The European I-MOVE Multicentre 2013-2014 Case-Control Study. Homogeneous moderate influenza vaccine effectiveness against A(H1N1)pdm09 and heterogenous results by country against A(H3N2).

Hdl Handle:
http://hdl.handle.net/10147/559160
Title:
The European I-MOVE Multicentre 2013-2014 Case-Control Study. Homogeneous moderate influenza vaccine effectiveness against A(H1N1)pdm09 and heterogenous results by country against A(H3N2).
Authors:
Valenciano, Marta; Kissling, Esther; Reuss, Annicka; Jiménez-Jorge, Silvia; Horváth, Judit K; Donnell, Joan M O; Pitigoi, Daniela; Machado, Ausenda; Pozo, Francisco
Affiliation:
1Epidemiology Department, EpiConcept, Paris, France. Electronic address: m.valenciano@epiconcept.fr. 2Epidemiology Department, EpiConcept, Paris, France. 3Department for Infectious Disease Epidemiology Respiratory Infections Unit, Robert Koch Institute, Berlin, Germany. 4National Centre of Epidemiology/CIBER Epidemiología y Salud Pública (CIBERESP), Institute of Health Carlos III, Madrid, Spain. 5Department of Public Health, Strategic Planning and Epidemiology, Office of the Chief Medical Officer, Budapest, Hungary. 6Health Protection Surveillance Centre, Dublin, Ireland. 7UMF Carol Davila, INCDMI Cantacuzino, Bucharest, Romania. 8Department of Epidemiology, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal. 9National Centre for Microbiology, National Influenza Centre-Institute of Health Carlos III, Madrid, Spain.
Citation:
The European I-MOVE Multicentre 2013-2014 Case-Control Study. Homogeneous moderate influenza vaccine effectiveness against A(H1N1)pdm09 and heterogenous results by country against A(H3N2). 2015, 33 (24):2813-22 Vaccine
Journal:
Vaccine
Issue Date:
4-Jun-2015
URI:
http://hdl.handle.net/10147/559160
DOI:
10.1016/j.vaccine.2015.04.012
PubMed ID:
25936723
Abstract:
In the first five I-MOVE (Influenza Monitoring Vaccine Effectiveness in Europe) influenza seasons vaccine effectiveness (VE) results were relatively homogenous among participating study sites. In 2013-2014, we undertook a multicentre case-control study based on sentinel practitioner surveillance networks in six European Union (EU) countries to measure 2013-2014 influenza VE against medically-attended influenza-like illness (ILI) laboratory-confirmed as influenza. Influenza A(H3N2) and A(H1N1)pdm09 viruses co-circulated during the season.; Practitioners systematically selected ILI patients to swab within eight days of symptom onset. We compared cases (ILI positive to influenza A(H3N2) or A(H1N1)pdm09) to influenza negative patients. We calculated VE for the two influenza A subtypes and adjusted for potential confounders. We calculated heterogeneity between sites using the I(2) index and Cochrane's Q test. If the I(2) was <50%, we estimated pooled VE as (1 minus the OR)×100 using a one-stage model with study site as a fixed effect. If the I(2) was >49% we used a two-stage random effects model.; We included in the A(H1N1)pdm09 analysis 531 cases and 1712 controls and in the A(H3N2) analysis 623 cases and 1920 controls. For A(H1N1)pdm09, the Q test (p=0.695) and the I(2) index (0%) suggested no heterogeneity of adjusted VE between study sites. Using a one-stage model, the overall pooled adjusted VE against influenza A(H1N1)pdm2009 was 47.5% (95% CI: 16.4-67.0). For A(H3N2), the I(2) was 51.5% (p=0.067). Using a two-stage model for the pooled analysis, the adjusted VE against A(H3N2) was 29.7 (95% CI: -34.4-63.2).; The results suggest a moderate 2013-2014 influenza VE against A(H1N1)pdm09 and a low VE against A(H3N2). The A(H3N2) estimates were heterogeneous among study sites. Larger sample sizes by study site are needed to prevent statistical heterogeneity, decrease variability and allow for two-stage pooled VE for all subgroup analyses.
Item Type:
Article
Language:
en
Keywords:
VACCINES; INFLUENZA
ISSN:
1873-2518

