Clustered multidrug-resistant Bordetella petrii in adult cystic fibrosis patients in Ireland: case report and review of antimicrobial therapies

Hdl Handle:
http://hdl.handle.net/10147/338931
Title:
Clustered multidrug-resistant Bordetella petrii in adult cystic fibrosis patients in Ireland: case report and review of antimicrobial therapies
Authors:
Carleton, Ailise; Casserly, B.; Power, L.; Linnane, B.; O’Flaherty, G.; Powell, J.; Dunne, Colum
Affiliation:
Graduate Entry Medical School and Centre for Interventions in Infection, Inflammation & Immunity (4i), University of Limerick, Limerick, Ireland 2University Hospital Limerick, Dooradoyle, Limerick, Ireland 3Tallaght Hospital, CFAI Reference Laboratory, Dublin, Ireland 4Trinity College Dublin, Clinical Microbiology Department, Dublin, Ireland 5AMRHAI Reference Unit, Reference Microbiology Services, Public Health England, London, United Kingdom
Citation:
Carleton, A., Casserly, B., Power, L., Linnane, B., O’flaherty, G., Powell, J., ... & Dunne, C. (2014). Clustered multidrug‐resistant Bordetella petrii in adult cystic fibrosis patients in Ireland: case report and review of antimicrobial therapies. JMM Case Reports, 1(1), e000075.
Publisher:
The Society for General Microbiology
Journal:
JMM Case Reports
Issue Date:
30-Jan-2014
URI:
http://hdl.handle.net/10147/338931
Abstract:
Introduction: Bordetella petrii is an emerging pathogen. Whilst association with cystic fibrosis (CF) has been described previously, this is the first report to our knowledge of multidrug-resistant B. petrii incidence in an Irish CF patient population. Case presentation: Using a case series of four adult CF patients with varying baselines of health, one of whom was asymptomatic, this report attempts correlation of B. petrii colonization, by one common strain, with incidence of acute exacerbation of symptoms. As definitive guidelines for antimicrobial sensitivity/resistance do not exist for B. petrii, we completed a systematic review of available literature to collate evidence of antimicrobial efficacy against B. petrii. Comparison with the isolates in this study indicated B. petrii sensitivity to piperacillin/ tazobactam and minocycline but resistance to antimicrobials in the macrolide, other b-lactam and fluoroquinolone groups. Conclusion: To our knowledge, this is the first report of multiple CF patients sharing a strain of B. petrii. Furthermore, B. petrii may be under-identified in CF patients and should be considered when evaluating exacerbation of CF symptoms.
Item Type:
Article
Language:
en
Keywords:
CYSTIC FIBROSIS
Local subject classification:
MULTI-DRUG RESISTANCE

Full metadata record

DC FieldValue Language
dc.contributor.authorCarleton, Ailiseen_GB
dc.contributor.authorCasserly, B.en_GB
dc.contributor.authorPower, L.en_GB
dc.contributor.authorLinnane, B.en_GB
dc.contributor.authorO’Flaherty, G.en_GB
dc.contributor.authorPowell, J.en_GB
dc.contributor.authorDunne, Columen_GB
dc.date.accessioned2015-01-27T15:38:24Z-
dc.date.available2015-01-27T15:38:24Z-
dc.date.issued2014-01-30-
dc.identifier.citationCarleton, A., Casserly, B., Power, L., Linnane, B., O’flaherty, G., Powell, J., ... & Dunne, C. (2014). Clustered multidrug‐resistant Bordetella petrii in adult cystic fibrosis patients in Ireland: case report and review of antimicrobial therapies. JMM Case Reports, 1(1), e000075.en_GB
dc.identifier.urihttp://hdl.handle.net/10147/338931-
dc.description.abstractIntroduction: Bordetella petrii is an emerging pathogen. Whilst association with cystic fibrosis (CF) has been described previously, this is the first report to our knowledge of multidrug-resistant B. petrii incidence in an Irish CF patient population. Case presentation: Using a case series of four adult CF patients with varying baselines of health, one of whom was asymptomatic, this report attempts correlation of B. petrii colonization, by one common strain, with incidence of acute exacerbation of symptoms. As definitive guidelines for antimicrobial sensitivity/resistance do not exist for B. petrii, we completed a systematic review of available literature to collate evidence of antimicrobial efficacy against B. petrii. Comparison with the isolates in this study indicated B. petrii sensitivity to piperacillin/ tazobactam and minocycline but resistance to antimicrobials in the macrolide, other b-lactam and fluoroquinolone groups. Conclusion: To our knowledge, this is the first report of multiple CF patients sharing a strain of B. petrii. Furthermore, B. petrii may be under-identified in CF patients and should be considered when evaluating exacerbation of CF symptoms.en_GB
dc.language.isoenen
dc.publisherThe Society for General Microbiologyen_GB
dc.subjectCYSTIC FIBROSISen_GB
dc.subject.otherMULTI-DRUG RESISTANCEen_GB
dc.titleClustered multidrug-resistant Bordetella petrii in adult cystic fibrosis patients in Ireland: case report and review of antimicrobial therapiesen_GB
dc.typeArticleen
dc.contributor.departmentGraduate Entry Medical School and Centre for Interventions in Infection, Inflammation & Immunity (4i), University of Limerick, Limerick, Ireland 2University Hospital Limerick, Dooradoyle, Limerick, Ireland 3Tallaght Hospital, CFAI Reference Laboratory, Dublin, Ireland 4Trinity College Dublin, Clinical Microbiology Department, Dublin, Ireland 5AMRHAI Reference Unit, Reference Microbiology Services, Public Health England, London, United Kingdomen_GB
dc.identifier.journalJMM Case Reportsen_GB
dc.description.fundingNo fundingen
dc.description.provinceMunsteren
dc.description.peer-reviewpeer-reviewen
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