The contribution of Ebola viral load at admission and other patient characteristics to mortality in a Médecins Sans Frontières (MSF) Ebola Case Management Centre (CMC), Kailahun, Sierra Leone, June -October, 2014.

Hdl Handle:
http://hdl.handle.net/10147/556171
Title:
The contribution of Ebola viral load at admission and other patient characteristics to mortality in a Médecins Sans Frontières (MSF) Ebola Case Management Centre (CMC), Kailahun, Sierra Leone, June -October, 2014.
Authors:
Fitzpatrick, Gabriel; Vogt, Florian; Gbabai, Osman B Moi; Decroo, Tom; Keane, Marian; De Clerck, Hilde; Grolla, Allen; Brechard, Raphael; Stinson, Kathryn; Van Herp, Michel
Citation:
The contribution of Ebola viral load at admission and other patient characteristics to mortality in a Médecins Sans Frontières (MSF) Ebola Case Management Centre (CMC), Kailahun, Sierra Leone, June -October, 2014. 2015: J. Infect. Dis.
Publisher:
Oxford University Press
Journal:
The Journal of infectious diseases
Issue Date:
22-May-2015
URI:
http://hdl.handle.net/10147/556171
DOI:
10.1093/infdis/jiv304
PubMed ID:
26002981
Abstract:
This paper describes patient characteristics, including Ebola viral load, associated with mortality in an MSF Ebola case management centre. Out of 780 admissions between June and October 2014, 525 (67%) were positive for Ebola with a known outcome. The crude mortality rate was 51% (270/525). Ebola viral load (whole blood sample) data was available on 76% (397/525) of patients. Univariate analysis indicated viral load at admission, age, symptom duration prior to admission and distance travelled to the CMC were associated with mortality (p value<0.05). The multivariable model predicted mortality in those with a viral load at admission greater than 10 million copies per millilitre (p value<0.05, Odds Ratio>10), aged 50 years or more (p value=0.08, Odds Ratio=2) and symptom duration prior to admission less than 5 days (p value=0.14). The presence of confusion, diarrhoea and conjunctivitis were significantly higher (p value<0.05) in Ebola patients who died. These findings highlight the importance viral load at admission has on mortality outcomes and could be used to cohort cases with viral loads greater than 10 million copies into dedicated wards with more intensive medical support to further reduce mortality.
Item Type:
Article In Press
Language:
en
Keywords:
INFECTION CONTROL; INFECTIOUS DISEASE
Local subject classification:
EBOLA VIRUS
ISSN:
1537-6613
Sponsors:
No funding was obtained.

Full metadata record

DC FieldValue Language
dc.contributor.authorFitzpatrick, Gabrielen
dc.contributor.authorVogt, Florianen
dc.contributor.authorGbabai, Osman B Moien
dc.contributor.authorDecroo, Tomen
dc.contributor.authorKeane, Marianen
dc.contributor.authorDe Clerck, Hildeen
dc.contributor.authorGrolla, Allenen
dc.contributor.authorBrechard, Raphaelen
dc.contributor.authorStinson, Kathrynen
dc.contributor.authorVan Herp, Michelen
dc.date.accessioned2015-06-02T14:57:22Zen
dc.date.available2015-06-02T14:57:22Zen
dc.date.issued2015-05-22en
dc.identifier.citationThe contribution of Ebola viral load at admission and other patient characteristics to mortality in a Médecins Sans Frontières (MSF) Ebola Case Management Centre (CMC), Kailahun, Sierra Leone, June -October, 2014. 2015: J. Infect. Dis.en
dc.identifier.issn1537-6613en
dc.identifier.pmid26002981en
dc.identifier.doi10.1093/infdis/jiv304en
dc.identifier.urihttp://hdl.handle.net/10147/556171en
dc.description.abstractThis paper describes patient characteristics, including Ebola viral load, associated with mortality in an MSF Ebola case management centre. Out of 780 admissions between June and October 2014, 525 (67%) were positive for Ebola with a known outcome. The crude mortality rate was 51% (270/525). Ebola viral load (whole blood sample) data was available on 76% (397/525) of patients. Univariate analysis indicated viral load at admission, age, symptom duration prior to admission and distance travelled to the CMC were associated with mortality (p value<0.05). The multivariable model predicted mortality in those with a viral load at admission greater than 10 million copies per millilitre (p value<0.05, Odds Ratio>10), aged 50 years or more (p value=0.08, Odds Ratio=2) and symptom duration prior to admission less than 5 days (p value=0.14). The presence of confusion, diarrhoea and conjunctivitis were significantly higher (p value<0.05) in Ebola patients who died. These findings highlight the importance viral load at admission has on mortality outcomes and could be used to cohort cases with viral loads greater than 10 million copies into dedicated wards with more intensive medical support to further reduce mortality.en
dc.description.sponsorshipNo funding was obtained.en
dc.languageENGen
dc.language.isoenen
dc.publisherOxford University Pressen
dc.rightsArchived with thanks to The Journal of infectious diseasesen
dc.subjectINFECTION CONTROLen
dc.subjectINFECTIOUS DISEASEen
dc.subject.otherEBOLA VIRUSen
dc.titleThe contribution of Ebola viral load at admission and other patient characteristics to mortality in a Médecins Sans Frontières (MSF) Ebola Case Management Centre (CMC), Kailahun, Sierra Leone, June -October, 2014.en
dc.typeArticle In Pressen
dc.identifier.journalThe Journal of infectious diseasesen

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