The antimicrobial activity of prototype modified honeys that generate reactive oxygen species (ROS) hydrogen peroxide

Hdl Handle:
http://hdl.handle.net/10147/346202
Title:
The antimicrobial activity of prototype modified honeys that generate reactive oxygen species (ROS) hydrogen peroxide
Authors:
Cooke, Jonathan; Dryden, Matthew; Patton, Thomas; Brennan, James; Barrett, John
Citation:
Cooke, J. et al., 2015. The antimicrobial activity of prototype modified honeys that generate reactive oxygen species (ROS) hydrogen peroxide. BMC Research Notes. 2015 Jan 28;8(1):20
Issue Date:
28-Jan-2015
URI:
http://dx.doi.org/10.1186/s13104-014-0960-4; http://hdl.handle.net/10147/346202
Abstract:
Abstract Background Antimicrobial resistance continues to be a global issue in healthcare organisations. Honey has long been shown to possess wound healing and antimicrobial properties that are dependent on a number of physical and chemical properties of the honey. We tested the antimicrobial activity of a medicinal honey, Surgihoney® (SH) and two prototype modified honeys made by Apis mellifera (honeybee) against Staphylococcus aureus (NCIMB 9518). We also examined the modified honey prototypes for the ability to generate reactive oxygen species (ROS) by changing the level of production of hydrogen peroxide from the samples. Methods Surgihoney® (SH) was compared with two modified honeys, Prototype 1 (PT1) and Prototype 2 (PT2) using a bioassay method against a standard strain of Staphylococcus aureus. Further work studied the rate of generation of ROS hydrogen peroxide from these preparations. Results Surgihoney® antimicrobial activity was shown to be largely due to ROS hydrogen peroxide production. By modification of Surgihoney®, two more potent honey prototypes were shown to generate between a two- and three-fold greater antibacterial activity and up to ten times greater ROS peroxide activity. Conclusions Surgihoney® is a clinically available wound antiseptic dressing that shows good antimicrobial activity. Two further honey prototypes have been shown to have antimicrobial activity that is possible to be enhanced due to demonstrated increases in ROS peroxide activity.
Language:
en
Keywords:
FOOD; NUTRITION
Local subject classification:
MICROBIOLOGY

Full metadata record

DC FieldValue Language
dc.contributor.authorCooke, Jonathanen
dc.contributor.authorDryden, Matthewen
dc.contributor.authorPatton, Thomasen
dc.contributor.authorBrennan, Jamesen
dc.contributor.authorBarrett, Johnen
dc.date.accessioned2015-03-05T11:54:41Zen
dc.date.available2015-03-05T11:54:41Zen
dc.date.issued2015-01-28en
dc.identifier.citationCooke, J. et al., 2015. The antimicrobial activity of prototype modified honeys that generate reactive oxygen species (ROS) hydrogen peroxide. BMC Research Notes. 2015 Jan 28;8(1):20en
dc.identifier.urihttp://dx.doi.org/10.1186/s13104-014-0960-4en
dc.identifier.urihttp://hdl.handle.net/10147/346202en
dc.description.abstractAbstract Background Antimicrobial resistance continues to be a global issue in healthcare organisations. Honey has long been shown to possess wound healing and antimicrobial properties that are dependent on a number of physical and chemical properties of the honey. We tested the antimicrobial activity of a medicinal honey, Surgihoney® (SH) and two prototype modified honeys made by Apis mellifera (honeybee) against Staphylococcus aureus (NCIMB 9518). We also examined the modified honey prototypes for the ability to generate reactive oxygen species (ROS) by changing the level of production of hydrogen peroxide from the samples. Methods Surgihoney® (SH) was compared with two modified honeys, Prototype 1 (PT1) and Prototype 2 (PT2) using a bioassay method against a standard strain of Staphylococcus aureus. Further work studied the rate of generation of ROS hydrogen peroxide from these preparations. Results Surgihoney® antimicrobial activity was shown to be largely due to ROS hydrogen peroxide production. By modification of Surgihoney®, two more potent honey prototypes were shown to generate between a two- and three-fold greater antibacterial activity and up to ten times greater ROS peroxide activity. Conclusions Surgihoney® is a clinically available wound antiseptic dressing that shows good antimicrobial activity. Two further honey prototypes have been shown to have antimicrobial activity that is possible to be enhanced due to demonstrated increases in ROS peroxide activity.-
dc.language.isoenen
dc.subjectFOODen
dc.subjectNUTRITIONen
dc.subject.otherMICROBIOLOGYen
dc.titleThe antimicrobial activity of prototype modified honeys that generate reactive oxygen species (ROS) hydrogen peroxideen
dc.language.rfc3066en-
dc.rights.holderJonathan Cooke et al.; licensee BioMed Central Ltd.-
dc.description.statusPeer Reviewed-
dc.date.updated2015-01-30T20:03:15Z-
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