Comparison of semi-automated and manual measurements of carotid intima-media thickening.

Hdl Handle:
http://hdl.handle.net/10147/559312
Title:
Comparison of semi-automated and manual measurements of carotid intima-media thickening.
Authors:
Mac Ananey, Oscar; Mellotte, Greg; Maher, Vincent
Affiliation:
Tallaght Hospital
Citation:
Comparison of semi-automated and manual measurements of carotid intima-media thickening. 2014, 2014:531389 Biomed Res Int
Publisher:
Hindawi Publishing Corporation
Journal:
BioMed research international
Issue Date:
2014
URI:
http://hdl.handle.net/10147/559312
DOI:
10.1155/2014/531389
PubMed ID:
24579082
Abstract:
Carotid intima-media thickening (CIMT) is a marker of both arteriosclerotic and atherosclerotic risks. Technological advances have semiautomated CIMT image acquisition and quantification. Studies comparing manual and automated methods have yielded conflicting results possibly due to plaque inclusion in measurements. Low atherosclerotic risk subjects (n = 126) were recruited to minimise the effect of focal atherosclerotic lesions on CIMT variability. CIMT was assessed by high-resolution B-mode ultrasound (Philips HDX7E, Phillips, UK) images of the common carotid artery using both manual and semiautomated methods (QLAB, Phillips, UK). Intraclass correlation coefficient (ICC) and the mean differences of paired measurements (Bland-Altman method) were used to compare both methodologies. The ICC of manual (0.547 ± 0.095 mm) and automated (0.524 ± 0.068 mm) methods was R = 0.74 and an absolute mean bias ± SD of 0.023 ± 0.052 mm was observed. Interobserver and intraobserver ICC were greater for automated (R = 0.94 and 0.99) compared to manual (R = 0.72 and 0.88) methods. Although not considered to be clinically significant, manual measurements yielded higher values compared to automated measurements. Automated measurements were more reproducible and showed lower interobserver variation compared to manual measurements. These results offer important considerations for large epidemiological studies.
Item Type:
Article
Language:
en
Keywords:
EPIDEMIOLOGY
MeSH:
Adult; Carotid Intima-Media Thickness; Coronary Artery Disease; Endothelium, Vascular; Female; Humans; Male; Middle Aged
ISSN:
2314-6141

Full metadata record

DC FieldValue Language
dc.contributor.authorMac Ananey, Oscaren
dc.contributor.authorMellotte, Gregen
dc.contributor.authorMaher, Vincenten
dc.date.accessioned2015-07-09T11:37:07Zen
dc.date.available2015-07-09T11:37:07Zen
dc.date.issued2014en
dc.identifier.citationComparison of semi-automated and manual measurements of carotid intima-media thickening. 2014, 2014:531389 Biomed Res Inten
dc.identifier.issn2314-6141en
dc.identifier.pmid24579082en
dc.identifier.doi10.1155/2014/531389en
dc.identifier.urihttp://hdl.handle.net/10147/559312en
dc.description.abstractCarotid intima-media thickening (CIMT) is a marker of both arteriosclerotic and atherosclerotic risks. Technological advances have semiautomated CIMT image acquisition and quantification. Studies comparing manual and automated methods have yielded conflicting results possibly due to plaque inclusion in measurements. Low atherosclerotic risk subjects (n = 126) were recruited to minimise the effect of focal atherosclerotic lesions on CIMT variability. CIMT was assessed by high-resolution B-mode ultrasound (Philips HDX7E, Phillips, UK) images of the common carotid artery using both manual and semiautomated methods (QLAB, Phillips, UK). Intraclass correlation coefficient (ICC) and the mean differences of paired measurements (Bland-Altman method) were used to compare both methodologies. The ICC of manual (0.547 ± 0.095 mm) and automated (0.524 ± 0.068 mm) methods was R = 0.74 and an absolute mean bias ± SD of 0.023 ± 0.052 mm was observed. Interobserver and intraobserver ICC were greater for automated (R = 0.94 and 0.99) compared to manual (R = 0.72 and 0.88) methods. Although not considered to be clinically significant, manual measurements yielded higher values compared to automated measurements. Automated measurements were more reproducible and showed lower interobserver variation compared to manual measurements. These results offer important considerations for large epidemiological studies.en
dc.language.isoenen
dc.publisherHindawi Publishing Corporationen
dc.rightsArchived with thanks to BioMed research internationalen
dc.subjectEPIDEMIOLOGYen
dc.subject.meshAdulten
dc.subject.meshCarotid Intima-Media Thicknessen
dc.subject.meshCoronary Artery Diseaseen
dc.subject.meshEndothelium, Vascularen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.titleComparison of semi-automated and manual measurements of carotid intima-media thickening.en
dc.typeArticleen
dc.contributor.departmentTallaght Hospitalen
dc.identifier.journalBioMed research internationalen
dc.description.fundingNo fundingen
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen

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