Association between Dopamine Receptor D2 (DRD2) Variations rs6277 and rs1800497 and Cognitive Performance According to Risk Type for Psychosis: A Nested Case Control Study in a Finnish Population Sample.

Hdl Handle:
http://hdl.handle.net/10147/559421
Title:
Association between Dopamine Receptor D2 (DRD2) Variations rs6277 and rs1800497 and Cognitive Performance According to Risk Type for Psychosis: A Nested Case Control Study in a Finnish Population Sample.
Authors:
Ramsay, Hugh; Barnett, Jennifer H; Miettunen, Jouko; Mukkala, Sari; Mäki, Pirjo; Liuhanen, Johanna; Murray, Graham K; Jarvelin, Marjo-Riitta; Ollila, Hanna; Paunio, Tiina; Veijola, Juha
Affiliation:
1Department of Psychiatry, Centre for Clinical Neuroscience, University of Oulu, Oulu, Finland; Health Service Executive, Dublin, Ireland.
Citation:
Association between Dopamine Receptor D2 (DRD2) Variations rs6277 and rs1800497 and Cognitive Performance According to Risk Type for Psychosis: A Nested Case Control Study in a Finnish Population Sample. 2015, 10 (6):e0127602 PLoS ONE
Journal:
PloS one
Issue Date:
2015
URI:
http://hdl.handle.net/10147/559421
DOI:
10.1371/journal.pone.0127602
PubMed ID:
26114663
Additional Links:
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0127602
Abstract:
There is limited research regarding the association between genes and cognitive intermediate phenotypes in those at risk for psychotic disorders.; We measured the association between established psychosis risk variants in dopamine D2 receptor (DRD2) and cognitive performance in individuals at age 23 years and explored if associations between cognition and these variants differed according to the presence of familial or clinical risk for psychosis. The subjects of the Oulu Brain and Mind Study were drawn from the general population-based Northern Finland 1986 Birth Cohort (NFBC 1986). Using linear regression, we compared the associations between cognitive performance and two candidate DRD2 polymorphisms (rs6277 and rs1800497) between subjects having familial (n=61) and clinical (n=45) risk for psychosis and a random sample of participating NFBC 1986 controls (n=74). Cognitive performance was evaluated using a comprehensive battery of tests at follow-up.; Principal components factor analysis supported a three-factor model for cognitive measures. The minor allele of rs6277 was associated with poorer performance on a verbal factor (p=0.003) but this did not significantly interact with familial or clinical risk for psychosis. The minor allele of rs1800497 was associated with poorer performance on a psychomotor factor (p=0.038), though only in those at familial risk for psychotic disorders (interaction p=0.049).; The effect of two DRD2 SNPs on cognitive performance may differ according to risk type for psychosis, suggesting that cognitive intermediate phenotypes differ according to the type (familial or clinical) risk for psychosis.
Item Type:
Article
Language:
en
Keywords:
PSYCHIATRY; GENETICS; PSYCHOTIC DISORDER
ISSN:
1932-6203

Full metadata record

DC FieldValue Language
dc.contributor.authorRamsay, Hughen
dc.contributor.authorBarnett, Jennifer Hen
dc.contributor.authorMiettunen, Joukoen
dc.contributor.authorMukkala, Sarien
dc.contributor.authorMäki, Pirjoen
dc.contributor.authorLiuhanen, Johannaen
dc.contributor.authorMurray, Graham Ken
dc.contributor.authorJarvelin, Marjo-Riittaen
dc.contributor.authorOllila, Hannaen
dc.contributor.authorPaunio, Tiinaen
dc.contributor.authorVeijola, Juhaen
dc.date.accessioned2015-07-10T08:46:13Zen
dc.date.available2015-07-10T08:46:13Zen
dc.date.issued2015en
dc.identifier.citationAssociation between Dopamine Receptor D2 (DRD2) Variations rs6277 and rs1800497 and Cognitive Performance According to Risk Type for Psychosis: A Nested Case Control Study in a Finnish Population Sample. 2015, 10 (6):e0127602 PLoS ONEen
dc.identifier.issn1932-6203en
dc.identifier.pmid26114663en
dc.identifier.doi10.1371/journal.pone.0127602en
dc.identifier.urihttp://hdl.handle.net/10147/559421en
dc.description.abstractThere is limited research regarding the association between genes and cognitive intermediate phenotypes in those at risk for psychotic disorders.en
dc.description.abstractWe measured the association between established psychosis risk variants in dopamine D2 receptor (DRD2) and cognitive performance in individuals at age 23 years and explored if associations between cognition and these variants differed according to the presence of familial or clinical risk for psychosis. The subjects of the Oulu Brain and Mind Study were drawn from the general population-based Northern Finland 1986 Birth Cohort (NFBC 1986). Using linear regression, we compared the associations between cognitive performance and two candidate DRD2 polymorphisms (rs6277 and rs1800497) between subjects having familial (n=61) and clinical (n=45) risk for psychosis and a random sample of participating NFBC 1986 controls (n=74). Cognitive performance was evaluated using a comprehensive battery of tests at follow-up.en
dc.description.abstractPrincipal components factor analysis supported a three-factor model for cognitive measures. The minor allele of rs6277 was associated with poorer performance on a verbal factor (p=0.003) but this did not significantly interact with familial or clinical risk for psychosis. The minor allele of rs1800497 was associated with poorer performance on a psychomotor factor (p=0.038), though only in those at familial risk for psychotic disorders (interaction p=0.049).en
dc.description.abstractThe effect of two DRD2 SNPs on cognitive performance may differ according to risk type for psychosis, suggesting that cognitive intermediate phenotypes differ according to the type (familial or clinical) risk for psychosis.en
dc.language.isoenen
dc.relation.urlhttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0127602en
dc.rightsArchived with thanks to PloS oneen
dc.subjectPSYCHIATRYen
dc.subjectGENETICSen
dc.subjectPSYCHOTIC DISORDERen
dc.titleAssociation between Dopamine Receptor D2 (DRD2) Variations rs6277 and rs1800497 and Cognitive Performance According to Risk Type for Psychosis: A Nested Case Control Study in a Finnish Population Sample.en
dc.typeArticleen
dc.contributor.department1Department of Psychiatry, Centre for Clinical Neuroscience, University of Oulu, Oulu, Finland; Health Service Executive, Dublin, Ireland.en
dc.identifier.journalPloS oneen

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