PTPN22 is associated with susceptibility to psoriatic arthritis but not psoriasis: evidence for a further PsA-specific risk locus.

Hdl Handle:
http://hdl.handle.net/10147/559093
Title:
PTPN22 is associated with susceptibility to psoriatic arthritis but not psoriasis: evidence for a further PsA-specific risk locus.
Authors:
Bowes, John; Loehr, Sabine; Budu-Aggrey, Ashley; Uebe, Steffen; Bruce, Ian N; Feletar, Marie; Marzo-Ortega, Helena; Helliwell, Philip; Ryan, Anthony W; Kane, David; Korendowych, Eleanor; Alenius, Gerd-Marie; Giardina, Emiliano; Packham, Jonathan; McManus, Ross; FitzGerald, Oliver; Brown, Matthew A; Behrens, Frank; Burkhardt, Harald; McHugh, Neil; Huffmeier, Ulrike; Ho, Pauline; Reis, Andre; Barton, Anne
Affiliation:
1Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute for Inflammation and Repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK. 2Institute of Human Genetics, University of Erlangen-Nuremberg, Erlangen, Germany. 3Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute for Inflammation and Repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK. 4Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute for Inflammation and Repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK The Kellgren Centre for Rheumatology, Central Manchester Foundation Trust, NIHR Manchester Biomedical Research Centre, Manchester, UK. 5Monash University, Melbourne, Victoria, Australia. 6NIHR-Leeds Musculoskeletal Biomedical Research Unit, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK. 7Department of Clinical Medicine, Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland. 8Adelaide and Meath Hospital and Trinity College Dublin, Dublin, Ireland. 9Royal National Hospital for Rheumatic Diseases and Department Pharmacy and Pharmacology, University of Bath, Bath, UK. 10Department of Public Health and Clinical Medicine, Rheumatology, University Hospital, Umeå, Sweden. 11Department of Biopathology, Centre of Excellence for Genomic Risk Assessment in Multifactorial and Complex Diseases, School of Medicine, University of Rome 'Tor Vergata' and Fondazione PTV 'Policlinico Tor Vergata', Rome, Italy. 12Rheumatology Department, Haywood Hospital, Health Services Research Unit, Institute of Science and Technology in Medicine, Keele University. 13Department of Rheumatology, St. Vincent's University Hospital, UCD School of Medicine and Medical Sciences and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland. 14The University of Queensland Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, Woolloongabba, Brisbane, Queensland, Australia. 15Division of Rheumatology and Fraunhofer IME-Project-Group Translational Medicine and Pharmacology, Goethe University, Frankfurt, Germany. 16Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute for Inflammation and Repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK The Kellgren Centre for Rheumatology, Central Manchester Foundation Trust, NIHR Manchester Biomedical Research Centre, Manchester, UK.
Citation:
PTPN22 is associated with susceptibility to psoriatic arthritis but not psoriasis: evidence for a further PsA-specific risk locus. 2015: Ann. Rheum. Dis.
Publisher:
BMJ
Journal:
Annals of the rheumatic diseases
Issue Date:
28-Apr-2015
URI:
http://hdl.handle.net/10147/559093
DOI:
10.1136/annrheumdis-2014-207187
PubMed ID:
25923216
Abstract:
Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis; it has a higher estimated genetic component than psoriasis alone, however most genetic susceptibility loci identified for PsA to date are also shared with psoriasis. Here we attempt to validate novel single nucleotide polymorphisms selected from our recent PsA Immunochip study and determine specificity to PsA.
Item Type:
Report
Language:
en
Keywords:
GENETICS; ARTHRITIS
ISSN:
1468-2060

