwise indicated.