Vitamin D as an adjunctive therapy in asthma. Part 1: A review of potential mechanisms.

Hdl Handle:
http://hdl.handle.net/10147/346452
Title:
Vitamin D as an adjunctive therapy in asthma. Part 1: A review of potential mechanisms.
Authors:
Kerley, Conor P; Elnazir, Basil; Faul, John; Cormican, Liam
Citation:
Kerley, C.P et al., 2015. Vitamin D as an adjunctive therapy in asthma. Part 1: A review of potential mechanisms. Pulmonary pharmacology & therapeutics 2015 Feb 28 [epub ahead of print].
Journal:
Pulmonary pharmacology & therapeutics
Issue Date:
27-Feb-2015
URI:
http://hdl.handle.net/10147/346452
DOI:
10.1016/j.pupt.2015.02.004
PubMed ID:
25732539
Abstract:
Vitamin D deficiency (VDD) is highly prevlalent worldwide. The classical role for vitamin D is to regulate calcium absorption form the gastrointestinal tract and influence bone health. Recently vitamin D receptors and vitamin D metabolic enzymes have been discovered in numerous sites systemically supporting diverse extra-skeletal roles of vitamin D, for example in asthmatic disease. Further, VDD and asthma share several common risk factors including high latitude, winter season, industrialization, poor diet, obesity, and dark skin pigmentation. Vitamin D has been demonstrated to possess potent immunomodulatory effects, including effects on T cells and B cells as well as increasing production of antimicrobial peptides (e.g. cathelicidin). This immunomodulation may lead to asthma specific clinical benefits in terms of decreased bacterial/viral infections, altered airway smooth muscle-remodeling and -function as well as modulation of response to standard anti-asthma therapy (e.g. glucocorticoids and immunotherapy). Thus, vitamin D and its deficiency have a number of biological effects that are potentially important in altering the course of disease pathogenesis and severity in asthma. The purpose of this first of a two-part review is to review potential mechanisms whereby altering vitamin D status may influence asthmatic disease.
Language:
en
ISSN:
1522-9629

Full metadata record

DC FieldValue Language
dc.contributor.authorKerley, Conor Pen
dc.contributor.authorElnazir, Basilen
dc.contributor.authorFaul, Johnen
dc.contributor.authorCormican, Liamen
dc.date.accessioned2015-03-10T10:01:05Zen
dc.date.available2015-03-10T10:01:05Zen
dc.date.issued2015-02-27en
dc.identifier.citationKerley, C.P et al., 2015. Vitamin D as an adjunctive therapy in asthma. Part 1: A review of potential mechanisms. Pulmonary pharmacology & therapeutics 2015 Feb 28 [epub ahead of print].en
dc.identifier.issn1522-9629en
dc.identifier.pmid25732539en
dc.identifier.doi10.1016/j.pupt.2015.02.004en
dc.identifier.urihttp://hdl.handle.net/10147/346452en
dc.description.abstractVitamin D deficiency (VDD) is highly prevlalent worldwide. The classical role for vitamin D is to regulate calcium absorption form the gastrointestinal tract and influence bone health. Recently vitamin D receptors and vitamin D metabolic enzymes have been discovered in numerous sites systemically supporting diverse extra-skeletal roles of vitamin D, for example in asthmatic disease. Further, VDD and asthma share several common risk factors including high latitude, winter season, industrialization, poor diet, obesity, and dark skin pigmentation. Vitamin D has been demonstrated to possess potent immunomodulatory effects, including effects on T cells and B cells as well as increasing production of antimicrobial peptides (e.g. cathelicidin). This immunomodulation may lead to asthma specific clinical benefits in terms of decreased bacterial/viral infections, altered airway smooth muscle-remodeling and -function as well as modulation of response to standard anti-asthma therapy (e.g. glucocorticoids and immunotherapy). Thus, vitamin D and its deficiency have a number of biological effects that are potentially important in altering the course of disease pathogenesis and severity in asthma. The purpose of this first of a two-part review is to review potential mechanisms whereby altering vitamin D status may influence asthmatic disease.en
dc.languageENGen
dc.language.isoenen
dc.rightsArchived with thanks to Pulmonary pharmacology & therapeuticsen
dc.titleVitamin D as an adjunctive therapy in asthma. Part 1: A review of potential mechanisms.en
dc.identifier.journalPulmonary pharmacology & therapeuticsen
dc.description.fundingOtheren
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen

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