Fasting plasma glucose as initial screening for diabetes and prediabetes in irish adults: The Diabetes Mellitus and Vascular health initiative (DMVhi).

Hdl Handle:
http://hdl.handle.net/10147/559045
Title:
Fasting plasma glucose as initial screening for diabetes and prediabetes in irish adults: The Diabetes Mellitus and Vascular health initiative (DMVhi).
Authors:
Sinnott, M; Kinsley, BT; Jackson, AD; Walsh, C; O'Grady, T; Nolan, JJ; Gaffney, P; Boran, G; Kelleher, C; Carr, B
Affiliation:
1Vhi Healthcare Ltd, Dublin, Republic of Ireland. 2Mater Misericordiae University Hospital, Dublin, Republic of Ireland. 3Department of Statistics, Trinity College Dublin, Dublin, Republic of Ireland. 4Steno Diabetes Center, DK-2820 Gentofte, Denmark. 5The Adelaide and Meath Hospital incorporating the National Children's Hospital, Dublin, Republic of Ireland. 6University College Dublin School of Public Health, Physiotherapy and Population Science, University College Dublin, Dublin, Republic of Ireland. 7Vhi Healthcare Ltd, Dublin, Republic of Ireland; University College Dublin School of Public Health, Physiotherapy and Population Science, University College Dublin, Dublin, Republic of Ireland.
Citation:
Sinnott M, Kinsley BT, Jackson AD, Walsh C, O’Grady T, Nolan JJ, et al. (2015) Fasting Plasma Glucose as Initial Screening for Diabetes and Prediabetes in Irish Adults: The Diabetes Mellitus and Vascular Health Initiative (DMVhi). PLoS ONE 10(4): e0122704. doi:10.1371/journal.pone.0122704
Publisher:
Public Library of Science (PLoS One)
Journal:
PLOS ONE
Issue Date:
15-Apr-2015
URI:
http://hdl.handle.net/10147/559045
Additional Links:
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122704
Abstract:
Objective Type 2 diabetes has a long pre clinical asymptomatic phase. Early detection may delay or arrest disease progression. The Diabetes Mellitus and Vascular health initiative (DMVhi) was initiated as a prospective longitudinal cohort study on the prevalence of undiagnosed Type 2 diabetes and prediabetes, diabetes risk and cardiovascular risk in a cohort of Irish adults aged 45-75 years. Research Design and Methods Members of the largest Irish private health insurance provider aged 45 to 75 years were invited to participate in the study. Exclusion criteria: already diagnosed with diabetes or taking oral hypoglycaemic agents. Participants completed a detailed medical questionnaire, had weight, height, waist and hip circumference and blood pressure measured. Fasting blood samples were taken for fasting plasma glucose (FPG). Those with FPG in the impaired fasting glucose (IFG) range had a 75gm oral glucose tolerance test performed. Results 122,531 subjects were invited to participate. 29,144 (24%) completed the study. The prevalence of undiagnosed diabetes was 1.8%, of impaired fasting glucose (IFG) was 7.1% and of impaired glucose tolerance (IGT) was 2.9%. Dysglycaemia increased among those aged 45-54, 55-64 and 65-75 years in both males (10.6%, 18.5%, 21.7% respectively) and females (4.3%, 8.6%, 10.9% respectively). Undiagnosed T2D, IFG and IGT were all associated with gender, age, blood pressure, BMI, abdominal obesity, family history of diabetes and triglyceride levels. Using FPG as initial screening may underestimate the prevalence of T2D in the study population. Conclusions This study is the largest screening study for diabetes and prediabetes in the Irish population. Follow up of this cohort will provide data on progression to diabetes and on cardiovascular outcomes.
Item Type:
Article
Language:
en
Keywords:
DIABETES; SCREENING
Sponsors:
Funder:DMVhi research project was funded by Vhi Healthcare. Part funding was received for the project through the EU-funded DEXLIFE ressearch program. Vhi Healthcare Ltd., provided support in the form of salaries for authors MS, ADJ, TOG & BC, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section.

