Catecholamine-resistant hypotension and myocardial performance following patent ductus arteriosus ligation.

Hdl Handle:
http://hdl.handle.net/10147/345412
Title:
Catecholamine-resistant hypotension and myocardial performance following patent ductus arteriosus ligation.
Authors:
Noori, S; McNamara, P; Jain, A; Lavoie, P M; Wickremasinghe, A; Merritt, T A; Solomon, T; Sekar, K; Attridge, J T; Swanson, J R; Gillam-Krakauer, M; Reese, J; Poindexter, B B; Brook, M; Auchus, R J; Clyman, R I
Affiliation:
1] Department of Pediatrics, Children's Hospital of Los Angeles, University of South California, Los Angeles, CA, USA [2] Department of Pediatrics, University of Oklahoma, Oklahoma, OK, USA.
Citation:
Noori, S. et al., 2014. Catecholamine-resistant hypotension and myocardial performance following patent ductus arteriosus ligation. Journal of Perinatology, 2014 [ Epub 2014 Aug 14]
Journal:
Journal of Perinatology : official journal of the California Perinatal Association
Issue Date:
14-Aug-2014
URI:
http://hdl.handle.net/10147/345412
DOI:
10.1038/jp.2014.151
PubMed ID:
25118721
Abstract:
Objective:We performed a multicenter study of preterm infants, who were about to undergo patent ductus arteriosus ligation, to determine whether echocardiographic indices of impaired myocardial performance were associated with subsequent development of catecholamine-resistant hypotension following ligation.Study Design:A standardized treatment approach for hypotension was followed at each center. Infants were considered to have catecholamine-resistant hypotension if their dopamine infusion was >15 μg kg(-1)min(-1). Echocardiograms and cortisol measurements were obtained between 6 and 14 h after the ligation (prior to the presence of catecholamine-resistant hypotension).Result:Forty-five infants were enrolled, 10 received catecholamines (6 were catecholamine-responsive and 4 developed catecholamine-resistant hypotension). Catecholamine-resistant hypotension was not associated with decreased preload, shortening fraction or ventricular output. Infants with catecholamine-resistant hypotension had significantly lower levels of systemic vascular resistance and postoperative cortisol concentration.Conclusion:We speculate that low cortisol levels and impaired vascular tone may have a more important role than impaired cardiac performance in post-ligation catecholamine-resistant hypotension.Journal of Perinatology advance online publication, 14 August 2014; doi:10.1038/jp.2014.151.
Item Type:
Article
Language:
en
Keywords:
NEONATE
Local subject classification:
HEART
ISSN:
1476-5543

Full metadata record

DC FieldValue Language
dc.contributor.authorNoori, Sen
dc.contributor.authorMcNamara, Pen
dc.contributor.authorJain, Aen
dc.contributor.authorLavoie, P Men
dc.contributor.authorWickremasinghe, Aen
dc.contributor.authorMerritt, T Aen
dc.contributor.authorSolomon, Ten
dc.contributor.authorSekar, Ken
dc.contributor.authorAttridge, J Ten
dc.contributor.authorSwanson, J Ren
dc.contributor.authorGillam-Krakauer, Men
dc.contributor.authorReese, Jen
dc.contributor.authorPoindexter, B Ben
dc.contributor.authorBrook, Men
dc.contributor.authorAuchus, R Jen
dc.contributor.authorClyman, R Ien
dc.date.accessioned2015-02-26T13:07:53Zen
dc.date.available2015-02-26T13:07:53Zen
dc.date.issued2014-08-14en
dc.identifier.citationNoori, S. et al., 2014. Catecholamine-resistant hypotension and myocardial performance following patent ductus arteriosus ligation. Journal of Perinatology, 2014 [ Epub 2014 Aug 14]en
dc.identifier.issn1476-5543en
dc.identifier.pmid25118721en
dc.identifier.doi10.1038/jp.2014.151en
dc.identifier.urihttp://hdl.handle.net/10147/345412en
dc.description.abstractObjective:We performed a multicenter study of preterm infants, who were about to undergo patent ductus arteriosus ligation, to determine whether echocardiographic indices of impaired myocardial performance were associated with subsequent development of catecholamine-resistant hypotension following ligation.Study Design:A standardized treatment approach for hypotension was followed at each center. Infants were considered to have catecholamine-resistant hypotension if their dopamine infusion was >15 μg kg(-1)min(-1). Echocardiograms and cortisol measurements were obtained between 6 and 14 h after the ligation (prior to the presence of catecholamine-resistant hypotension).Result:Forty-five infants were enrolled, 10 received catecholamines (6 were catecholamine-responsive and 4 developed catecholamine-resistant hypotension). Catecholamine-resistant hypotension was not associated with decreased preload, shortening fraction or ventricular output. Infants with catecholamine-resistant hypotension had significantly lower levels of systemic vascular resistance and postoperative cortisol concentration.Conclusion:We speculate that low cortisol levels and impaired vascular tone may have a more important role than impaired cardiac performance in post-ligation catecholamine-resistant hypotension.Journal of Perinatology advance online publication, 14 August 2014; doi:10.1038/jp.2014.151.en
dc.languageENG-
dc.language.isoenen
dc.rightsArchived with thanks to Journal of perinatology : official journal of the California Perinatal Associationen_GB
dc.subjectNEONATEen
dc.subject.otherHEARTen
dc.titleCatecholamine-resistant hypotension and myocardial performance following patent ductus arteriosus ligation.en
dc.typeArticleen
dc.contributor.department1] Department of Pediatrics, Children's Hospital of Los Angeles, University of South California, Los Angeles, CA, USA [2] Department of Pediatrics, University of Oklahoma, Oklahoma, OK, USA.en
dc.identifier.journalJournal of Perinatology : official journal of the California Perinatal Associationen
dc.description.fundingOtheren
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen

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