A prolonged outbreak of invasive meningococcal disease in an extended Irish Traveller family across three Health Service Executive (HSE) areas in Ireland, 2010 to 2013.

Hdl Handle:
http://hdl.handle.net/10147/559419
Title:
A prolonged outbreak of invasive meningococcal disease in an extended Irish Traveller family across three Health Service Executive (HSE) areas in Ireland, 2010 to 2013.
Authors:
O Connor, L; Ward, M; Bennett, D; Mulhall, R; O Lorcain, P; Cunney, R; McDermott, R; Neville, E; Heslin, J; FitzGerald, R; Meyler, K; Conlon, M; Clarke, A; Corcoran, B; Fitzpatrick, G; O Connor, B; Flanagan, P; O Flanagan, D; Cotter, S
Citation:
A prolonged outbreak of invasive meningococcal disease in an extended Irish Traveller family across three Health Service Executive (HSE) areas in Ireland, 2010 to 2013. 2015, 20 (21): Euro Surveill.
Journal:
Euro surveillance : bulletin Européen sur les maladies transmissibles = European communicable disease bulletin
Issue Date:
2015
URI:
http://hdl.handle.net/10147/559419
PubMed ID:
26062560
Item Type:
Article
Language:
en
Description:
Between March 2010 and November 2013 eight laboratory-confirmed cases of serogroup B, invasive meningococcal disease (IMD) were identified in an extended Irish Traveller family across three Health Service Executive (HSE) areas of Ireland. Cases were aged between 5 and 46 months, and were either a cousin or sibling of another case. All eight cases survived. Chemoprophylaxis was given to relevant nuclear family members and close contacts on each occasion, but failed to prevent further cases. Neisseria meningitidis isolates from six cases were highly related, belonging to the ST-41/44 clonal complex, and shared the porA designation 7–2,4. In November 2013, the outbreak control team recommended that directly observed ciprofloxacin chemoprophylaxis be administered simultaneously to the extended family, and that the four component meningococcal B (4CMenB) vaccine be administered to family members aged 2 months to 23 years inclusive and relevant close contacts of the eighth case. Subsequently these recommendations were implemented at three regional clinics. Additionally pharyngeal swabs (n=112) were collected to assess carriage rates of N. meningitidis in this extended family. Pharyngeal carriage of N. meningitidis was detected in 15 (13%) family members. From the epidemiological investigation and carriage study overcrowding was the most likely risk factor identified in this outbreak. To date, the combination of directly observed ciprofloxacin chemoprophylaxis and use of 4CMenB vaccine have controlled the outbreak with no further cases diagnosed.
Keywords:
INFECTIOUS DISEASE; TRAVELLERS AND GYPSIES; PUBLIC HEALTH
Local subject classification:
PUBLIC HEALTH DEPARTMENT
ISSN:
1560-7917

Full metadata record

DC FieldValue Language
dc.contributor.authorO Connor, Len
dc.contributor.authorWard, Men
dc.contributor.authorBennett, Den
dc.contributor.authorMulhall, Ren
dc.contributor.authorO Lorcain, Pen
dc.contributor.authorCunney, Ren
dc.contributor.authorMcDermott, Ren
dc.contributor.authorNeville, Een
dc.contributor.authorHeslin, Jen
dc.contributor.authorFitzGerald, Ren
dc.contributor.authorMeyler, Ken
dc.contributor.authorConlon, Men
dc.contributor.authorClarke, Aen
dc.contributor.authorCorcoran, Ben
dc.contributor.authorFitzpatrick, Gen
dc.contributor.authorO Connor, Ben
dc.contributor.authorFlanagan, Pen
dc.contributor.authorO Flanagan, Den
dc.contributor.authorCotter, Sen
dc.date.accessioned2015-07-10T08:25:46Zen
dc.date.available2015-07-10T08:25:46Zen
dc.date.issued2015en
dc.identifier.citationA prolonged outbreak of invasive meningococcal disease in an extended Irish Traveller family across three Health Service Executive (HSE) areas in Ireland, 2010 to 2013. 2015, 20 (21): Euro Surveill.en
dc.identifier.issn1560-7917en
dc.identifier.pmid26062560en
dc.identifier.urihttp://hdl.handle.net/10147/559419en
dc.descriptionBetween March 2010 and November 2013 eight laboratory-confirmed cases of serogroup B, invasive meningococcal disease (IMD) were identified in an extended Irish Traveller family across three Health Service Executive (HSE) areas of Ireland. Cases were aged between 5 and 46 months, and were either a cousin or sibling of another case. All eight cases survived. Chemoprophylaxis was given to relevant nuclear family members and close contacts on each occasion, but failed to prevent further cases. Neisseria meningitidis isolates from six cases were highly related, belonging to the ST-41/44 clonal complex, and shared the porA designation 7–2,4. In November 2013, the outbreak control team recommended that directly observed ciprofloxacin chemoprophylaxis be administered simultaneously to the extended family, and that the four component meningococcal B (4CMenB) vaccine be administered to family members aged 2 months to 23 years inclusive and relevant close contacts of the eighth case. Subsequently these recommendations were implemented at three regional clinics. Additionally pharyngeal swabs (n=112) were collected to assess carriage rates of N. meningitidis in this extended family. Pharyngeal carriage of N. meningitidis was detected in 15 (13%) family members. From the epidemiological investigation and carriage study overcrowding was the most likely risk factor identified in this outbreak. To date, the combination of directly observed ciprofloxacin chemoprophylaxis and use of 4CMenB vaccine have controlled the outbreak with no further cases diagnosed.en
dc.language.isoenen
dc.rightsArchived with thanks to Euro surveillance : bulletin Européen sur les maladies transmissibles = European communicable disease bulletinen
dc.subjectINFECTIOUS DISEASEen
dc.subjectTRAVELLERS AND GYPSIESen
dc.subjectPUBLIC HEALTHen
dc.subject.otherPUBLIC HEALTH DEPARTMENTen
dc.titleA prolonged outbreak of invasive meningococcal disease in an extended Irish Traveller family across three Health Service Executive (HSE) areas in Ireland, 2010 to 2013.en
dc.typeArticleen
dc.identifier.journalEuro surveillance : bulletin Européen sur les maladies transmissibles = European communicable disease bulletinen

Related articles on PubMed

All Items in Lenus, The Irish Health Repository are protected by copyright, with all rights reserved, unless otherwise indicated.