Full metadata record

DC FieldValue Language
dc.contributor.authorBowes, Johnen
dc.contributor.authorLoehr, Sabineen
dc.contributor.authorBudu-Aggrey, Ashleyen
dc.contributor.authorUebe, Steffenen
dc.contributor.authorBruce, Ian Nen
dc.contributor.authorFeletar, Marieen
dc.contributor.authorMarzo-Ortega, Helenaen
dc.contributor.authorHelliwell, Philipen
dc.contributor.authorRyan, Anthony Wen
dc.contributor.authorKane, Daviden
dc.contributor.authorKorendowych, Eleanoren
dc.contributor.authorAlenius, Gerd-Marieen
dc.contributor.authorGiardina, Emilianoen
dc.contributor.authorPackham, Jonathanen
dc.contributor.authorMcManus, Rossen
dc.contributor.authorFitzGerald, Oliveren
dc.contributor.authorBrown, Matthew Aen
dc.contributor.authorBehrens, Franken
dc.contributor.authorBurkhardt, Haralden
dc.contributor.authorMcHugh, Neilen
dc.contributor.authorHuffmeier, Ulrikeen
dc.contributor.authorHo, Paulineen
dc.contributor.authorReis, Andreen
dc.contributor.authorBarton, Anneen
dc.date.accessioned2015-07-07T08:56:32Zen
dc.date.available2015-07-07T08:56:32Zen
dc.date.issued2015-04-28en
dc.identifier.citationPTPN22 is associated with susceptibility to psoriatic arthritis but not psoriasis: evidence for a further PsA-specific risk locus. 2015: Ann. Rheum. Dis.en
dc.identifier.issn1468-2060en
dc.identifier.pmid25923216en
dc.identifier.doi10.1136/annrheumdis-2014-207187en
dc.identifier.urihttp://hdl.handle.net/10147/559093en
dc.description.abstractPsoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis; it has a higher estimated genetic component than psoriasis alone, however most genetic susceptibility loci identified for PsA to date are also shared with psoriasis. Here we attempt to validate novel single nucleotide polymorphisms selected from our recent PsA Immunochip study and determine specificity to PsA.en
dc.languageENGen
dc.language.isoenen
dc.publisherBMJen
dc.rightsArchived with thanks to Annals of the rheumatic diseasesen
dc.subjectGENETICSen
dc.subjectARTHRITISen
dc.titlePTPN22 is associated with susceptibility to psoriatic arthritis but not psoriasis: evidence for a further PsA-specific risk locus.en
dc.typeReporten
dc.contributor.department1Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute for Inflammation and Repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK. 2Institute of Human Genetics, University of Erlangen-Nuremberg, Erlangen, Germany. 3Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute for Inflammation and Repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK. 4Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute for Inflammation and Repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK The Kellgren Centre for Rheumatology, Central Manchester Foundation Trust, NIHR Manchester Biomedical Research Centre, Manchester, UK. 5Monash University, Melbourne, Victoria, Australia. 6NIHR-Leeds Musculoskeletal Biomedical Research Unit, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK. 7Department of Clinical Medicine, Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland. 8Adelaide and Meath Hospital and Trinity College Dublin, Dublin, Ireland. 9Royal National Hospital for Rheumatic Diseases and Department Pharmacy and Pharmacology, University of Bath, Bath, UK. 10Department of Public Health and Clinical Medicine, Rheumatology, University Hospital, Umeå, Sweden. 11Department of Biopathology, Centre of Excellence for Genomic Risk Assessment in Multifactorial and Complex Diseases, School of Medicine, University of Rome 'Tor Vergata' and Fondazione PTV 'Policlinico Tor Vergata', Rome, Italy. 12Rheumatology Department, Haywood Hospital, Health Services Research Unit, Institute of Science and Technology in Medicine, Keele University. 13Department of Rheumatology, St. Vincent's University Hospital, UCD School of Medicine and Medical Sciences and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland. 14The University of Queensland Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, Woolloongabba, Brisbane, Queensland, Australia. 15Division of Rheumatology and Fraunhofer IME-Project-Group Translational Medicine and Pharmacology, Goethe University, Frankfurt, Germany. 16Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute for Inflammation and Repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK The Kellgren Centre for Rheumatology, Central Manchester Foundation Trust, NIHR Manchester Biomedical Research Centre, Manchester, UK.en
dc.identifier.journalAnnals of the rheumatic diseasesen
dc.description.fundingNo fundingen
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen

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