Sickle cell disease: time for a targeted neonatal screening programme.

Hdl Handle:
http://hdl.handle.net/10147/559231
Title:
Sickle cell disease: time for a targeted neonatal screening programme.
Authors:
Gibbons, C; Geoghegan, R; Conroy, H; Lippacott, S; O'Brien, D; Lynam, P; Langabeer, L; Cotter, M; Smith, O; McMahon, C
Citation:
Sickle cell disease: time for a targeted neonatal screening programme. 2015, 108 (2):43-5 Ir Med J
Publisher:
Irish Medical Journal
Journal:
Irish medical journal
Issue Date:
Feb-2015
URI:
http://hdl.handle.net/10147/559231
PubMed ID:
25803954
Abstract:
Ireland has seen a steady increase in paediatric sickle cell disease (SCD). In 2005, only 25% of children with SCD were referred to the haemoglobinopathy service in their first year. A non-funded screening programme was implemented. This review aimed to assess the impact screening has had. All children referred to the haemoglobinopathy service born in Ireland after 2005 were identified. Data was collected from the medical chart and laboratory system. Information was analysed using Microsoft Excel. 77 children with SCD were identified. The median age at antibiotic commencement in the screened group was 56 days compared with 447 days in the unscreened group, p = < 0.0003. 22 (28%) of infants were born in centre's that do not screen and 17 (81%) were over 6 months old at referral, compared with 14 (21%) in the screened group. 6 (27%) of those in the unscreened group presented in acute crisis compared with 2 (3%) in the screened population. The point prevalence of SCD in Ireland is 0.2% in children under 15 yr of African and Asian descent. We identified delays in referral and treatment, which reflect the lack of government funded support and policy. We suggest all maternity units commence screening for newborns at risk of SCD. It is a cost effective intervention with a number needed to screen of just 4 to prevent a potentially fatal crisis.
Item Type:
Article
Language:
en
Keywords:
SICKLE CELL DISEASE; SCREENING; NEONATE
MeSH:
Anemia, Sickle Cell; Child; Humans; Infant, Newborn; Ireland; Neonatal Screening; Referral and Consultation; Retrospective Studies
ISSN:
0332-3102

Full metadata record

DC FieldValue Language
dc.contributor.authorGibbons, Cen
dc.contributor.authorGeoghegan, Ren
dc.contributor.authorConroy, Hen
dc.contributor.authorLippacott, Sen
dc.contributor.authorO'Brien, Den
dc.contributor.authorLynam, Pen
dc.contributor.authorLangabeer, Len
dc.contributor.authorCotter, Men
dc.contributor.authorSmith, Oen
dc.contributor.authorMcMahon, Cen
dc.date.accessioned2015-07-08T11:27:14Zen
dc.date.available2015-07-08T11:27:14Zen
dc.date.issued2015-02en
dc.identifier.citationSickle cell disease: time for a targeted neonatal screening programme. 2015, 108 (2):43-5 Ir Med Jen
dc.identifier.issn0332-3102en
dc.identifier.pmid25803954en
dc.identifier.urihttp://hdl.handle.net/10147/559231en
dc.description.abstractIreland has seen a steady increase in paediatric sickle cell disease (SCD). In 2005, only 25% of children with SCD were referred to the haemoglobinopathy service in their first year. A non-funded screening programme was implemented. This review aimed to assess the impact screening has had. All children referred to the haemoglobinopathy service born in Ireland after 2005 were identified. Data was collected from the medical chart and laboratory system. Information was analysed using Microsoft Excel. 77 children with SCD were identified. The median age at antibiotic commencement in the screened group was 56 days compared with 447 days in the unscreened group, p = < 0.0003. 22 (28%) of infants were born in centre's that do not screen and 17 (81%) were over 6 months old at referral, compared with 14 (21%) in the screened group. 6 (27%) of those in the unscreened group presented in acute crisis compared with 2 (3%) in the screened population. The point prevalence of SCD in Ireland is 0.2% in children under 15 yr of African and Asian descent. We identified delays in referral and treatment, which reflect the lack of government funded support and policy. We suggest all maternity units commence screening for newborns at risk of SCD. It is a cost effective intervention with a number needed to screen of just 4 to prevent a potentially fatal crisis.en
dc.language.isoenen
dc.publisherIrish Medical Journalen
dc.rightsArchived with thanks to Irish medical journalen
dc.subjectSICKLE CELL DISEASEen
dc.subjectSCREENINGen
dc.subjectNEONATEen
dc.subject.meshAnemia, Sickle Cellen
dc.subject.meshChilden
dc.subject.meshHumansen
dc.subject.meshInfant, Newbornen
dc.subject.meshIrelanden
dc.subject.meshNeonatal Screeningen
dc.subject.meshReferral and Consultationen
dc.subject.meshRetrospective Studiesen
dc.titleSickle cell disease: time for a targeted neonatal screening programme.en
dc.typeArticleen
dc.identifier.journalIrish medical journalen
dc.description.fundingNo fundingen
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen

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