A case of Panton–Valentine leucocidin toxin‐positive Staphylococcus aureus‐mediated neonatal mastitis

Hdl Handle:
http://hdl.handle.net/10147/338914
Title:
A case of Panton–Valentine leucocidin toxin‐positive Staphylococcus aureus‐mediated neonatal mastitis
Authors:
O’Connor, Ciara; O’Connell, Nuala H; Power, Lorraine; Merrigan, Anne; Tormey, Shona; Coffey, Calvin; Linnane, Barry; Dunne, Colum
Affiliation:
1Department of Clinical Microbiology, University Hospital Limerick, Limerick, Ireland 2Centre for Interventions in Infection, Inflammation & Immunity (4i), Graduate‐Entry Medical School, University of Limerick, Limerick, Ireland 3Department of Surgery, University Hospital Limerick, Limerick, Ireland 4Department of Paediatrics, University Hospital Limerick, Limerick, Ireland
Citation:
O’connor, Ciara, et al. "A case of Panton–Valentine leucocidin toxin‐positive Staphylococcus aureus‐mediated neonatal mastitis." JMM Case Reports 1.3 (2014): e004119.
Publisher:
The Society for General Microbiology
Journal:
JMM Case Reports
Issue Date:
1-Sep-2014
URI:
http://hdl.handle.net/10147/338914
Additional Links:
http://jmmcr.sgmjournals.org/content/1/3/e004119.short
Abstract:
Introduction: Neonatal mastitis is an inflammatory condition of the breast frequently associated with Staphylococcus aureus. While Panton–Valentine leucocidin (PVL), a B‐pore‐forming cytotoxin, is commonly associated with enhanced virulence in community‐acquired methicillin‐resistant S. aureus isolates, this is the first report to our knowledge of neonatal mastitis caused by PVL‐positive S. aureus. Case presentation: A 20‐day‐old full‐term female neonate presented with bilateral mastitis, complicated by bilateral abscess formation. PVL toxin‐positive S. aureus was cultured from aspirates of both breasts. All family members, none of whom presented with symptoms of infection, and, specifically, maternal vaginal samples proved negative for PVL‐positive S. aureus. Successful resolution involved surgical drainage and clindamycin therapy. Conclusion: While PVL toxin‐positive S. aureus has previously been implicated in bovine and ovine mastitis, there may now be a need for vigilance with respect to human incidence. Due to PVL‐mediated tissue necrosis, breast abscess formation and poor response to conventional antimicrobial therapy should, perhaps, be a cause for suspicion of PVL‐bearing S. aureus and expediting of appropriate therapy to avoid potential for long‐term consequences such as abnormal breast development.
Item Type:
Article
Language:
en
Keywords:
NEONATE; INFECTION

Full metadata record

DC FieldValue Language
dc.contributor.authorO’Connor, Ciaraen_GB
dc.contributor.authorO’Connell, Nuala Hen_GB
dc.contributor.authorPower, Lorraineen_GB
dc.contributor.authorMerrigan, Anneen_GB
dc.contributor.authorTormey, Shonaen_GB
dc.contributor.authorCoffey, Calvinen_GB
dc.contributor.authorLinnane, Barryen_GB
dc.contributor.authorDunne, Columen_GB
dc.date.accessioned2015-01-27T15:17:50Z-
dc.date.available2015-01-27T15:17:50Z-
dc.date.issued2014-09-01-
dc.identifier.citationO’connor, Ciara, et al. "A case of Panton–Valentine leucocidin toxin‐positive Staphylococcus aureus‐mediated neonatal mastitis." JMM Case Reports 1.3 (2014): e004119.en_GB
dc.identifier.urihttp://hdl.handle.net/10147/338914-
dc.description.abstractIntroduction: Neonatal mastitis is an inflammatory condition of the breast frequently associated with Staphylococcus aureus. While Panton–Valentine leucocidin (PVL), a B‐pore‐forming cytotoxin, is commonly associated with enhanced virulence in community‐acquired methicillin‐resistant S. aureus isolates, this is the first report to our knowledge of neonatal mastitis caused by PVL‐positive S. aureus. Case presentation: A 20‐day‐old full‐term female neonate presented with bilateral mastitis, complicated by bilateral abscess formation. PVL toxin‐positive S. aureus was cultured from aspirates of both breasts. All family members, none of whom presented with symptoms of infection, and, specifically, maternal vaginal samples proved negative for PVL‐positive S. aureus. Successful resolution involved surgical drainage and clindamycin therapy. Conclusion: While PVL toxin‐positive S. aureus has previously been implicated in bovine and ovine mastitis, there may now be a need for vigilance with respect to human incidence. Due to PVL‐mediated tissue necrosis, breast abscess formation and poor response to conventional antimicrobial therapy should, perhaps, be a cause for suspicion of PVL‐bearing S. aureus and expediting of appropriate therapy to avoid potential for long‐term consequences such as abnormal breast development.en_GB
dc.language.isoenen
dc.publisherThe Society for General Microbiologyen_GB
dc.relation.urlhttp://jmmcr.sgmjournals.org/content/1/3/e004119.shorten_GB
dc.subjectNEONATEen_GB
dc.subjectINFECTIONen_GB
dc.titleA case of Panton–Valentine leucocidin toxin‐positive Staphylococcus aureus‐mediated neonatal mastitisen_GB
dc.typeArticleen
dc.contributor.department1Department of Clinical Microbiology, University Hospital Limerick, Limerick, Ireland 2Centre for Interventions in Infection, Inflammation & Immunity (4i), Graduate‐Entry Medical School, University of Limerick, Limerick, Ireland 3Department of Surgery, University Hospital Limerick, Limerick, Ireland 4Department of Paediatrics, University Hospital Limerick, Limerick, Irelanden_GB
dc.identifier.journalJMM Case Reportsen_GB
dc.description.fundingNo fundingen
dc.description.provinceMunsteren
dc.description.peer-reviewpeer-reviewen
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