Clinical, immunological and treatment-related factors associated with normalised CD4+/CD8+ T-cell ratio: effect of naïve and memory T-cell subsets.

Hdl Handle:
http://hdl.handle.net/10147/559257
Title:
Clinical, immunological and treatment-related factors associated with normalised CD4+/CD8+ T-cell ratio: effect of naïve and memory T-cell subsets.
Authors:
Tinago, Willard; Coghlan, Elizabeth; Macken, Alan; McAndrews, Julie; Doak, Brenda; Prior-Fuller, Charlotte; Lambert, John S; Sheehan, Gerard J; Mallon, Patrick W G
Citation:
Clinical, immunological and treatment-related factors associated with normalised CD4+/CD8+ T-cell ratio: effect of naïve and memory T-cell subsets. 2014, 9 (5):e97011 PLoS ONE
Journal:
PloS one
Issue Date:
2014
URI:
http://hdl.handle.net/10147/559257
DOI:
10.1371/journal.pone.0097011
PubMed ID:
24816636
Abstract:
Although effective antiretroviral therapy(ART) increases CD4+ T-cell count, responses to ART vary considerably and only a minority of patients normalise their CD4+/CD8+ ratio. Although retention of naïve CD4+ T-cells is thought to predict better immune responses, relationships between CD4+ and CD8+ T-cell subsets and CD4+/CD8+ ratio have not been well described.
Item Type:
Article
Language:
en
Keywords:
IMMUNE SYSTEM
MeSH:
Adult; Anti-Retroviral Agents; Antigens, CD45; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Count; Cross-Sectional Studies; Female; Flow Cytometry; HIV Infections; Humans; Immunologic Memory; L-Selectin; Linear Models; Male; Middle Aged
ISSN:
1932-6203
Sponsors:
Work was supported by an unrestricted fund from GlaxoSmithKline. http://www.gsk.ie/gsk_at_a_glance/glaxosmithkline_dublin.html. The funder shad no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Full metadata record

DC FieldValue Language
dc.contributor.authorTinago, Willarden
dc.contributor.authorCoghlan, Elizabethen
dc.contributor.authorMacken, Alanen
dc.contributor.authorMcAndrews, Julieen
dc.contributor.authorDoak, Brendaen
dc.contributor.authorPrior-Fuller, Charlotteen
dc.contributor.authorLambert, John Sen
dc.contributor.authorSheehan, Gerard Jen
dc.contributor.authorMallon, Patrick W Gen
dc.date.accessioned2015-07-08T13:46:31Zen
dc.date.available2015-07-08T13:46:31Zen
dc.date.issued2014en
dc.identifier.citationClinical, immunological and treatment-related factors associated with normalised CD4+/CD8+ T-cell ratio: effect of naïve and memory T-cell subsets. 2014, 9 (5):e97011 PLoS ONEen
dc.identifier.issn1932-6203en
dc.identifier.pmid24816636en
dc.identifier.doi10.1371/journal.pone.0097011en
dc.identifier.urihttp://hdl.handle.net/10147/559257en
dc.description.abstractAlthough effective antiretroviral therapy(ART) increases CD4+ T-cell count, responses to ART vary considerably and only a minority of patients normalise their CD4+/CD8+ ratio. Although retention of naïve CD4+ T-cells is thought to predict better immune responses, relationships between CD4+ and CD8+ T-cell subsets and CD4+/CD8+ ratio have not been well described.en
dc.description.sponsorshipWork was supported by an unrestricted fund from GlaxoSmithKline. http://www.gsk.ie/gsk_at_a_glance/glaxosmithkline_dublin.html. The funder shad no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en
dc.language.isoenen
dc.rightsArchived with thanks to PloS oneen
dc.subjectIMMUNE SYSTEMen
dc.subject.meshAdulten
dc.subject.meshAnti-Retroviral Agentsen
dc.subject.meshAntigens, CD45en
dc.subject.meshCD4-Positive T-Lymphocytesen
dc.subject.meshCD8-Positive T-Lymphocytesen
dc.subject.meshCell Counten
dc.subject.meshCross-Sectional Studiesen
dc.subject.meshFemaleen
dc.subject.meshFlow Cytometryen
dc.subject.meshHIV Infectionsen
dc.subject.meshHumansen
dc.subject.meshImmunologic Memoryen
dc.subject.meshL-Selectinen
dc.subject.meshLinear Modelsen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.titleClinical, immunological and treatment-related factors associated with normalised CD4+/CD8+ T-cell ratio: effect of naïve and memory T-cell subsets.en
dc.typeArticleen
dc.identifier.journalPloS oneen
dc.description.fundingOtheren
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen

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