Full metadata record

DC FieldValue Language
dc.contributor.authorValenciano, Martaen
dc.contributor.authorKissling, Estheren
dc.contributor.authorReuss, Annickaen
dc.contributor.authorJiménez-Jorge, Silviaen
dc.contributor.authorHorváth, Judit Ken
dc.contributor.authorDonnell, Joan M Oen
dc.contributor.authorPitigoi, Danielaen
dc.contributor.authorMachado, Ausendaen
dc.contributor.authorPozo, Franciscoen
dc.date.accessioned2015-07-07T14:09:32Zen
dc.date.available2015-07-07T14:09:32Zen
dc.date.issued2015-06-04en
dc.identifier.citationThe European I-MOVE Multicentre 2013-2014 Case-Control Study. Homogeneous moderate influenza vaccine effectiveness against A(H1N1)pdm09 and heterogenous results by country against A(H3N2). 2015, 33 (24):2813-22 Vaccineen
dc.identifier.issn1873-2518en
dc.identifier.pmid25936723en
dc.identifier.doi10.1016/j.vaccine.2015.04.012en
dc.identifier.urihttp://hdl.handle.net/10147/559160en
dc.description.abstractIn the first five I-MOVE (Influenza Monitoring Vaccine Effectiveness in Europe) influenza seasons vaccine effectiveness (VE) results were relatively homogenous among participating study sites. In 2013-2014, we undertook a multicentre case-control study based on sentinel practitioner surveillance networks in six European Union (EU) countries to measure 2013-2014 influenza VE against medically-attended influenza-like illness (ILI) laboratory-confirmed as influenza. Influenza A(H3N2) and A(H1N1)pdm09 viruses co-circulated during the season.en
dc.description.abstractPractitioners systematically selected ILI patients to swab within eight days of symptom onset. We compared cases (ILI positive to influenza A(H3N2) or A(H1N1)pdm09) to influenza negative patients. We calculated VE for the two influenza A subtypes and adjusted for potential confounders. We calculated heterogeneity between sites using the I(2) index and Cochrane's Q test. If the I(2) was <50%, we estimated pooled VE as (1 minus the OR)×100 using a one-stage model with study site as a fixed effect. If the I(2) was >49% we used a two-stage random effects model.en
dc.description.abstractWe included in the A(H1N1)pdm09 analysis 531 cases and 1712 controls and in the A(H3N2) analysis 623 cases and 1920 controls. For A(H1N1)pdm09, the Q test (p=0.695) and the I(2) index (0%) suggested no heterogeneity of adjusted VE between study sites. Using a one-stage model, the overall pooled adjusted VE against influenza A(H1N1)pdm2009 was 47.5% (95% CI: 16.4-67.0). For A(H3N2), the I(2) was 51.5% (p=0.067). Using a two-stage model for the pooled analysis, the adjusted VE against A(H3N2) was 29.7 (95% CI: -34.4-63.2).en
dc.description.abstractThe results suggest a moderate 2013-2014 influenza VE against A(H1N1)pdm09 and a low VE against A(H3N2). The A(H3N2) estimates were heterogeneous among study sites. Larger sample sizes by study site are needed to prevent statistical heterogeneity, decrease variability and allow for two-stage pooled VE for all subgroup analyses.en
dc.language.isoenen
dc.rightsArchived with thanks to Vaccineen
dc.subjectVACCINESen
dc.subjectINFLUENZAen
dc.titleThe European I-MOVE Multicentre 2013-2014 Case-Control Study. Homogeneous moderate influenza vaccine effectiveness against A(H1N1)pdm09 and heterogenous results by country against A(H3N2).en
dc.typeArticleen
dc.contributor.department1Epidemiology Department, EpiConcept, Paris, France. Electronic address: m.valenciano@epiconcept.fr. 2Epidemiology Department, EpiConcept, Paris, France. 3Department for Infectious Disease Epidemiology Respiratory Infections Unit, Robert Koch Institute, Berlin, Germany. 4National Centre of Epidemiology/CIBER Epidemiología y Salud Pública (CIBERESP), Institute of Health Carlos III, Madrid, Spain. 5Department of Public Health, Strategic Planning and Epidemiology, Office of the Chief Medical Officer, Budapest, Hungary. 6Health Protection Surveillance Centre, Dublin, Ireland. 7UMF Carol Davila, INCDMI Cantacuzino, Bucharest, Romania. 8Department of Epidemiology, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal. 9National Centre for Microbiology, National Influenza Centre-Institute of Health Carlos III, Madrid, Spain.en
dc.identifier.journalVaccineen

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