Full metadata record

DC FieldValue Language
dc.contributor.authorSinnott, Men
dc.contributor.authorKinsley, BTen
dc.contributor.authorJackson, ADen
dc.contributor.authorWalsh, Cen
dc.contributor.authorO'Grady, Ten
dc.contributor.authorNolan, JJen
dc.contributor.authorGaffney, Pen
dc.contributor.authorBoran, Gen
dc.contributor.authorKelleher, Cen
dc.contributor.authorCarr, Ben
dc.date.accessioned2015-07-06T14:36:34Zen
dc.date.available2015-07-06T14:36:34Zen
dc.date.issued2015-04-15en
dc.identifier.citationSinnott M, Kinsley BT, Jackson AD, Walsh C, O’Grady T, Nolan JJ, et al. (2015) Fasting Plasma Glucose as Initial Screening for Diabetes and Prediabetes in Irish Adults: The Diabetes Mellitus and Vascular Health Initiative (DMVhi). PLoS ONE 10(4): e0122704. doi:10.1371/journal.pone.0122704en
dc.identifier.urihttp://hdl.handle.net/10147/559045en
dc.description.abstractObjective Type 2 diabetes has a long pre clinical asymptomatic phase. Early detection may delay or arrest disease progression. The Diabetes Mellitus and Vascular health initiative (DMVhi) was initiated as a prospective longitudinal cohort study on the prevalence of undiagnosed Type 2 diabetes and prediabetes, diabetes risk and cardiovascular risk in a cohort of Irish adults aged 45-75 years. Research Design and Methods Members of the largest Irish private health insurance provider aged 45 to 75 years were invited to participate in the study. Exclusion criteria: already diagnosed with diabetes or taking oral hypoglycaemic agents. Participants completed a detailed medical questionnaire, had weight, height, waist and hip circumference and blood pressure measured. Fasting blood samples were taken for fasting plasma glucose (FPG). Those with FPG in the impaired fasting glucose (IFG) range had a 75gm oral glucose tolerance test performed. Results 122,531 subjects were invited to participate. 29,144 (24%) completed the study. The prevalence of undiagnosed diabetes was 1.8%, of impaired fasting glucose (IFG) was 7.1% and of impaired glucose tolerance (IGT) was 2.9%. Dysglycaemia increased among those aged 45-54, 55-64 and 65-75 years in both males (10.6%, 18.5%, 21.7% respectively) and females (4.3%, 8.6%, 10.9% respectively). Undiagnosed T2D, IFG and IGT were all associated with gender, age, blood pressure, BMI, abdominal obesity, family history of diabetes and triglyceride levels. Using FPG as initial screening may underestimate the prevalence of T2D in the study population. Conclusions This study is the largest screening study for diabetes and prediabetes in the Irish population. Follow up of this cohort will provide data on progression to diabetes and on cardiovascular outcomes.en
dc.description.sponsorshipFunder:DMVhi research project was funded by Vhi Healthcare. Part funding was received for the project through the EU-funded DEXLIFE ressearch program. Vhi Healthcare Ltd., provided support in the form of salaries for authors MS, ADJ, TOG & BC, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section.en
dc.language.isoenen
dc.publisherPublic Library of Science (PLoS One)en
dc.relation.urlhttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122704en
dc.subjectDIABETESen
dc.subjectSCREENINGen
dc.titleFasting plasma glucose as initial screening for diabetes and prediabetes in irish adults: The Diabetes Mellitus and Vascular health initiative (DMVhi).en
dc.typeArticleen
dc.contributor.department1Vhi Healthcare Ltd, Dublin, Republic of Ireland. 2Mater Misericordiae University Hospital, Dublin, Republic of Ireland. 3Department of Statistics, Trinity College Dublin, Dublin, Republic of Ireland. 4Steno Diabetes Center, DK-2820 Gentofte, Denmark. 5The Adelaide and Meath Hospital incorporating the National Children's Hospital, Dublin, Republic of Ireland. 6University College Dublin School of Public Health, Physiotherapy and Population Science, University College Dublin, Dublin, Republic of Ireland. 7Vhi Healthcare Ltd, Dublin, Republic of Ireland; University College Dublin School of Public Health, Physiotherapy and Population Science, University College Dublin, Dublin, Republic of Ireland.en
dc.identifier.journalPLOS ONEen
dc.description.fundingOtheren
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen
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