Antibiotic prophylaxis in children with vesicoureteric reflux: has RIVUR answered all our questions?

Hdl Handle:
http://hdl.handle.net/10147/559025
Title:
Antibiotic prophylaxis in children with vesicoureteric reflux: has RIVUR answered all our questions?
Authors:
Teoh, CW; Awan, A
Publisher:
Irish Medical Journal
Journal:
Irish Medical Journal
Issue Date:
Apr-2015
URI:
http://hdl.handle.net/10147/559025
Abstract:
The interest in urinary tract infections (UTI) and vesicoureteral reflux (VUR), which is the retrograde flow of urine from the bladder into the ureter, started gaining pace in the late 1950s after the introduction of voiding cystourethrography. 1 VUR is present in one third of children presenting with febrile urinary tract infections (UTI) and is associated with renal scarring. 1 In an effort to reduce renal scarring as a result of VUR, various surgical repairs of the vesicoureteral junction, and later endoscopic injection techniques were introduced. 2 With the emerging understanding of the strong association between UTI and VUR, antibiotic prophylaxis gained popularity after an observational study showed that VUR improved with long-term, low-dose antibiotic treatment. 3 Smellie et al found that prophylaxis significantly reduced the number of UTI recurrences compared to before prophylaxis. 4 The use of antibiotic prophylaxis became standard practice after two large prospective randomised trials comparing surgical intervention and antibiotic prophylaxis found no difference between the two interventions in relation to UTI recurrence and new renal damage. 5-7 Endoscopic and surgical treatments were reserved for severe reflux.
Item Type:
Article
Language:
en
Keywords:
URINARY TRACT DISEASE; ANTIBIOTICS
Local subject classification:
CHILDREN

Full metadata record

DC FieldValue Language
dc.contributor.authorTeoh, CWen
dc.contributor.authorAwan, Aen
dc.date.accessioned2015-07-06T11:52:04Zen
dc.date.available2015-07-06T11:52:04Zen
dc.date.issued2015-04en
dc.identifier.urihttp://hdl.handle.net/10147/559025en
dc.description.abstractThe interest in urinary tract infections (UTI) and vesicoureteral reflux (VUR), which is the retrograde flow of urine from the bladder into the ureter, started gaining pace in the late 1950s after the introduction of voiding cystourethrography. 1 VUR is present in one third of children presenting with febrile urinary tract infections (UTI) and is associated with renal scarring. 1 In an effort to reduce renal scarring as a result of VUR, various surgical repairs of the vesicoureteral junction, and later endoscopic injection techniques were introduced. 2 With the emerging understanding of the strong association between UTI and VUR, antibiotic prophylaxis gained popularity after an observational study showed that VUR improved with long-term, low-dose antibiotic treatment. 3 Smellie et al found that prophylaxis significantly reduced the number of UTI recurrences compared to before prophylaxis. 4 The use of antibiotic prophylaxis became standard practice after two large prospective randomised trials comparing surgical intervention and antibiotic prophylaxis found no difference between the two interventions in relation to UTI recurrence and new renal damage. 5-7 Endoscopic and surgical treatments were reserved for severe reflux.en
dc.language.isoenen
dc.publisherIrish Medical Journalen
dc.subjectURINARY TRACT DISEASEen
dc.subjectANTIBIOTICSen
dc.subject.otherCHILDRENen
dc.titleAntibiotic prophylaxis in children with vesicoureteric reflux: has RIVUR answered all our questions?en
dc.typeArticleen
dc.identifier.journalIrish Medical Journalen
dc.description.fundingNo fundingen
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen
All Items in Lenus, The Irish Health Repository are protected by copyright, with all rights reserved, unless otherwise indicated.