Assessment of stem cell carriers for tendon tissue engineering in pre-clinical models

Hdl Handle:
http://hdl.handle.net/10147/344531
Title:
Assessment of stem cell carriers for tendon tissue engineering in pre-clinical models
Authors:
Abbah, Sunny A; Spanoudes, Kyriakos; O’Brien, Timothy; Pandit, Abhay; Zeugolis, Dimitrios I
Citation:
Stem Cell Research & Therapy. 2014 Mar 18;5(2):38
Issue Date:
18-Mar-2014
URI:
http://dx.doi.org/10.1186/scrt426; http://hdl.handle.net/10147/344531
Abstract:
Abstract Tendon injuries are prevalent and problematic, especially among young and otherwise healthy individuals. The inherently slow innate healing process combined with the inevitable scar tissue formation compromise functional recovery, imposing the need for the development of therapeutic strategies. The limited number of low activity/reparative capacity tendon-resident cells has directed substantial research efforts towards the exploration of the therapeutic potential of various stem cells in tendon injuries and pathophysiologies. Severe injuries require the use of a stem cell carrier to enable cell localisation at the defect site. The present study describes advancements that injectable carriers, tissue grafts, anisotropically orientated biomaterials, and cell-sheets have achieved in preclinical models as stem cell carriers for tendon repair.
Language:
en
Local subject classification:
PRE CLINICAL MODELS; STEM CELL RESEARCH

Full metadata record

DC FieldValue Language
dc.contributor.authorAbbah, Sunny Aen
dc.contributor.authorSpanoudes, Kyriakosen
dc.contributor.authorO’Brien, Timothyen
dc.contributor.authorPandit, Abhayen
dc.contributor.authorZeugolis, Dimitrios Ien
dc.date.accessioned2015-02-17T12:16:59Zen
dc.date.available2015-02-17T12:16:59Zen
dc.date.issued2014-03-18en
dc.identifier.citationStem Cell Research & Therapy. 2014 Mar 18;5(2):38en
dc.identifier.urihttp://dx.doi.org/10.1186/scrt426en
dc.identifier.urihttp://hdl.handle.net/10147/344531en
dc.description.abstractAbstract Tendon injuries are prevalent and problematic, especially among young and otherwise healthy individuals. The inherently slow innate healing process combined with the inevitable scar tissue formation compromise functional recovery, imposing the need for the development of therapeutic strategies. The limited number of low activity/reparative capacity tendon-resident cells has directed substantial research efforts towards the exploration of the therapeutic potential of various stem cells in tendon injuries and pathophysiologies. Severe injuries require the use of a stem cell carrier to enable cell localisation at the defect site. The present study describes advancements that injectable carriers, tissue grafts, anisotropically orientated biomaterials, and cell-sheets have achieved in preclinical models as stem cell carriers for tendon repair.-
dc.language.isoenen
dc.subject.otherPRE CLINICAL MODELSen
dc.subject.otherSTEM CELL RESEARCHen
dc.titleAssessment of stem cell carriers for tendon tissue engineering in pre-clinical modelsen
dc.language.rfc3066en-
dc.rights.holderSunny Akogwu Abbah et al.; licensee BioMed Central Ltd.-
dc.description.statusPeer Reviewed-
dc.date.updated2015-02-03T08:04:09Z-
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