HLA testing for coeliac disease in Ireland?

Hdl Handle:
http://hdl.handle.net/10147/559034
Title:
HLA testing for coeliac disease in Ireland?
Authors:
Kutty, J; Hussey, S; Broderick, AM; Quinn, S; Bourke, B
Publisher:
Irish Medical Journal
Journal:
Irish Medical Journal
Issue Date:
May-2015
URI:
http://hdl.handle.net/10147/559034
Abstract:
Recent studies have shown a worldwide prevalence of coeliac disease (CD) of around 1% and one of the highest prevalence rates (1 in 300) has been found in the West of Ireland. 1,2 The incidence of coeliac disease appears to be increasing. For example, a greater than 6-fold increase over a 20 year period was evident in a recent retrospective Scottish study. 3 Children with selective IgA deficiency, Down syndrome, Type I diabetes mellitus and autoimmune diseases are at increased risk of CD. Those with a family history are particularly vulnerable with as many as 1 in 10 first-degree, and 1 in 40 second-degree relatives affected. 1 The presenting features of coeliac disease are heterogeneous. The most commonly described symptoms include diarrhoea, excessive flatulence, weight loss, failure to thrive, abdominal distension, pain, bloating, vomiting and anorexia. Irritability is a particularly consistent finding in symptomatic coeliac disease in childhood and CD can also present with many other systemic symptoms such as iron deficiency, anaemia, fatigue, short stature, abnormal liver enzyme tests, osteopenia and dermatitis herpetiformis. However, it must also be remembered that the vast majority of affected individuals manifest few or no symptoms at all
Item Type:
Article
Language:
en
Keywords:
GLUTEN; INTESTINE
Local subject classification:
ALLGERIES

Full metadata record

DC FieldValue Language
dc.contributor.authorKutty, Jen
dc.contributor.authorHussey, Sen
dc.contributor.authorBroderick, AMen
dc.contributor.authorQuinn, Sen
dc.contributor.authorBourke, Ben
dc.date.accessioned2015-07-06T13:27:12Zen
dc.date.available2015-07-06T13:27:12Zen
dc.date.issued2015-05en
dc.identifier.urihttp://hdl.handle.net/10147/559034en
dc.description.abstractRecent studies have shown a worldwide prevalence of coeliac disease (CD) of around 1% and one of the highest prevalence rates (1 in 300) has been found in the West of Ireland. 1,2 The incidence of coeliac disease appears to be increasing. For example, a greater than 6-fold increase over a 20 year period was evident in a recent retrospective Scottish study. 3 Children with selective IgA deficiency, Down syndrome, Type I diabetes mellitus and autoimmune diseases are at increased risk of CD. Those with a family history are particularly vulnerable with as many as 1 in 10 first-degree, and 1 in 40 second-degree relatives affected. 1 The presenting features of coeliac disease are heterogeneous. The most commonly described symptoms include diarrhoea, excessive flatulence, weight loss, failure to thrive, abdominal distension, pain, bloating, vomiting and anorexia. Irritability is a particularly consistent finding in symptomatic coeliac disease in childhood and CD can also present with many other systemic symptoms such as iron deficiency, anaemia, fatigue, short stature, abnormal liver enzyme tests, osteopenia and dermatitis herpetiformis. However, it must also be remembered that the vast majority of affected individuals manifest few or no symptoms at allen
dc.languageenen
dc.language.isoenen
dc.publisherIrish Medical Journalen
dc.subjectGLUTENen
dc.subjectINTESTINEen
dc.subject.otherALLGERIESen
dc.titleHLA testing for coeliac disease in Ireland?en
dc.typeArticleen
dc.identifier.journalIrish Medical Journalen
dc.description.fundingNo fundingen
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen
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