Altered hemodynamics and hyperuricemia accompany an elevated sFlt-1/PlGF ratio before the onset of early severe preeclampsia.

Hdl Handle:
http://hdl.handle.net/10147/346521
Title:
Altered hemodynamics and hyperuricemia accompany an elevated sFlt-1/PlGF ratio before the onset of early severe preeclampsia.
Authors:
Doherty, Anne; Carvalho, Jose C A; Drewlo, Sascha; El-Khuffash, Afif; Downey, Kristi; Dodds, Madelaine; Kingdom, John
Affiliation:
Department of Anesthesia, Mount Sinai Hospital, University of Toronto, Toronto ON.
Citation:
Doherty, A. et al., 2014. Altered hemodynamics and hyperuricemia accompany an elevated sFlt-1/PlGF ratio before the onset of early severe preeclampsia. Journal of Obstetrics and Gynaecology Canada, 36 (8):692-700
Journal:
Journal of Obstetrics and Gynaecology Canada : JOGC - Journal d'obstétrique et gynécologie du Canada : JOGC
Issue Date:
Aug-2014
URI:
http://hdl.handle.net/10147/346521
PubMed ID:
25222164
Abstract:
Early identification of women at risk of developing early-onset severe preeclampsia (sPE) is a key objective in obstetrics. An elevated ratio of serum soluble fms-like tyrosine kinase (sFlt-1) to placenta-like growth factor (PlGF) (sFlt-1/PlGF ratio) precedes overt hypertension. The longitudinal relationship between this biomarker, maternal hemodynamics, and maternal serum uric acid during the pre-clinical phase is unknown.
Item Type:
Article
Language:
en
Keywords:
PREGNANCY
Local subject classification:
PRE-ECLAMPSIA; HYPERURICEMIA
MeSH:
Biological Markers; Cohort Studies; Female; Hemodynamics; Humans; Hyperuricemia; Pre-Eclampsia; Pregnancy; Pregnancy Proteins; Vascular Endothelial Growth Factor Receptor-1
ISSN:
1701-2163

Full metadata record

DC FieldValue Language
dc.contributor.authorDoherty, Anneen
dc.contributor.authorCarvalho, Jose C Aen
dc.contributor.authorDrewlo, Saschaen
dc.contributor.authorEl-Khuffash, Afifen
dc.contributor.authorDowney, Kristien
dc.contributor.authorDodds, Madelaineen
dc.contributor.authorKingdom, Johnen
dc.date.accessioned2015-03-11T10:17:57Zen
dc.date.available2015-03-11T10:17:57Zen
dc.date.issued2014-08en
dc.identifier.citationDoherty, A. et al., 2014. Altered hemodynamics and hyperuricemia accompany an elevated sFlt-1/PlGF ratio before the onset of early severe preeclampsia. Journal of Obstetrics and Gynaecology Canada, 36 (8):692-700en
dc.identifier.issn1701-2163en
dc.identifier.pmid25222164en
dc.identifier.urihttp://hdl.handle.net/10147/346521en
dc.description.abstractEarly identification of women at risk of developing early-onset severe preeclampsia (sPE) is a key objective in obstetrics. An elevated ratio of serum soluble fms-like tyrosine kinase (sFlt-1) to placenta-like growth factor (PlGF) (sFlt-1/PlGF ratio) precedes overt hypertension. The longitudinal relationship between this biomarker, maternal hemodynamics, and maternal serum uric acid during the pre-clinical phase is unknown.en
dc.language.isoenen
dc.rightsArchived with thanks to Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstétrique et gynécologie du Canada : JOGCen_GB
dc.subjectPREGNANCYen
dc.subject.meshBiological Markers-
dc.subject.meshCohort Studies-
dc.subject.meshFemale-
dc.subject.meshHemodynamics-
dc.subject.meshHumans-
dc.subject.meshHyperuricemia-
dc.subject.meshPre-Eclampsia-
dc.subject.meshPregnancy-
dc.subject.meshPregnancy Proteins-
dc.subject.meshVascular Endothelial Growth Factor Receptor-1-
dc.subject.otherPRE-ECLAMPSIAen
dc.subject.otherHYPERURICEMIAen
dc.titleAltered hemodynamics and hyperuricemia accompany an elevated sFlt-1/PlGF ratio before the onset of early severe preeclampsia.en
dc.typeArticleen
dc.contributor.departmentDepartment of Anesthesia, Mount Sinai Hospital, University of Toronto, Toronto ON.en
dc.identifier.journalJournal of Obstetrics and Gynaecology Canada : JOGC - Journal d'obstétrique et gynécologie du Canada : JOGCen
dc.description.fundingOtheren
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen

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