A Multi-Center Prospective Derivation and Validation of a Clinical Prediction Tool for Severe Clostridium difficile Infection.

Hdl Handle:
http://hdl.handle.net/10147/559064
Title:
A Multi-Center Prospective Derivation and Validation of a Clinical Prediction Tool for Severe Clostridium difficile Infection.
Authors:
Na, Xi; Martin, Alan J; Sethi, Saurabh; Kyne, Lorraine; Garey, Kevin W; Flores, Sarah W; Hu, Mary; Shah, Dhara N; Shields, Kelsey; Leffler, Daniel A; Kelly, Ciarán P
Affiliation:
1Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America. 2Department of Medicine for the Older Person, Mater Misericordiae University Hospital and University College Dublin, Dublin, Ireland. 3University of Houston College of Pharmacy, Houston, Texas, United States of America.
Citation:
A Multi-Center Prospective Derivation and Validation of a Clinical Prediction Tool for Severe Clostridium difficile Infection. 2015, 10 (4):e0123405 PLoS ONE
Publisher:
Public Library of Science (PLoS One)
Journal:
PloS one
Issue Date:
23-Apr-2015
URI:
http://hdl.handle.net/10147/559064
DOI:
10.1371/journal.pone.0123405
PubMed ID:
25906284
Additional Links:
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123405
Abstract:
Prediction of severe clinical outcomes in Clostridium difficile infection (CDI) is important to inform management decisions for optimum patient care. Currently, treatment recommendations for CDI vary based on disease severity but validated methods to predict severe disease are lacking. The aim of the study was to derive and validate a clinical prediction tool for severe outcomes in CDI.
Item Type:
Article
Language:
en
Keywords:
INFECTION CONTROL; CLOSTRIDIUM DIFFICILE
ISSN:
1932-6203
Sponsors:
Funding: This work was funded in part by the following grants: NIH Awards DK-07760 (XN) and AI-95256 (CPK), Merck Investigator Studies Program (CPK and KWG), and Health Research Board Ireland CSA 2007/4 (LK and AJM). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Full metadata record

DC FieldValue Language
dc.contributor.authorNa, Xien
dc.contributor.authorMartin, Alan Jen
dc.contributor.authorSethi, Saurabhen
dc.contributor.authorKyne, Lorraineen
dc.contributor.authorGarey, Kevin Wen
dc.contributor.authorFlores, Sarah Wen
dc.contributor.authorHu, Maryen
dc.contributor.authorShah, Dhara Nen
dc.contributor.authorShields, Kelseyen
dc.contributor.authorLeffler, Daniel Aen
dc.contributor.authorKelly, Ciarán Pen
dc.date.accessioned2015-07-06T15:24:22Zen
dc.date.available2015-07-06T15:24:22Zen
dc.date.issued2015-04-23en
dc.identifier.citationA Multi-Center Prospective Derivation and Validation of a Clinical Prediction Tool for Severe Clostridium difficile Infection. 2015, 10 (4):e0123405 PLoS ONEen
dc.identifier.issn1932-6203en
dc.identifier.pmid25906284en
dc.identifier.doi10.1371/journal.pone.0123405en
dc.identifier.urihttp://hdl.handle.net/10147/559064en
dc.description.abstractPrediction of severe clinical outcomes in Clostridium difficile infection (CDI) is important to inform management decisions for optimum patient care. Currently, treatment recommendations for CDI vary based on disease severity but validated methods to predict severe disease are lacking. The aim of the study was to derive and validate a clinical prediction tool for severe outcomes in CDI.en
dc.description.sponsorshipFunding: This work was funded in part by the following grants: NIH Awards DK-07760 (XN) and AI-95256 (CPK), Merck Investigator Studies Program (CPK and KWG), and Health Research Board Ireland CSA 2007/4 (LK and AJM). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en
dc.language.isoenen
dc.publisherPublic Library of Science (PLoS One)en
dc.relation.urlhttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123405en
dc.rightsArchived with thanks to PloS oneen
dc.subjectINFECTION CONTROLen
dc.subjectCLOSTRIDIUM DIFFICILEen
dc.titleA Multi-Center Prospective Derivation and Validation of a Clinical Prediction Tool for Severe Clostridium difficile Infection.en
dc.typeArticleen
dc.contributor.department1Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America. 2Department of Medicine for the Older Person, Mater Misericordiae University Hospital and University College Dublin, Dublin, Ireland. 3University of Houston College of Pharmacy, Houston, Texas, United States of America.en
dc.identifier.journalPloS oneen
dc.description.fundingOtheren
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen

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