Prevalence and variation of Chronic Kidney Disease in the Irish health system: initial findings from the National Kidney Disease Surveillance Programme.

Hdl Handle:
http://hdl.handle.net/10147/337125
Title:
Prevalence and variation of Chronic Kidney Disease in the Irish health system: initial findings from the National Kidney Disease Surveillance Programme.
Authors:
Stack, Austin G; Casserly, Liam F; Cronin, Cornelius J; Chernenko, Tetyana; Cullen, Walter; Hannigan, Ailish; Saran, Rajiv; Johnson, Howard; Browne, Gemma; Ferguson, John P
Affiliation:
Departments of Nephrology and Internal Medicine, University Hospital Limerick, Limerick, Ireland. austin.stack@ul.ie.
Citation:
Stack, A.G. et al., 2014. Prevalence and variation of Chronic Kidney Disease in the Irish health system: initial findings from the National Kidney Disease Surveillance Programme. BMC Nephrology. 15:185
Journal:
BMC nephrology
Issue Date:
2014
URI:
http://hdl.handle.net/10147/337125
DOI:
10.1186/1471-2369-15-185
PubMed ID:
25425510
Abstract:
Chronic Kidney Disease (CKD) is a major non-communicable chronic disease that is associated with adverse clinical and economic outcomes. Passive surveillance systems are likely to improve efforts for prevention of chronic kidney disease (CKD) and inform national service planning. This study was conducted to determine the overall prevalence of CKD in the Irish health system, assess period trends and explore patterns of variation as part of a novel surveillance initiative.; We identified 207, 336 adult patients, age 18 and over, with serum creatinine measurements recorded from a provincial database between 2005-2011 in the Northwest of Ireland. Estimated glomerular filtration rates (eGFR) were determined using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation from standardized creatinine measurements and the presence of CKD was defined as eGFR <60 ml/min per 1.73 m2. Age and sex-specific prevalence estimates were determined for each group while generalized estimating equations (GEE) and multivariable logistic regression were used to explore associations using adjusted odds ratios (AOR) and 95% confidence intervals (95% CI).; The prevalence of CKD in the health system was 11.8% (95% CI 11.8-12.1); 10.9% in men (10.7-11.1) and 12.6% in women (12.4-12.8). This corresponded to a detection rate of 4.5% (5.1% in women and 3.9% in men). The prevalence of CKD was significantly higher in women than in men (12.6% versus 10.9%, P < 0.001), older age groups, and among patients with a history of Acute Kidney Injury (AKI) than without (45.2% versus 10.7%, P < 0.0001). Multivariable analysis identified advancing age, female gender, location of medical supervision, county of residence, and AKI as significant determinants of prevalence.; The prevalence of CKD in the Irish health system is 11.8% corresponding to a detection rate of 4.5% in the general population. Demographic, geographic factors and acute kidney injury episodes are important determinants of disease burden. Passive surveillance of CKD is both feasible and desirable within the Irish health system, and offers huge opportunities for targeted prevention programmes and improved clinical outcomes.
Item Type:
Article
Language:
en
Keywords:
KIDNEY DISEASE; HEALTH SERVICES
ISSN:
1471-2369

Full metadata record

DC FieldValue Language
dc.contributor.authorStack, Austin Gen_GB
dc.contributor.authorCasserly, Liam Fen_GB
dc.contributor.authorCronin, Cornelius Jen_GB
dc.contributor.authorChernenko, Tetyanaen_GB
dc.contributor.authorCullen, Walteren_GB
dc.contributor.authorHannigan, Ailishen_GB
dc.contributor.authorSaran, Rajiven_GB
dc.contributor.authorJohnson, Howarden_GB
dc.contributor.authorBrowne, Gemmaen_GB
dc.contributor.authorFerguson, John Pen_GB
dc.date.accessioned2014-12-12T16:04:29Z-
dc.date.available2014-12-12T16:04:29Z-
dc.date.issued2014-
dc.identifier.citationStack, A.G. et al., 2014. Prevalence and variation of Chronic Kidney Disease in the Irish health system: initial findings from the National Kidney Disease Surveillance Programme. BMC Nephrology. 15:185en_GB
dc.identifier.issn1471-2369-
dc.identifier.pmid25425510-
dc.identifier.doi10.1186/1471-2369-15-185-
dc.identifier.urihttp://hdl.handle.net/10147/337125-
dc.description.abstractChronic Kidney Disease (CKD) is a major non-communicable chronic disease that is associated with adverse clinical and economic outcomes. Passive surveillance systems are likely to improve efforts for prevention of chronic kidney disease (CKD) and inform national service planning. This study was conducted to determine the overall prevalence of CKD in the Irish health system, assess period trends and explore patterns of variation as part of a novel surveillance initiative.-
dc.description.abstractWe identified 207, 336 adult patients, age 18 and over, with serum creatinine measurements recorded from a provincial database between 2005-2011 in the Northwest of Ireland. Estimated glomerular filtration rates (eGFR) were determined using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation from standardized creatinine measurements and the presence of CKD was defined as eGFR <60 ml/min per 1.73 m2. Age and sex-specific prevalence estimates were determined for each group while generalized estimating equations (GEE) and multivariable logistic regression were used to explore associations using adjusted odds ratios (AOR) and 95% confidence intervals (95% CI).-
dc.description.abstractThe prevalence of CKD in the health system was 11.8% (95% CI 11.8-12.1); 10.9% in men (10.7-11.1) and 12.6% in women (12.4-12.8). This corresponded to a detection rate of 4.5% (5.1% in women and 3.9% in men). The prevalence of CKD was significantly higher in women than in men (12.6% versus 10.9%, P < 0.001), older age groups, and among patients with a history of Acute Kidney Injury (AKI) than without (45.2% versus 10.7%, P < 0.0001). Multivariable analysis identified advancing age, female gender, location of medical supervision, county of residence, and AKI as significant determinants of prevalence.-
dc.description.abstractThe prevalence of CKD in the Irish health system is 11.8% corresponding to a detection rate of 4.5% in the general population. Demographic, geographic factors and acute kidney injury episodes are important determinants of disease burden. Passive surveillance of CKD is both feasible and desirable within the Irish health system, and offers huge opportunities for targeted prevention programmes and improved clinical outcomes.-
dc.language.isoenen
dc.rightsArchived with thanks to BMC nephrologyen_GB
dc.subjectKIDNEY DISEASEen_GB
dc.subjectHEALTH SERVICESen_GB
dc.titlePrevalence and variation of Chronic Kidney Disease in the Irish health system: initial findings from the National Kidney Disease Surveillance Programme.en_GB
dc.typeArticleen
dc.contributor.departmentDepartments of Nephrology and Internal Medicine, University Hospital Limerick, Limerick, Ireland. austin.stack@ul.ie.en_GB
dc.identifier.journalBMC nephrologyen_GB

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