Oxytocin is unequally distributed in a bag of normal saline - true or false?

Hdl Handle:
http://hdl.handle.net/10147/559123
Title:
Oxytocin is unequally distributed in a bag of normal saline - true or false?
Authors:
Chummun, K; O’Hora, H; Gaudel, C; Webster, P; Ogunlewe, O; Boylan, P
Publisher:
Irish Medical Journal
Journal:
Irish Medical Journal
Issue Date:
May-2015
URI:
http://hdl.handle.net/10147/559123
Abstract:
Oxytocin infusion used in labour can sometimes be left hung on the stand for many hours. There has been no study to determine if oxytocin is equally distributed throughout the infusion bag and if the distribution stays the same with time. We postulated that there may be settling of the molecules such that oxytocin concentrates at the bottom of the infusion bag. Eight infusion bags were prepared by mixing 10 IU of oxytocin in 1 litre of normal saline. The infusion bags were hung on infusion stands for 8 hours after which 10 samples of 100 mls of the solution from each bag were taken in different containers and the concentration of oxytocin calculated using oxytocin specific Enzyme Immunoassay (EIA) in the different samples. No statistically significant correlation between the oxytocin concentration and the sample number was observed (p-value = 0.738). There was no obvious relationship between oxytocin concentration and the sample number in each bag. There was no evidence to suggest that a linear oxytocin concentration gradient develops in a bag of normal saline over an 8-hour period. In fact the distribution appears to be random and unequal.
Item Type:
Article
Language:
en
Keywords:
CHILDBIRTH; PREGNANCY

Full metadata record

DC FieldValue Language
dc.contributor.authorChummun, Ken
dc.contributor.authorO’Hora, Hen
dc.contributor.authorGaudel, Cen
dc.contributor.authorWebster, Pen
dc.contributor.authorOgunlewe, Oen
dc.contributor.authorBoylan, Pen
dc.date.accessioned2015-07-07T10:41:28Zen
dc.date.available2015-07-07T10:41:28Zen
dc.date.issued2015-05en
dc.identifier.urihttp://hdl.handle.net/10147/559123en
dc.description.abstractOxytocin infusion used in labour can sometimes be left hung on the stand for many hours. There has been no study to determine if oxytocin is equally distributed throughout the infusion bag and if the distribution stays the same with time. We postulated that there may be settling of the molecules such that oxytocin concentrates at the bottom of the infusion bag. Eight infusion bags were prepared by mixing 10 IU of oxytocin in 1 litre of normal saline. The infusion bags were hung on infusion stands for 8 hours after which 10 samples of 100 mls of the solution from each bag were taken in different containers and the concentration of oxytocin calculated using oxytocin specific Enzyme Immunoassay (EIA) in the different samples. No statistically significant correlation between the oxytocin concentration and the sample number was observed (p-value = 0.738). There was no obvious relationship between oxytocin concentration and the sample number in each bag. There was no evidence to suggest that a linear oxytocin concentration gradient develops in a bag of normal saline over an 8-hour period. In fact the distribution appears to be random and unequal.en
dc.language.isoenen
dc.publisherIrish Medical Journalen
dc.subjectCHILDBIRTHen
dc.subjectPREGNANCYen
dc.titleOxytocin is unequally distributed in a bag of normal saline - true or false?en
dc.typeArticleen
dc.identifier.journalIrish Medical Journalen
dc.description.fundingNo fundingen
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen
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